Coinfection ofPneumocystis jiroveciiand Invasive Pulmonary Aspergillosis in an Immunocompromised Patient: A Diagnostic Challenge

Onkologie ◽  
2013 ◽  
Vol 36 (10) ◽  
pp. 582-584 ◽  
Author(s):  
Stefan Baumann ◽  
Mark Reinwald ◽  
Dariush Haghi ◽  
Wolf-Karsten Hofmann ◽  
Dieter Buchheidt
Keyword(s):  
Immunocompromised Patient ◽  
Invasive Pulmonary Aspergillosis ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis

INVASIVE PULMONARY ASPERGILLOSIS IN AN IMMUNOCOMPROMISED PATIENT: A CASE REPORT

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 116A
Author(s):  
SUJAN JAMARKATTEL ◽  
RAVI MANGLANI ◽  
GREGORY HOGE ◽  
KAMAL ALBRIGHT
Keyword(s):  
Case Report ◽  
Immunocompromised Patient ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis

scholarly journals Invasive pulmonary aspergillosis complicating SARS-CoV-2 pneumonia: A diagnostic challenge

2020 ◽  
Vol 38 ◽  
pp. 101752 ◽  
Author(s):  
Spinello Antinori ◽  
Roberto Rech ◽  
Laura Galimberti ◽  
Antonio Castelli ◽  
Elena Angeli ◽  
...  
Keyword(s):  
Invasive Pulmonary Aspergillosis ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis

Thoracoscopic Lingulectomy for Invasive Pulmonary Aspergillosis

2007 ◽  
Vol 73 (3) ◽  
pp. 279-280 ◽  
Author(s):  
Bryan A. Whitson ◽  
Michael A. Maddaus ◽  
Rafael S. Andrade
Keyword(s):  
Acute Myeloid Leukemia ◽  
Mortality Rate ◽  
Myeloid Leukemia ◽  
Immunocompromised Patient ◽  
Lung Resection ◽  
Invasive Pulmonary Aspergillosis ◽  
Immunocompromised Patients ◽  
Anatomic Resection ◽  
Pulmonary Aspergillosis ◽  
Acute Myeloid

Invasive pulmonary aspergillosis (IPA) is associated with a high mortality rate in immunocompromised patients. Surgery has a therapeutic role for selected patients when the main objective is to achieve infection control with minimal lung resection. Large or deep-seated lesions may require an anatomic resection such as segmentectomy, lobectomy, or pneumonectomy. Thoracoscopic lobectomy has been described as a treatment of localized IPA; however, thoracoscopic anatomic segmentectomy has not been reported until now. Herein, we describe a case of thoracoscopic lingulectomy for localized IPA in an immunocompromised patient: this operation minimized the delay in resuming therapy for the patient's underlying acute myeloid leukemia. Video-assisted thoracoscopic segmentectomy can be safely performed for localized IPA.

scholarly journals Case Report: Diagnostic challenge of COVID-19 associated pulmonary aspergillosis (CAPA)

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 58
Author(s):  
Hanan Albasata ◽  
Maha M. Alamri ◽  
Saud A. Almuhaidb ◽  
Abdullah M. Aljebreen ◽  
Reem S. Almaghrabia
Keyword(s):  
Mechanical Ventilation ◽  
Fungal Infection ◽  
Fungal Infections ◽  
Early Recognition ◽  
Invasive Pulmonary Aspergillosis ◽  
Antimicrobial Treatment ◽  
World Health ◽  
Main Diagnosis ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis

Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). Severe COVID-19 is represented with acute respiratory distress syndrome (ARDS) that requires mechanical ventilation. Moreover, recent studies are reporting invasive fungal infection associated with severe COVID-19. It is unclear whether the prescription of immunotherapies such as corticosteroids, or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection itself is risk factor for COVID-19-associated invasive pulmonary aspergillosis (CAPA). Hence, fungal infections present an additional uncertainty in managing COVID-19 patients and further compromise the outcome. Case study: Here we report a case of SARS-CoV-2 complicated by invasive pulmonary aspergillosis (IPA) in a patient with no traditional risk factors for IPA. Admitted to ICU due to ARDS on mechanical ventilation, the patient deteriorated clinically with unexplained increased of fraction of inspired oxygen (FiO2) requirement from 50% to 80%. Investigations showed borderline serum galactomannan, nonspecific radiological findings reported to be atypical for COVID-19, and the respiratory sample grew Aspergillus spp. Main diagnosis: COVID-19 related fungal infection. The patient was treated with antifungal therapy for four weeks. He improved clinically after one week of starting antimicrobial treatment. After a prolonged ICU stay (87 days) due to infection control precaution, he was discharged from the ICU and moved to a long-term facility for further management and support. Conclusions: This case highlights the diagnostic challenge in such cases. and the importance of early recognition of CAPA which can optimize therapy by administration of appropriate antifungal agents that may impact mortality.

