Antiphospholipid Antibodies and Cerebellar Ataxia: A Clinical Analysis and Literature Review

2014 ◽  
Vol 21 (6) ◽  
pp. 283-290 ◽  
Author(s):  
Wei-Hsi Chen ◽  
Chang-Hung Chen ◽  
Chi Chui ◽  
Chun-Chung Lui ◽  
Chung-Jen Chen ◽  
...  
Keyword(s):  
Literature Review ◽  
Cerebellar Ataxia ◽  
Antiphospholipid Antibodies ◽  
Clinical Analysis

scholarly journals Ornidazole-Induced Recurrent Encephalopathy in a Chinese Man: A Rare Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Rong Tang ◽  
Jia Liang ◽  
Yuanfang Li ◽  
Tingting Wu ◽  
Yuhao Zhang ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Corpus Callosum ◽  
Cerebellar Ataxia ◽  
Drug Withdrawal ◽  
Clinical Manifestations ◽  
Good Prognosis ◽  
Drug Discontinuation ◽  
Imaging Features ◽  
Mental Symptoms

Ornidazole-induced encephalopathy (OIE) is seldom seen in the clinic. In this study, we report a new case of a patient who had taken 1,000 mg ornidazole daily for nearly 4 years because of suspected diarrhea and proctitis and presented with subacute symptoms such as unsteady gait, slurred speech, and psychiatric disorder. These symptoms were significantly relieved 3 days after the patient stopped taking ornidazole. When he took this medicine again, however, similar symptoms occurred 4 months later, which were again reduced after 4 days of drug discontinuation. After the second onset, abnormal signals were identified around the aqueduct of the midbrain, around the fourth ventricle, and in the dentate nuclei of the cerebellum bilaterally. After 9 days of drug discontinuation, lesions disappeared in the magnetic resonance imaging (MRI) results. According to the clinical manifestations, imaging features, and the reduced symptoms after drug withdrawal, we clinically diagnosed the patient with OIE. This paper also reviews the literature on OIE. Only five cases (including our case) have been reported, all of whom presented with cerebellar ataxia and dysarthria and three with additional mental symptoms such as agitation and irritability. All five patients had abnormal lesions in the dentate nucleus of the cerebellum bilaterally, among whom four also had lesions in the corpus callosum and three around the periaqueduct of the midbrain. After withdrawal of ornidazole, the symptoms in all patients vanished or were alleviated, and three of them showed reduced or disappeared lesions in a head MRI reexamination. Overall, OIE has rarely been reported. Our case report and literature review show that the lesions in the cerebellum, corpus callosum, and brainstem can be reversed. The main manifestations of the lesions—cerebellar ataxia, dysarthria, and mental symptoms—quickly weaken or disappear after drug withdrawal, with good prognosis. Nevertheless, clear pathogenesis has yet to be further investigated.

scholarly journals Transient Antiphospholipid Syndrome Associated with Primary Cytomegalovirus Infection: A Case Report and Literature Review

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tsuyoshi Nakayama ◽  
Mitsuteru Akahoshi ◽  
Kensuke Irino ◽  
Yasutaka Kimoto ◽  
Yojiro Arinobu ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Case Report ◽  
Literature Review ◽  
Antiphospholipid Antibodies ◽  
Cytomegalovirus Infection ◽  
Cmv Infection ◽  
Primary Cytomegalovirus Infection ◽  
First Time ◽  
Acute Cytomegalovirus

Viral infection is known to induce transient autoimmunity in humans. Acute cytomegalovirus (CMV) infection is implicated in occasional thrombosis formation. We here, for the first time, report a 19-year-old female who had an acute CMV infection, leading to a deep venous thrombosis and a pulmonary embolism along with transient appearance of lupus anticoagulant. The pathological role of antiphospholipid antibodies in CMV-mediated thrombosis is discussed.

Disulfiram neuro-toxicity: a review and report of a case of fluctuating neuro-encephalopathy

1991 ◽  
Vol 8 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Marcus Webb
Keyword(s):  
Peripheral Neuropathy ◽  
Literature Review ◽  
Cerebellar Ataxia ◽  
Clinical Course ◽  
Chronic Alcoholism ◽  
Toxic Effects ◽  
Anxiety And Depression ◽  
Rare Combination ◽  
Grand Mal

AbstractA case of chronic disulfiram (Antabuse) toxicity is described, in the context of a literature review, apparently the first such description from Ireland. The rare combination of encephalopathy with peripheral neuropathy occurred in this case, along with other probably related features. These included a fluctuating clinical course, cerebellar ataxia, grand mal seizures, impotence and a delay in improvement on discontinuing disulfiram. It is likely that symptoms of anxiety and depression in this man were also in part induced by disulfiram toxicity, but interpretation of events is complicated by developing arteriosclerosis. The difficulties in distinguishing toxic effects of disulfiram from complications of chronic alcoholism are emphasized, with resulting delay in recognizing disulfiram toxicity.

scholarly journals Cerebellar ataxia following prolonged use of metronidazole: case report and literature review

2008 ◽  
Vol 12 (6) ◽  
pp. e111-e114 ◽  
Author(s):  
Kalpeshkumar Patel ◽  
Israel Green-Hopkins ◽  
Stanley Lu ◽  
Allan R. Tunkel
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cerebellar Ataxia

Clinical analysis and literature review of massive Duodenal diverticular bleeding

2001 ◽  
Vol 25 (7) ◽  
pp. 848-855 ◽  
Author(s):  
Wen-Yao Yin ◽  
Hwa-Tzong Chen ◽  
Shih-Ming Huang ◽  
Hsien-Hong Lin ◽  
Tzu-Ming Chang
Keyword(s):  
Literature Review ◽  
Clinical Analysis ◽  
Diverticular Bleeding

Continuous Traumatic Situations in the Face of Ongoing Political Violence

2016 ◽  
Vol 17 (5) ◽  
pp. 562-570 ◽  
Author(s):  
Orit Nuttman-Shwartz ◽  
Yael Shoval-Zuckerman
Keyword(s):  
Literature Review ◽  
National Security ◽  
Political Violence ◽  
Psychological Impact ◽  
Extended Period ◽  
Clinical Analysis ◽  
Emotional Reactions ◽  
Traumatic Experiences ◽  
Future Research ◽  
Security Threats

This article presents a literature review of the concept of continuous traumatic situations (CTS), which relates to residents living in ongoing situations of political violence and national security threats. The first aim of this review is to narrow the gap regarding knowledge about the concept of CTS by presenting findings from studies that have assessed the effects of CTS on civilian populations. The second aim is to describe CTS in a way that highlights the differences and similarities between posttraumatic stress disorder and responses to CTS. This distinction is a necessary precondition for examining CTS, as is a careful clinical analysis of the development and course of symptoms. This literature review also highlights the importance of adopting a supplementary perspective for understanding the psychological impact of ongoing exposure to real threats, which can be used as a basis for developing intervention strategies that are appropriate for coping with life in the context of persistent violence. CTS can be manifested as emotions, behaviors, and perceptions among individuals, families, communities, and societies. The nature of the proposed model of CTS is a circular one, combining past and future perceptions and emotional reactions that have resulted from continuous and repeated traumatic experiences over an extended period of time. This wider understanding reflects the complexity of the CTS phenomenon. Various micro and macro interventions relating to CTS as the result of political violence situations and national security threats are presented, and recommendations for practice, policy, and future research are offered.

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