Strategies and Challenges for Systematically Mapping Biologically Significant Molecular Pathways Regulating Carcinoma Epithelial-Mesenchymal Transition

2013 ◽  
Vol 197 (6) ◽  
pp. 424-434 ◽  
Author(s):  
Nur Akmarina B.M. Said ◽  
Kaylene J. Simpson ◽  
Elizabeth D. Williams
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Molecular Pathways ◽  
Mesenchymal Transition

scholarly journals Overview of Evidence-Based Chemotherapy for Oral Cancer: Focus on Drug Resistance Related to the Epithelial-Mesenchymal Transition

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 893
Author(s):  
Jingjing Sha ◽  
Yunpeng Bai ◽  
Huy Xuan Ngo ◽  
Tatsuo Okui ◽  
Takahiro Kanno
Keyword(s):  
Drug Resistance ◽  
Transcription Factors ◽  
Oral Cancer ◽  
High Throughput Screening ◽  
Epithelial Mesenchymal Transition ◽  
Chemotherapeutic Agents ◽  
Signal Pathways ◽  
Evidence Based ◽  
Molecular Pathways ◽  
Mesenchymal Transition

The increasing incidence of resistance to chemotherapeutic agents has become a major issue in the treatment of oral cancer (OC). Epithelial-mesenchymal transition (EMT) has attracted a great deal of attention in recent years with regard to its relation to the mechanism of chemotherapy drug resistance. EMT-activating transcription factors (EMT-ATFs), such as Snail, TWIST, and ZEB, can activate several different molecular pathways, e.g., PI3K/AKT, NF-κB, and TGF-β. In contrast, the activated oncological signal pathways provide reciprocal feedback that affects the expression of EMT-ATFs, resulting in a peritumoral extracellular environment conducive to cancer cell survival and evasion of the immune system, leading to resistance to multiple chemotherapeutic agents. We present an overview of evidence-based chemotherapy for OC treatment based on the National Comprehensive Cancer Network (NCCN) Chemotherapy Order Templates. We focus on the molecular pathways involved in drug resistance related to the EMT and highlight the signal pathways and transcription factors that may be important for EMT-regulated drug resistance. Rapid progress in antitumor regimens, together with the application of powerful techniques such as high-throughput screening and microRNA technology, will facilitate the development of therapeutic strategies to augment chemotherapy.

scholarly journals Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance

2020 ◽  
Vol 21 (11) ◽  
pp. 4002 ◽  
Author(s):  
Milad Ashrafizadeh ◽  
Ali Zarrabi ◽  
Kiavash Hushmandi ◽  
Mahshad Kalantari ◽  
Reza Mohammadinejad ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Epithelial Mesenchymal Transition ◽  
Therapy Resistance ◽  
Nuclear Factor Κb ◽  
Molecular Pathways ◽  
Cancer Resistance ◽  
Mesenchymal Transition ◽  
The Impact

Therapy resistance is a characteristic of cancer cells that significantly reduces the effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent, which is widely used in the treatment of various types of cancer, resistance of cancer cells to CP chemotherapy has been extensively observed. Among various reported mechanism(s), the epithelial–mesenchymal transition (EMT) process can significantly contribute to chemoresistance by converting the motionless epithelial cells into mobile mesenchymal cells and altering cell–cell adhesion as well as the cellular extracellular matrix, leading to invasion of tumor cells. By analyzing the impact of the different molecular pathways such as microRNAs, long non-coding RNAs, nuclear factor-κB (NF-ĸB), phosphoinositide 3-kinase-related protein kinase (PI3K)/Akt, mammalian target rapamycin (mTOR), and Wnt, which play an important role in resistance exhibited to CP therapy, we first give an introduction about the EMT mechanism and its role in drug resistance. We then focus specifically on the molecular pathways involved in drug resistance and the pharmacological strategies that can be used to mitigate this resistance. Overall, we highlight the various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure.

scholarly journals A Comprehensive Review: Molecular and Genetic Background of Indirect Inguinal Hernias

2021 ◽  
pp. 1-9
Author(s):  
Salih Somuncu ◽  
Özge Sezin Somuncu
Keyword(s):  
Genetic Background ◽  
Epithelial Mesenchymal Transition ◽  
Genetic Diseases ◽  
Testicular Descent ◽  
Molecular Pathways ◽  
Processus Vaginalis ◽  
Comprehensive Review ◽  
Mesenchymal Transition ◽  
Inguinal Hernias ◽  
Comprehensive Study

<b><i>Background:</i></b> The occurrence of indirect inguinal hernias (IIH) is 5 times more prevalent than that of direct inguinal hernias (IH) and it is 7 times more common in males, owing to the attendance of the processus vaginalis (PV) throughout testicular descent. <b><i>Summary:</i></b> In children, the immense mainstream of IH is indirect. The progress of IIH development in children is instigated with a patent PV, which is mostly treated by simple herniorrhaphy. Syndromes of the collagen, microfibril, elastin, and glycosaminoglycan constituents of the extracellular matrix may attend to the development of IH. Our recent research showed that the lack of epithelial-mesenchymal transition (EMT) in children contributes to the development of IIH, while the scenario is defined as the opposite in adults. However, there is still a lack of knowledge on all of the genetic and molecular causes of the disease. <b><i>Key Messages:</i></b> Here we aimed to review the published genetic background of IH, the deficiencies of connective tissue causing the disease, recently defined molecular pathways involved including EMT, and possible recurrence reasons. This comprehensive study can deliver an analytic outline aiding to define patients with IH combined with fundamental genetic diseases.

Sign in / Sign up

Export Citation Format

Share Document