Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

Dermatology ◽  
2013 ◽  
Vol 227 (3) ◽  
pp. 214-225 ◽  
Author(s):  
Filippo Piffaretti ◽  
Matthieu Zellweger ◽  
Behrooz Kasraee ◽  
Jérôme Barge ◽  
Denis Salomon ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Outcome ◽  
Fluorescence Intensity ◽  
Actinic Keratosis ◽  
Protoporphyrin Ix

Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome

2004 ◽  
Vol 151 (6) ◽  
pp. 1204-1212 ◽  
Author(s):  
M.B. Ericson ◽  
C. Sandberg ◽  
B. Stenquist ◽  
F. Gudmundson ◽  
M. Karlsson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Outcome ◽  
Actinic Keratosis

scholarly journals Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy

Cancers ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 72 ◽  
Author(s):  
Jessica Tyrrell ◽  
Cheryl Paterson ◽  
Alison Curnow
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Outcome ◽  
Imaging System ◽  
Protoporphyrin Ix ◽  
Air Cooling ◽  
Non Invasive ◽  
Fold Reduction ◽  
Methyl Aminolevulinate ◽  
Superficial Basal Cell Carcinoma ◽  
Hands And Feet

Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasive imaging system during routine methyl aminolevulinate (MAL)-PDT treatment of 172 patients with licensed dermatological indications (37.2% actinic keratosis, 27.3% superficial basal cell carcinoma and 35.5% Bowen’s disease). Linear and logistic regressions were employed to model any relationships between variables that may have affected PpIX accumulation and/or PpIX photobleaching during irradiation and thus clinical outcome at three months. Patient age was found to be associated with lower PpIX accumulation/photobleaching, however only a reduction in PpIX photobleaching appeared to consistently adversely affect treatment efficacy. Clinical clearance was reduced in lesions located on the limbs, hands and feet with lower PpIX accumulation and subsequent photobleaching adversely affecting the outcome achieved. If air cooling pain relief was employed during light irradiation, PpIX photobleaching was lower and this resulted in an approximate three-fold reduction in the likelihood of achieving clinical clearance. PpIX photobleaching during the first treatment was concluded to be an excellent predictor of clinical outcome across all lesion types.

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

Evaluation of Therapeutic Effectiveness of Photodynamic Therapy (PDT) Using Metal Halide Lamp for Actinic Keratosis and Bowen's Disease

2011 ◽  
Vol 73 (3) ◽  
pp. 260-265
Author(s):  
Toshinori BITO ◽  
Shun OHMORI ◽  
Mayuko YOSHIZAWA ◽  
Sanehito HARUYAMA ◽  
Yu SAWADA ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Actinic Keratosis ◽  
Metal Halide ◽  
Therapeutic Effectiveness ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Metal Halide Lamp
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