Beneficial Effects of Vildagliptin on Retinal Injury in Obese Type 2 Diabetic Rats

2013 ◽  
Vol 50 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Satoshi Maeda ◽  
Sho-ichi Yamagishi ◽  
Takanori Matsui ◽  
Sae Nakashima ◽  
Ayako Ojima ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Beneficial Effects ◽  
Retinal Injury ◽  
Type 2 Diabetic

scholarly journals Antioxidant and Renoprotective Effects ofSpirogyra neglecta(Hassall) Kützing Extract in Experimental Type 2 Diabetic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Atcharaporn Ontawong ◽  
Naruwan Saowakon ◽  
Pornpun Vivithanaporn ◽  
Anchalee Pongchaidecha ◽  
Narissara Lailerd ◽  
...  
Keyword(s):  
Organic Anion ◽  
Diabetic Rats ◽  
Organic Anion Transporter ◽  
Renal Transport ◽  
Type 2 Diabetic Mellitus ◽  
Beneficial Effects ◽  
Anion Transporter ◽  
Renal Morphology ◽  
Type 2 Diabetic

Spirogyra neglectaextract (SNE) has shown antihyperglycemia and antihyperlipidemia in type 2 diabetic mellitus (T2DM) rats. This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin. T2DM rats were fed daily with SNE (0.25, 0.5, and 1 g/kg BW) for 12 weeks. Renal morphology, malondialdehyde levels, qPCR, and western blotting were analyzed. Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate andpara-aminohippurate, mediated through organic anion transporter 3-Oat3. Insulin and PKCζwere known to activate Oat3 function while it was inhibited by PKCα. Compared to T2DM, plasma glucose, triglyceride, insulin resistance, renal morphology, and malondialdehyde levels were significantly improved by SNE supplementation. Reduced glutathione peroxidase and nuclear factorκB expressions were related to antioxidant effect of SNE. Oat3 mRNA and protein were not different among groups, but insulin-stimulated rOat3 followed by anion uptakes was abolished in T2DM. This was restored in the slices from SNE treatment. The mechanism of SNE-improved Oat3 was associated with PKCαand PKCζexpressions and activities. These findings indicate that SNE has beneficial effects on renal transport through antioxidant enzymes and PKCs in T2DM rats.

Beneficial Effects of Swertiamarin on Dyslipidaemia in Streptozotocin-induced Type 2 Diabetic Rats

2012 ◽  
Vol 26 (8) ◽  
pp. 1259-1261 ◽  
Author(s):  
Hitesh Vaidya ◽  
Alpesh Prajapati ◽  
Mandapati Rajani ◽  
Vasudevan Sudarsanam ◽  
Harish Padh ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Beneficial Effects ◽  
Type 2 Diabetic

scholarly journals Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Remmelt Van der Werf ◽  
Catherine Walter ◽  
William Bietiger ◽  
Elodie Seyfritz ◽  
Carole Mura ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Vascular Complications ◽  
Diabetic Rats ◽  
Beneficial Effects ◽  
Type 2 Diabetic

scholarly journals Escitalopram Ameliorates Cardiomyopathy in Type 2 Diabetic Rats via Modulation of Receptor for Advanced Glycation End Products and Its Downstream Signaling Cascades

2020 ◽  
Vol 11 ◽  
Author(s):  
Lamiaa A. Ahmed ◽  
Nesma A. Shiha ◽  
Amina S. Attia
Keyword(s):  
Glycemic Control ◽  
Advanced Glycation End Products ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Advanced Glycation ◽  
Beneficial Effects ◽  
Glycation End Products ◽  
End Products ◽  
Type 2 Diabetic

Type 2 diabetes mellitus (T2DM) has been recognized as a known risk factor for cardiovascular diseases. Additionally, studies have shown the prevalence of depression among people with diabetes. Thus, the current study aimed to investigate the possible beneficial effects of escitalopram, a selective serotonin reuptake inhibitor, on metabolic changes and cardiac complications in type 2 diabetic rats. Diabetes was induced by feeding the rats high fat-high fructose diet (HFFD) for 8 weeks followed by a subdiabetogenic dose of streptozotocin (STZ) (35 mg/kg, i. p.). Treatment with escitalopram (10 mg/kg/day; p. o.) was then initiated for 4 weeks. At the end of the experiment, electrocardiography was performed and blood samples were collected for determination of glycemic and lipid profiles. Animals were then euthanized and heart samples were collected for biochemical and histopathological examinations. Escitalopram alleviated the HFFD/STZ-induced metabolic and cardiac derangements as evident by improvement of oxidative stress, inflammatory, fibrogenic and apoptotic markers in addition to hypertrophy and impaired conduction. These results could be secondary to its beneficial effects on the glycemic control and hence the reduction of receptor for advanced glycation end products content as revealed in the present study. In conclusion, escitalopram could be considered a favorable antidepressant medication in diabetic patients as it seems to positively impact the glycemic control in diabetes in addition to prevention of its associated cardiovascular complications.

Chronic resveratrol administration has beneficial effects in experimental model of type 2 diabetic rats.

2012 ◽  
Vol 46 (02) ◽  
pp. 83-90 ◽  
Author(s):  
F. G. Soufi ◽  
R. Sheervalilou ◽  
M. Vardiani ◽  
M. Khalili ◽  
M. R. Alipour
Keyword(s):  
Experimental Model ◽  
Diabetic Rats ◽  
Beneficial Effects ◽  
Type 2 Diabetic

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

Neuroprotection of Maslinic Acid, a Novel Glycogen Phos-phorylase Inhibitor, in Type 2 Diabetic Rats

2010 ◽  
Vol 8 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Teng GUAN ◽  
Yi-Song QIAN ◽  
Meng-Hao HUANG ◽  
Long-Fei HUANG ◽  
Xu-Zhen TANG ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Maslinic Acid ◽  
Type 2 Diabetic
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