The Role of Gastric Sensorineural Dysfunction in Functional Dyspepsia

2014 ◽  
pp. 38-44
Author(s):  
Jan Tack
Keyword(s):  
Functional Dyspepsia

scholarly journals Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

2021 ◽  
Vol 22 (24) ◽  
pp. 13609
Author(s):  
Lucas Wauters ◽  
Raúl Y. Tito ◽  
Matthias Ceulemans ◽  
Maarten Lambaerts ◽  
Alison Accarie ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Role ◽  
Short Term ◽  
Beneficial Effects ◽  
Rrna Sequencing ◽  
Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

scholarly journals The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

2020 ◽  
Vol 11 ◽  
Author(s):  
Karen Van den Houte ◽  
Emidio Scarpellini ◽  
Wout Verbeure ◽  
Hideki Mori ◽  
Jolien Schol ◽  
...  
Keyword(s):  
Systematic Review ◽  
Functional Dyspepsia

The Role of Duodenal Inflammation in Functional Dyspepsia

2017 ◽  
Vol 51 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Marjorie M. Walker ◽  
Nicholas J. Talley
Keyword(s):  
Functional Dyspepsia

scholarly journals Role of Ultrasonoraphy in Gall bladder Dyskinsia as a cause of Functional Dyspepsia Symptoms

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ayman Abdelmofeed ◽  
Mohamed Awaad ◽  
Fatma Atef
Keyword(s):  
Gall Bladder ◽  
Functional Dyspepsia
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