scholarly journals The G Protein-Coupled Estrogen Receptor 1 (GPER1/GPR30) Agonist G-1 Regulates Vascular Smooth Muscle Cell Ca2+Handling

2013 ◽  
Vol 50 (5) ◽  
pp. 421-429 ◽  
Author(s):  
Anders Holm ◽  
Per Hellstrand ◽  
Björn Olde ◽  
Daniel Svensson ◽  
L.M. Fredrik Leeb-Lundberg ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
G Protein ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

G protein-coupled receptors control vascular smooth muscle cell proliferation via pp60c-src and p21ras

1997 ◽  
Vol 272 (6) ◽  
pp. C2019-C2030 ◽  
Author(s):  
B. Schieffer ◽  
H. Drexler ◽  
B. N. Ling ◽  
M. B. Marrero
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
G Protein ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
G Protein Coupled Receptors ◽  
Smooth Muscle Cell Proliferation ◽  
G Protein Coupled

The binding of vasoactive peptides to their respective G protein-coupled receptors has been implicated in the pathogenesis of vascular smooth muscle cell proliferation, leading to the development of hypertension, arteriosclerosis, and restenosis after vascular injury. We previously showed that the cytosolic tyrosine kinase pp60c-src is crucial for angiotensin II (ANG II)-induced activation of the protooncogene p21ras. Therefore, we investigated the role of pp60c-src and p21ras in rat aortic smooth muscle cell proliferation induced by several G protein-coupled receptors. ANG II, endothelin-1, or thrombin increased cell proliferation and DNA synthesis. Electroporation of anti-pp60c-src antibodies into cells abolished proliferation in response to these G protein-coupled receptor ligands but not in response to platelet-derived growth factor-BB (PDGF-BB). In contrast, electroporation of anti-p21ras antibody completely blocked DNA synthesis and cell proliferation in response to ANG II, endothelin-1, thrombin, and PDGF-BB. Our data indicate that the pp60c-src tyrosine kinase is necessary and specific for vascular smooth muscle cell proliferation and DNA synthesis in response to G protein-coupled receptors but not classic growth factor receptors.

scholarly journals Characterization of a G Protein-activated Phosphoinositide 3-Kinase in Vascular Smooth Muscle Cell Nuclei

2001 ◽  
Vol 276 (25) ◽  
pp. 22170-22176 ◽  
Author(s):  
Daniel Bacqueville ◽  
Paul Déléris ◽  
Christiane Mendre ◽  
Marie-Thérèse Pieraggi ◽  
Hugues Chap ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
G Protein ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Nuclei ◽  
Phosphoinositide 3 Kinase
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