scholarly journals Effectiveness of a Low-Calorie Weight Loss Program in Moderately and Severely Obese Patients

Obesity Facts ◽  
2013 ◽  
Vol 6 (5) ◽  
pp. 469-480 ◽  
Author(s):  
Julia K. Winkler ◽  
Jobst-Hendrik Schultz ◽  
Annika Woehning ◽  
David Piel ◽  
Lena Gartner ◽  
...  
Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4468
Author(s):  
Ivan Ožvald ◽  
Dragan Božičević ◽  
Lidija Duh ◽  
Ivana Vinković Vrček ◽  
Ivan Pavičić ◽  
...  

Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized weight loss program developed at the Duga Resa Special Hospital for Extended Treatment, Croatia, we evaluated anthropometric, biochemical, and permanent DNA damage parameters (assessed with the cytochalasin B-blocked micronucleus cytome assay—CBMN) in severely obese patients (BMI ≥ 35 kg m−2) after 3-weeks on a 567 kcal, hospital-controlled VLCD. This is the first study on the permanent genomic (in)stability in such VLCD patients. VLCDs caused significant decreases in weight (loss), parameters of the lipid profile, urea, insulin resistance, and reduced glutathione (GSH). Genomic instability parameters were lowered by half, reaching reference values usually found in the healthy population. A correlation was found between GSH decrease and reduced DNA damage. VLCDs revealed susceptible individuals with remaining higher DNA damage for further monitoring. In a highly heterogeneous group (class II and III in obesity, differences in weight, BMI, and other categories) consisting of 26 obese patients, the approach demonstrated its usefulness and benefits in health improvement, enabling an individual approach to further monitoring, diagnosis, treatment, and risk assessment based on changing anthropometric/biochemical VLCD parameters, and CBMN results.


2005 ◽  
Vol 90 (5) ◽  
pp. 2653-2658 ◽  
Author(s):  
Angelika Mohn ◽  
Mariangela Catino ◽  
Rita Capanna ◽  
Cosimo Giannini ◽  
Maria Marcovecchio ◽  
...  

2011 ◽  
Vol 35 (2) ◽  
pp. 188
Author(s):  
A. Auclair ◽  
J. Martin ◽  
M. Bastien ◽  
N. Bonneville ◽  
S. Marceau ◽  
...  

Author(s):  
Phillip J. Brantley ◽  
Win Guan ◽  
Ricky Brock ◽  
Dachuan Zhang ◽  
Gang Hu

This paper describes the methodology, design and procedures used in the HEADS UP Project, an observational study to examine the feasibility of a state-funded weight loss program. HEADS UP offered two weight loss approaches: bariatric surgery or a non-surgical intervention composed of medical management, a low-calorie liquid diet and lifestyle change promotion. Participants were recruited through a multi-stage screening process, in-person interviews, and an initial low-calorie diet program. Eligible participants were entered into a lottery system, with 100 participants selected for the surgical group and 200 selected for the non-surgical group annually for five years. Anthropometric, clinical, and psychosocial assessments were completed at baseline and follow-ups. More than 6800 individuals completed the initial web screening. Screening procedures yielded 1412 participants (490 surgical and 922 non-surgical). Approximately 84% of the total participant population were female and 38% were Black. Participants had an average body mass index of 47.9 and 43 kg/m2 in the surgical and non-surgical groups, respectively. Recruitment and enrollment results of the HEADS UP study demonstrated significant interest in both the surgical and non-surgical treatment programs for obesity. These results support the feasibility of providing a state-funded weight loss program within a healthcare setting.


Obesity ◽  
2012 ◽  
Vol 20 (5) ◽  
pp. 1048-1056 ◽  
Author(s):  
Eva Pardina ◽  
Roser Ferrer ◽  
Joaquín Rivero ◽  
Juan A. Baena-Fustegueras ◽  
Albert Lecube ◽  
...  

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