High Rate of Symptomatic Cytomegalovirus Infection in Extremely Low Gestational Age Preterm Infants of 22-24 Weeks' Gestation after Transmission via Breast Milk

Neonatology ◽  
2014 ◽  
Vol 105 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Katrin Mehler ◽  
André Oberthuer ◽  
Ruth Lang-Roth ◽  
Angela Kribs
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Gestational Age ◽  
Cytomegalovirus Infection ◽  
High Rate ◽  
Extremely Low Gestational Age

Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infants

2004 ◽  
Vol 23 (4) ◽  
pp. 322-327 ◽  
Author(s):  
BRIGITTE VOLLMER ◽  
KARIN SEIBOLD-WEIGER ◽  
CHRISTINE SCHMITZ-SALUE ◽  
KLAUS HAMPRECHT ◽  
RANGMAR GOELZ ◽  
...  
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Cytomegalovirus Infection

Outcome of extremely low gestational age newborns after introduction of a revised protocol to assist preterm infants in their transition to extrauterine life

2012 ◽  
Vol 101 (12) ◽  
pp. 1232-1239 ◽  
Author(s):  
Katrin Mehler ◽  
Judith Grimme ◽  
Julia Abele ◽  
Christoph Huenseler ◽  
Bernhard Roth ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Extremely Low Gestational Age

scholarly journals High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Jonas Teng ◽  
Anne Elwin ◽  
Soley Omarsdottir ◽  
Giulia Aquilano ◽  
Mireille Vanpee ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Gestational Age ◽  
Blood Cells ◽  
Simultaneous Detection ◽  
High Rate ◽  
Control Group ◽  
Cmv Infection ◽  
Multivariable Logistic Regression Model ◽  
Taqman Pcr

Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis.Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age.Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044).Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality.

scholarly journals Nutritional practices and growth of preterm infants in two neonatal units in the UK and Malaysia: a prospective exploratory study

2021 ◽  
Vol 5 (1) ◽  
pp. e001153
Author(s):  
Haslina Abdul Hamid ◽  
Lisa Szatkowski ◽  
Helen Budge ◽  
Fook-Choe Cheah ◽  
Shalini Ojha
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Gestational Age ◽  
Exploratory Study ◽  
Patient Characteristics ◽  
Maternal Characteristics ◽  
Growth Outcomes ◽  
The Uk ◽  
Larger Sample ◽  
Weight For Age

ObjectiveTo explore differences in nutritional practices and growth outcomes among preterm infants in neonatal units in Malaysia and the UK.DesignProspective exploratory study of infants born at <34 weeks gestational age (GA).SettingTwo neonatal units, one in Malaysia and one in the UK (May 2019 to March 2020).MethodsData collected from birth until discharge and compared between units.ResultsFrom 100 infants included, median GA (IQR) was 31 (30–33) and mean±SD birth weight was 1549±444 g. There were more small-for-gestational age infants in Malaysian unit: 12/50 (24%) vs UK: 3/50 (6%), p=0.012 and more morbidities. More Malaysian infants received breast milk (Malaysia: 49 (98%) vs UK: 38 (76%), p=0.001), fortified breast milk (Malaysia: 43 (86%) vs UK: 13 (26%), p<0.001) and exclusive breast milk at discharge (Malaysia: 26 (52%) vs UK: 16 (32%), p=0.043). There was higher parenteral nutrition use among Malaysian infants (40/50 (80%)) vs UK (19/50 (38%)) (p<0.001) with higher protein intake (mean±SD Malaysia: 3.0±0.5 vs UK: 2.7±0.6 g/kg/d, p=0.004) in weeks 1–4 and smaller cumulative protein deficits (mean±SD Malaysia: 11.4±6.1 vs UK: 15.4±8.0 g/kg, p=0.006). There were no significant differences in short-term growth between units and more than half of the infants in both units had ≥1.28 changes in weight-for-age Z-score at discharge (p=0.841).ConclusionsAn exploratory comparison of practices showed differences in patient characteristics and nutritional practices which impacted growth. Future studies with larger sample sizes and detailed analysis of maternal characteristics and infants’ outcomes are needed for improving care of preterm infants in all settings.

scholarly journals Breast Milk-Transmitted Cytomegalovirus Infection in Preterm Infants

2018 ◽  
Vol 25 (2) ◽  
pp. 58-65
Author(s):  
Mi Hyeon Gang ◽  
Mea-young Chang
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Cytomegalovirus Infection

Breast milk and cytomegalovirus infection in preterm infants

2005 ◽  
Vol 81 (12) ◽  
pp. 989-996 ◽  
Author(s):  
Klaus Hamprecht ◽  
Rangmar Goelz ◽  
Jens Maschmann
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Cytomegalovirus Infection
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