Prognostic Factors for Recurrence-Free Survival in Patients with HER2-Positive Early-Stage Breast Cancer Treated with Adjuvant Trastuzumab

Onkologie ◽  
2013 ◽  
Vol 36 (10) ◽  
pp. 554-558 ◽  
Author(s):  
Onder Tonyali ◽  
Ugur Coskun ◽  
Nur Sener ◽  
Mevlude Inanc ◽  
Tulay Akman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Recurrence Free Survival ◽  
Her2 Positive ◽  
Adjuvant Trastuzumab ◽  
Free Survival

scholarly journals Adjuvant trastuzumab regimen for HER2-positive early-stage breast cancer: a systematic review and meta-analysis

2019 ◽  
Vol 12 (8) ◽  
pp. 815-824 ◽  
Author(s):  
Anne Julienne Genuino ◽  
Usa Chaikledkaew ◽  
Due Ong The ◽  
Thanyanan Reungwetwattana ◽  
Ammarin Thakkinstian
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Early Stage ◽  
Meta Analysis ◽  
Early Stage Breast Cancer ◽  
Her2 Positive ◽  
Adjuvant Trastuzumab

Plasma Carotenoids and Recurrence-Free Survival in Women With a History of Breast Cancer

2005 ◽  
Vol 23 (27) ◽  
pp. 6631-6638 ◽  
Author(s):  
Cheryl L. Rock ◽  
Shirley W. Flatt ◽  
Loki Natarajan ◽  
Cynthia A. Thomson ◽  
Wayne A. Bardwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Cholesterol Concentration ◽  
Fruit Intake ◽  
Recurrence Free Survival ◽  
Carotenoid Concentration ◽  
Free Survival ◽  
History Of ◽  
Breast Cancer Event

Purpose Previous studies suggest that diet may affect recurrence or survival rates in women who have been diagnosed with breast cancer. The purpose of this study was to examine the relationship between plasma carotenoid concentration, as a biomarker of vegetable and fruit intake, and risk for a new breast cancer event in a cohort of women with a history of early-stage breast cancer. Methods Participants were 1,551 women previously treated for breast cancer who were randomly assigned to the control arm of a diet intervention trial between March 1995 and November 2000. Outcome events were probed during semiannual interviews and verified by medical record review. During the period under study, 205 women had a recurrence or new primary breast cancer. Plasma carotenoid concentrations were measured in baseline blood samples. Hazard ratios (HR) and 95% CIs by quartiles of plasma carotenoids were computed, controlling for tumor stage, grade, and hormone receptor status; chemotherapy and tamoxifen therapy; clinical site; age at diagnosis; body mass index; and plasma cholesterol concentration. Results Women in the highest quartile of plasma total carotenoid concentration had significantly reduced risk for a new breast cancer event (HR, 0.57; 95% CI, 0.37 to 0.89), controlled for covariates influencing breast cancer prognosis. Conclusion Plasma carotenoids are a biologic marker of intake of vegetables and fruit, so this observation supports findings from previous studies that have linked increased vegetable and fruit intake with greater likelihood of recurrence-free survival in women who have been diagnosed with early-stage breast cancer.

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