scholarly journals Case Report: Diagnostic challenge of COVID-19 associated pulmonary aspergillosis (CAPA)

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 58
Author(s):  
Hanan Albasata ◽  
Maha M. Alamri ◽  
Saud A. Almuhaidb ◽  
Abdullah M. Aljebreen ◽  
Reem S. Almaghrabia
Keyword(s):  
Mechanical Ventilation ◽  
Fungal Infection ◽  
Fungal Infections ◽  
Early Recognition ◽  
Invasive Pulmonary Aspergillosis ◽  
Antimicrobial Treatment ◽  
World Health ◽  
Main Diagnosis ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis

Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). Severe COVID-19 is represented with acute respiratory distress syndrome (ARDS) that requires mechanical ventilation. Moreover, recent studies are reporting invasive fungal infection associated with severe COVID-19. It is unclear whether the prescription of immunotherapies such as corticosteroids, or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection itself is risk factor for COVID-19-associated invasive pulmonary aspergillosis (CAPA). Hence, fungal infections present an additional uncertainty in managing COVID-19 patients and further compromise the outcome. Case study: Here we report a case of SARS-CoV-2 complicated by invasive pulmonary aspergillosis (IPA) in a patient with no traditional risk factors for IPA. Admitted to ICU due to ARDS on mechanical ventilation, the patient deteriorated clinically with unexplained increased of fraction of inspired oxygen (FiO2) requirement from 50% to 80%. Investigations showed borderline serum galactomannan, nonspecific radiological findings reported to be atypical for COVID-19, and the respiratory sample grew Aspergillus spp. Main diagnosis: COVID-19 related fungal infection. The patient was treated with antifungal therapy for four weeks. He improved clinically after one week of starting antimicrobial treatment. After a prolonged ICU stay (87 days) due to infection control precaution, he was discharged from the ICU and moved to a long-term facility for further management and support. Conclusions: This case highlights the diagnostic challenge in such cases. and the importance of early recognition of CAPA which can optimize therapy by administration of appropriate antifungal agents that may impact mortality.

scholarly journals Assessment of serum Aspergillus galactomannan expression and associated risk factors among patients living with HIV at Ilorin, Nigeria

2019 ◽  
Vol 34 (2) ◽  
Author(s):  
Hafeez Aderinsayo Adekola ◽  
Olajide Olubunmi Agbede ◽  
Idris Nasir Abdullahi ◽  
Lawal O. Olayemi ◽  
Anthony Uchenna Emeribe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Optical Density ◽  
Progressive Failure ◽  
Invasive Pulmonary Aspergillosis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis ◽  
Associated Risk Factors ◽  
Living With Hiv ◽  
Hiv Aids

Invasive pulmonary aspergillosis still constitutes a diagnostic challenge for clinicians due to its non-specific symptoms. HIV infection represents one of the major risk factors due to the progressive failure of the immune system. In this study, Aspergillus serum galactomannan enzyme linked immunosorbent assay was used for the diagnosis of invasive pulmonary aspergillosis in patients living with HIV/AIDS attending University of Ilorin Teaching Hospital Antiretroviral Therapy Clinic, Nigeria. Blood samples were collected from 97 patients affected by HIV/AIDS. Age range of the study population was between 0 and 79 years. Length of the study: 3 weeks. Three out of the 97 samples were positive for the galactomannan assay with an optical density index of 1.1, 0.9 and 1.1 using the 0.5 cut-off optical density value; the concentration level of galactomannan antigen was therefore 2.20 μg/L, 1 μg/L and 2.19 μg/L, respectively. A prevalence of 3.1 % (3/97) was detected; all positive participants have been on ART for more than 3 years (P<0.0001), and 2 out of the 3 had CD4 count higher than 200 cells/mm3 (P<0.0001). Serum Aspergillus galactomannan assay is less invasive for patients and diagnosis can be made in a relatively shorter time compared to other techniques used in diagnosing invasive pulmonary aspergillosis.

scholarly journals Invasive pulmonary aspergillosis in an ICU patient with Legionnaires’ disease: A diagnostic challenge

2020 ◽  
Vol 30 (3) ◽  
pp. 100985 ◽  
Author(s):  
P. Coulon ◽  
C. Cordier ◽  
P. Saint-Léger ◽  
F. Lambiotte ◽  
S. Loridant ◽  
...  
Keyword(s):  
Invasive Pulmonary Aspergillosis ◽  
Diagnostic Challenge ◽  
Pulmonary Aspergillosis ◽  
Legionnaires Disease

Translational immunoPET/MR imaging of invasive pulmonary aspergillosis

2019 ◽  
Author(s):  
J Schwenck ◽  
N Beziere ◽  
A Maurer ◽  
AM Wild ◽  
H Henneberg ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis
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