The EFEMP1 Gene: A Frequent Target for Epigenetic Silencing in Multiple Human Pituitary Adenoma Subtypes

2013 ◽  
Vol 98 (3) ◽  
pp. 200-211 ◽  
Author(s):  
Cuong V. Duong ◽  
Kiren Yacqub-Usman ◽  
Richard D. Emes ◽  
Richard N. Clayton ◽  
William E. Farrell
Keyword(s):  
Pituitary Adenoma ◽  
Epigenetic Silencing ◽  
Human Pituitary ◽  
Human Pituitary Adenoma

Isolation of large numbers of dispersed human pituitary adenoma cells obtained by aspiration

1984 ◽  
Vol 7 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Robert Oosterom ◽  
G. Blaauw ◽  
R. Singh ◽  
T. Verleun ◽  
S. W. J. Lamberts
Keyword(s):  
Pituitary Adenoma ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Large Numbers

scholarly journals miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase Cδ

Endocrinology ◽  
2013 ◽  
Vol 154 (5) ◽  
pp. 1690-1700 ◽  
Author(s):  
Erica Gentilin ◽  
Federico Tagliati ◽  
Carlo Filieri ◽  
Daniela Molè ◽  
Mariella Minoia ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pituitary Adenoma ◽  
Protein Kinase ◽  
Pituitary Adenomas ◽  
Viable Cell Number ◽  
Pituitary Cells ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Acth Secreting ◽  
Protein Kinase Cδ

Abstract The functional aftermath of microRNA (miRNA) dysregulation in ACTH-secreting pituitary adenomas has not been demonstrated. miRNAs represent diagnostic and prognostic biomarkers as well as putative therapeutic targets; their investigation may shed light on the mechanisms that underpin pituitary adenoma development and progression. Drugs interacting with such pathways may help in achieving disease control also in the settings of ACTH-secreting pituitary adenomas. We investigated the expression of 10 miRNAs among those that were found as most dysregulated in human pituitary adenoma tissues in the settings of a murine ACTH-secreting pituitary adenoma cell line, AtT20/D16v-F2. The selected miRNAs to be submitted to further investigation in AtT20/D16v-F2 cells represent an expression panel including 5 up-regulated and 5 down-regulated miRNAs. Among these, we selected the most dysregulated mouse miRNA and searched for miRNA targets and their biological function. We found that AtT20/D16v-F2 cells have a specific miRNA expression profile and that miR-26a is the most dysregulated miRNA. The latter is overexpressed in human pituitary adenomas and can control viable cell number in the in vitro model without involving caspase 3/7-mediated apoptosis. We demonstrated that protein kinase Cδ (PRKCD) is a direct target of miR-26a and that miR26a inhibition delays the cell cycle in G1 phase. This effect involves down-regulation of cyclin E and cyclin A expression via PRKCD modulation. miR-26a and related pathways, such as PRKCD, play an important role in cell cycle control of ACTH pituitary cells, opening new therapeutic possibilities for the treatment of persistent/recurrent Cushing's disease.

Localization of concanavalin A binding sites in human pituitary adenoma cells as revealed by HRP-labelling method

1983 ◽  
Vol 62 (1-2) ◽  
pp. 59-66 ◽  
Author(s):  
T. Hori ◽  
F. Nishiyama ◽  
A. Teramoto ◽  
M. Matsutani ◽  
K. Takakura ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Concanavalin A ◽  
Binding Sites ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Labelling Method

Expression of neuropeptide Y in human pituitary adenoma

2006 ◽  
Vol 3 (1) ◽  
pp. 25-31
Author(s):  
Laizhao Chen ◽  
Jingjian Ma ◽  
Anchao Zheng ◽  
Honggang Zheng
Keyword(s):  
Pituitary Adenoma ◽  
Neuropeptide Y ◽  
Human Pituitary ◽  
Human Pituitary Adenoma

scholarly journals Stimulation by Urocortin of Growth Hormone (GH) Secretion in GH-Producing Human Pituitary Adenoma Cells.

1997 ◽  
Vol 44 (4) ◽  
pp. 627-629 ◽  
Author(s):  
YOSHIO MURAKAMI ◽  
TOSHIAKI MORI ◽  
KUNIO KOSHIMURA ◽  
MASAMICHI KUROSAKI ◽  
TOMOKATSU HORI ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Gh Secretion

scholarly journals siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770480 ◽  
Author(s):  
Kai Zhou ◽  
Yan-Dong Fan ◽  
Serick Duysenbi ◽  
Peng-Fei Wu ◽  
Zhao-Hai Feng ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Migration And Invasion ◽  
Human Pituitary ◽  
Human Pituitary Adenoma

A human pituitary adenoma cell line proliferates and maintains some differentiated functions following expression of SV40 large T-antigen

1998 ◽  
Vol 9 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Long Jin ◽  
Elzbieta Kulig ◽  
Xiang Qian ◽  
Bernd W. Scheithauer ◽  
Norman L. Eberhardt ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Line ◽  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell
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