Evaluation of Superficial Oral Squamous Cell Malignancy Based on Morphometry and Immunoexpression of Cytokeratin 13 and Cytokeratin 17

2014 ◽  
Vol 58 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Mitsumasa Yamashina ◽  
Kazumichi Sato ◽  
Morio Tonogi ◽  
Yoichi Tanaka ◽  
Gen-yuki Yamane ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Cytokeratin 17 ◽  
Cytokeratin 13 ◽  
Cell Malignancy

Diagnostic utility of Cytokeratin 13 and Cytokeratin 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

2020 ◽  
Vol 5 (4) ◽  
pp. 153-158
Author(s):  
Maryam Nazir Kiani ◽  
Muhammad Asif ◽  
Fakeha Meraj Ansari ◽  
Nighat Ara ◽  
Muhammad Ishaque ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Dysplasia ◽  
P Value ◽  
Oral Epithelial Dysplasia ◽  
Cytokeratin 17 ◽  
Cytokeratin 13 ◽  
Oral Epithelial

Objective: To determine the immunohistochemical expression of CK 13 and CK 17 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Methods: A total of 170 cases were retrieved from record files of Histopathology Department, to conduct a cross sectional study at Armed Forces Institute of Pathology, Rawalpindi, over a period of one year from June 2018 to June 2019 along with their formalin-fixed, paraffin embedded blocks comprising 85 cases of each oral squamous cell carcinoma and oral epithelial dysplasia. Blocks were trimmed and cut into very thin sections of 5 microns using microtome and mounted on slides. Tissue mounted slides were stained with routine haematoxylin and eosin followed by immunohistochemical staining of cytokeratin 13 and cytokeratin 17. New histological diagnosis of each case was made. Mean and standard deviation were calculated for quantitative variables. Frequency and percentages were calculated for qualitative variables. Chi-square test was employed to assess the significance of difference. The P-value <0.05 was considered significant. Results: In this study, 101 (59.4%) male and 69 (40.6%) female patients with the mean age of 60.63 ± 13.814 (mean ± SD) were collected and buccal mucosa was the most common site of presentation. In a total of 170 cases, 34 (20%) cases showed positive expression of cytokeratin 13 whereas 136 (80%) cases showed negative expression of cytokeratin 13. In comparison, out of 170 cases, 133 (78.2%) cases showed positive expression of cytokeratin 17 whereas 37 (21.8%) cases showed negative expression of cytokeratin 17. The P-value was found to be < 0.001 and 0.001 for expression of cytokeratin 13 and cytokeratin 17 respectively. Conclusion: Opposite expression of cytokeratin 13 and cytokeratin 17 was seen in this study, in the form of loss of cytokeratin 13 and over expression of cytokeratin 17 with increase in the degree of dysplasia and invasive carcinoma. Correct assessment, diagnosis and management with the help of these markers can lead to early diagnosis and favorable treatment outcome.

Proteomic profiles and cytokeratin 13 as a potential biomarker of Ovis aries papillomavirus 3-positive and negative cutaneous squamous cell carcinomas

2021 ◽  
Vol 134 ◽  
pp. 112-119
Author(s):  
Veronica Vitiello ◽  
Giovanni P. Burrai ◽  
Salvatore Pisanu ◽  
Carla Cacciotto ◽  
Maria Filippa Addis ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Ovis Aries ◽  
Potential Biomarker ◽  
Cytokeratin 13

scholarly journals Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma

2012 ◽  
Vol 138 (8) ◽  
pp. 1299-1310 ◽  
Author(s):  
Ryoji Kitamura ◽  
Takeshi Toyoshima ◽  
Hideaki Tanaka ◽  
Shintaro Kawano ◽  
Takahiro Kiyosue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cytokeratin 17

scholarly journals Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma

2017 ◽  
Vol 13 (4) ◽  
pp. 2539-2548
Author(s):  
Cem Leblebici ◽  
Esra Pasaoglu ◽  
Canan Kelten ◽  
Seher Darakci ◽  
Nevra Dursun
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ki 67 ◽  
Cytokeratin 17 ◽  
Immunohistochemical Markers

scholarly journals Rare Case of Duodenal Metastasis From Pulmonary Squamous Cell Carcinoma

