scholarly journals Acute Myocardial Infarction Caused by Tumor-Associated Thrombotic Thrombocytopenic Purpura: Case Report

2014 ◽  
Vol 23 (3) ◽  
pp. 289-291 ◽  
Author(s):  
Jun Wang ◽  
Xiaomin Cai ◽  
Xunmin Cheng ◽  
Ping Song ◽  
Shisen Jiang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals Acute myocardial infarction and extensive systemic thrombosis in thrombotic thrombocytopenic purpura: A case report and review of literature

2021 ◽  
Vol 9 (27) ◽  
pp. 8104-8113
Author(s):  
Delia Lidia Șalaru ◽  
Cristina Andreea Adam ◽  
Dragos Traian Marius Marcu ◽  
Ionut Valentin Șimon ◽  
Liviu Macovei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Review Of Literature ◽  
Thrombocytopenic Purpura

scholarly journals Risk-Predictors of Mortality in Hospitalized Patients with Thrombotic Thrombocytopenic Purpura: Nationally Representative Data from 2007-2011

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4290-4290
Author(s):  
Ruchika Goel ◽  
Paul Ness ◽  
Clifford M. Takemoto ◽  
Karen E. King ◽  
Aaron Tobian
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Logistic Regression ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Arterial Thrombosis ◽  
Hospitalized Patients ◽  
Thrombocytopenic Purpura ◽  
Plasma Infusion ◽  
Multivariable Logistic Regression

Abstract Introduction: Survivors of Thrombotic Thrombocytopenic Purpura (TTP) hospitalizations have been proposed to be at higher risk for long term poor clinical outcomes and premature death. Patients with TTP have a high risk for in-hospital morbidity and mortality as well. However, there is a paucity of data on the predictors of adverse outcomes including death in hospitalized patients with TTP. Methods: A weighted analysis of 5 years (2007-2011) using data from the Nationwide Inpatient Sample, a stratified probability sample of 20% of all hospital discharges among community hospitals in the United States (approximately 1100 hospitals/year), was performed. Hospitalizations with TTP as the primary admitting diagnoses were identified using the ICD-9 discharge code 446.6. Univariate and stepwise multivariable logistic regression analyses with elimination were used for statistical analysis. Based on results of univariate analysis, the significant variables were added in a stepwise manner in a multivariable model. All variables selected for the multivariable model were tested for interaction with a significance threshold level of p<0.2. Except for this, all hypothesis testing was two tailed and p<0.05 was considered significant. Receiver Operator Characteristics (ROC) curve was constructed using risk factors on multivariate analysis. Results: The all-cause mortality rate was 8.7% (918/10615) among admissions with primary diagnosis of TTP (0.5% pediatric, 65.9% female, 58.2% Caucasian, 27.2% African-American). Table 1 lists the risk factors by univariate analysis and includes a) factors with significantly higher odds of mortality and b) other putative factors which were not statistically significant predictors. Table 2: In stepwise multivariable logistic regression analysis: arterial thrombosis (adjOR 5.1 95%CI=1.1-31.7), acute myocardial infarction (adjOR 2.8, 95%CI=1.6-4.9), non-occurrence of either intervention: plasmapheresis or fresh frozen plasma infusion (adjOR 2.0, 95% CI=1.4-2.9) 4) requirement of platelet transfusions during hospitalization (adjOR 2.0, 95%CI= 1.3-3.2) and every ten year increase in age (OR 1.4 95%CI=1.3-1.6) were independently predictive of mortality in TTP patients (area under the curve for ROC 74%, Figure 1). Conclusion: We present a set of independent risk factors that may potentially be used in a predictive model of mortality in TTP. Early and targeted aggressive therapy based on these factors should guide the management of hospitalized patients with TTP for improved outcomes. Table 1.Unadjusted odds of in-hospital mortality.Significant predictors of mortality for TTP on univariate analysisOdds Ratio95% Confidence LimitsArterial Thrombosis 10.92.254.6AMI 3.72.16.2STROKE 4.93.07.9Platelet Transfusion 2.31.53.6Bleeding event 1.71.12.6Plasmapheresis (No vs. Yes)1.61.22.3plasmapheresis or plasma infusion (not performed)2.21.53.1Every 10 years increase in age1.51.31.6PRBC transfusion1.71.22.3Caucasian versus African American1.91.32.8Asian versus African American3.31.29.1V ariables not significant predictors of mortality for TTP on univariate analysis.Odds Ratio95% Confidence LimitsVenous Thrombosis/Thromboembolism1.90.84.4FEMALE versus male gender1.00.71.4Hypertension Yes vs. no0.90.61.2Diabetes Yes vs. no0.90.61.4Chronic Kidney Disease Yes vs. No1.40.92.2End Stage Renal Disease Yes vs. No0.90.41.9Overweight/Obese Yes vs. No0.70.41.5Variables meeting criteria for inclusion in multiple logistic regression model are in boldface type. Table 2. Multivariable Predictors for In Hospital Mortality in patients with primary diagnosis of TTP Adjusted Odds Ratio 95% Confidence Limits Arterial Thrombosis 6.0 1.2 30.5 Acute myocardial infarction 2.8 1.6 4.8 No Plasmapheresis/Plasma infusion 2.0 1.4 2.9 Platelet Transfusion 2.1 1.4 3.2 Age (per 10 year higher) 1.4 1.3 1.6 Female versus Male 1.2 0.8 1.7 TTP = Thrombotic Thrombocytopenic Purpura Step 0: Using arterial thrombosis Figure 1: Receiver- Operator-Characteristic Curve (ROC) overlay curve for the stepwise multivariable logistic regression risk prediction showing incremental AUC with addition of each risk factor for hospital patients with TTP. Figure 1:. Receiver- Operator-Characteristic Curve (ROC) overlay curve for the stepwise multivariable logistic regression risk prediction showing incremental AUC with addition of each risk factor for hospital patients with TTP. Step 1: Adding acute myocardial infarction Step 2: Adding plasmapheresis /fresh frozen plasma infusion Step 3: Adding platelet transfusions Final model: Adding every ten year increase in age. Disclosures Ness: Terumo BCT: Consultancy.

Predictors of In-hospital Mortality and Acute Myocardial Infarction in Thrombotic Thrombocytopenic Purpura

2013 ◽  
Vol 126 (11) ◽  
pp. 1016.e1-1016.e7 ◽  
Author(s):  
Nivas Balasubramaniyam ◽  
Dhaval Kolte ◽  
Chandrasekar Palaniswamy ◽  
Kiran Yalamanchili ◽  
Wilbert S. Aronow ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

Acute myocardial infarction as the initial thrombotic event of thrombotic thrombocytopenic purpura

2016 ◽  
Vol 27 (8) ◽  
pp. 948-951 ◽  
Author(s):  
Tomoko Takimoto ◽  
Mitsushige Nakao ◽  
Takuya Nakajo ◽  
Yoshiaki Chinen ◽  
Junya Kuroda ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Event ◽  
Thrombocytopenic Purpura

PREVALENCE OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 109S
Author(s):  
Kaushang A. Gandhi ◽  
Wilbert S. Aronow ◽  
Parminder Singh ◽  
Harit Desai ◽  
Harshad Amin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED ACUTE MYOCARDIAL INFARCTION

2018 ◽  
Vol 5 (3) ◽  
pp. 183
Author(s):  
Betül Çavuşoğlu Türker ◽  
Süleyman Ahbab ◽  
Fatih Türker ◽  
Hayriye Esra Ataoğlu
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

A case of thrombotic thrombocytopenic purpura(TTP) presented with acute myocardial infarction(AMI)

1993 ◽  
Vol 23 (3) ◽  
pp. 481
Author(s):  
Cheol Whan Lee ◽  
Jae Joong Kim ◽  
Sung Jae Myung ◽  
Ju Young Kim ◽  
Hae Hyuk Chung ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura
Sign in / Sign up

Export Citation Format

Share Document