2017 ◽  
Vol 5 (4) ◽  
pp. 232470961773756 ◽  
Author(s):  
Zain Memon ◽  
Samson Ferm ◽  
Constantine Fisher ◽  
Akil Hassam ◽  
Jean Luo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Case ◽  
Adrenal Glands ◽  
Stage Iv ◽  
Small Cell ◽  
Uncommon Presentation ◽  
Primary Lung Tumors ◽  
Cell Malignancy

Pulmonary squamous cell carcinoma is the second most common non–small cell malignancy of the lung. It commonly metastasizes to the adrenal glands, bone, liver, brain, and kidneys. Most occurrences of metastatic squamous cell carcinoma involving the gastrointestinal tract originate from primary lung tumors. Metastasis to the duodenum, however, is exceedingly rare, with very few cases of stomach or duodenal involvement described in the literature. We report the case of a patient with stage IV pulmonary squamous cell carcinoma metastasizing to the duodenum with an uncommon presentation to add to the paucity of literature available regarding this rare finding.

scholarly journals The Evaluation of Serum Il-6 Changes as Proliferative Cytokines in Patients With Nasopharyngeal Carcinoma Before and After the Ionizing Radiotherapy

2018 ◽  
Vol 10 (8) ◽  
pp. 55
Author(s):  
Abdul Kadir ◽  
Kurnia Retnowati ◽  
M. Amsyar Akil ◽  
Andi Usman
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Squamous Cell ◽  
Prospective Cohort ◽  
Stage I ◽  
Stage Ii ◽  
Epithelial Layer ◽  
Research Results ◽  
Radio Therapy ◽  
Before And After ◽  
Cell Malignancy

BACKGROUND: Nasopharyngeal carcinoma is a squamous cell malignancy derived from the nasopharyngeal epithelial layer. This study aimed to calculate the IL-6 levels in patients with nasopharyngeal carcinoma before and after radiotherapy, in the week I and week 3 during the radiotherapy, and 2 weeks after the radiotherapy.METHODS: The study was conducted in a prospective cohort on 16 people suffering from nasopharyngeal carcinoma and undergoing radiotherapy, i.e. 9 patients were in stage I of nasopharyngeal carcinoma and 7 people were in stage II of nasopharyngeal carcinoma. Each sample underwent the examination of IL-6 before the week I and week 3 during the radiotherapy, and 2 weeks after the radio¬therapy.RESULTS: The more they received the treatment with radiotherapy the greater was the decrease of serum IL-6. The percentages of the decrease of the levels of serum IL-6 was greater in those receiving the 3-week duration of radiotherapy (24.59%) compared to those who just received 1-week duration of radiotherapy (6.44%). The decrease of serum IL-6 would continue, although radio-therapy had ended; 2 weeks after the radio-therapy, the percentage of serum IL-6 decreased to 42.43% from the level of serum IL-6 before the radio-therapy.CONCLUSIONS: The research results indicated that there happened a significant decrease of serum IL-6 (p&lt;0.05) after the treatment with the radio-therapy

scholarly journals Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma

2017 ◽  
Author(s):  
Ryoji Kitamura ◽  
Takeshi Toyoshima ◽  
Hideaki Tanaka ◽  
Shintaro Kawano ◽  
Ryota Matsubara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prognostic Marker ◽  
Squamous Cell ◽  
Cytokeratin 17

Cytokeratin 17 mRNA expression has potential for diagnostic marker of oral squamous cell carcinoma

2007 ◽  
Vol 134 (4) ◽  
pp. 515-521 ◽  
Author(s):  
Takeshi Toyoshima ◽  
Eleftherios Vairaktaris ◽  
Emeka Nkenke ◽  
Karl Andreas Schlegel ◽  
Friedrich Wilhelm Neukam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Diagnostic Marker ◽  
Cytokeratin 17
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