Human Hepatocyte Transplantation in Patients with Hepatic Failure Awaiting a Graft

2013 ◽  
Vol 50 (3-4) ◽  
pp. 273-281 ◽  
Author(s):  
E. Pareja ◽  
M.J. Gomez-Lechon ◽  
M. Cortes ◽  
A. Bonora-Centelles ◽  
J.V. Castell ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Human Hepatocyte ◽  
Hepatocyte Transplantation

scholarly journals Primary human hepatocyte transplantation in the therapy of hepatic failure: 2 cases report

2012 ◽  
Vol 5 (2) ◽  
pp. 165-168 ◽  
Author(s):  
Zhuo-Ri Li ◽  
Xian-Hai Mao ◽  
Xiao-Xuan Hu ◽  
Sheng-Dan Nie ◽  
Yong-Zhong Shi ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Human Hepatocyte ◽  
Hepatocyte Transplantation ◽  
Primary Human Hepatocyte

Studies on the Safety of Intrasplenic Hepatocyte Transplantation: Relevance toEx VivoGene Therapy and Liver Repopulation in Acute Hepatic Failure

1993 ◽  
Vol 4 (3) ◽  
pp. 249-257 ◽  
Author(s):  
Sanjeev Gupta ◽  
Purnachandra R. Yerneni ◽  
Ravikumar P. Vemuru ◽  
Chang-Don Lee ◽  
Edward L. Yellin ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatocyte Transplantation ◽  
Liver Repopulation

Human Hepatocyte Transplantation

2010 ◽  
pp. 525-534 ◽  
Author(s):  
Anil Dhawan ◽  
Stephen C. Strom ◽  
Etienne Sokal ◽  
Ira J. Fox
Keyword(s):  
Human Hepatocyte ◽  
Hepatocyte Transplantation

ALLOGENEIC AND XENOGENEIC HEPATOCYTE TRANSPLANTATION IN EXPERIMENTAL HEPATIC FAILURE

1980 ◽  
Vol 30 (6) ◽  
pp. 429-435 ◽  
Author(s):  
LEONARD MAKOWKA ◽  
LORNE E. ROTSTEIN ◽  
RUDOLPH E. FALK ◽  
JUDITH A. FALK ◽  
NATALIE A. NOSSAL ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Hepatocyte Transplantation

Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure

1986 ◽  
Vol 166 (1) ◽  
pp. 139-150 ◽  
Author(s):  
E. Gohda ◽  
H. Tsubouchi ◽  
H. Nakayama ◽  
S. Hirono ◽  
K. Takahashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Human Hepatocyte ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

Three Different Hepatocyte Transplantation Techniques for Enzyme Deficiency Disease and Acute Hepatic Failure

1992 ◽  
Vol 16 (5) ◽  
pp. 522-526 ◽  
Author(s):  
Anje A. Velde ◽  
Diederik K. Bosman ◽  
Jeroen Oldenburg ◽  
Mieke Sala ◽  
Martinus A.W. Maas ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatocyte Transplantation ◽  
Enzyme Deficiency ◽  
Deficiency Disease

scholarly journals Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London

2012 ◽  
Vol 21 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Juliana Puppi ◽  
Stephen C. Strom ◽  
Robin D. Hughes ◽  
Sanjay Bansal ◽  
Jose V. Castell ◽  
...  
Keyword(s):  
Consensus Meeting ◽  
Human Hepatocyte ◽  
Hepatocyte Transplantation

Human Hepatocyte Transplantation: Gene Therapy and More?

PEDIATRICS ◽  
1998 ◽  
Vol 102 (3) ◽  
pp. 647-648 ◽  
Author(s):  
J. R. Chowdhury ◽  
N. R. Chowdhury ◽  
S. C. Strom ◽  
S. S. Kaufman ◽  
S. Horslen ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Human Hepatocyte ◽  
Hepatocyte Transplantation

In Vivo Identification, Survival, and Functional Efficacy of Transplanted Hepatocytes in Acute Liver Failure Mice Model by Fish Using Y-Chromosome Probe

1998 ◽  
Vol 7 (3) ◽  
pp. 267-273 ◽  
Author(s):  
Donkena Krishna Vanaja ◽  
Bhattiprolu Sivakumar ◽  
Rachel A. Jesudasan ◽  
Lalji Singh ◽  
Marasanapalle Kalle Janardanasarma ◽  
...  
Keyword(s):  
Overall Survival ◽  
Y Chromosome ◽  
Hepatic Failure ◽  
Periodic Acid ◽  
Mineral Oil ◽  
Hepatocyte Transplantation ◽  
Control Group ◽  
Mice Model ◽  
Liver Support ◽  
Fish Technique

Hepatocyte transplantation has excited much interest in lending temporary metabolic support to a failing liver following acute liver injury. The exact site from which they act and the clinical, biochemical, and histological changes in the recipient body following hepatocyte transplantation is yet to be worked out. The present study is an attempt to delineate location and function of transplanted hepatocytes and also the overall survival of these cells with a fluorescent in situ hybridization (FISH) technique using a Y-chromosome–specific probe in a carbon tetrachloride (CCl4)-induced mice model of fulminant hepatic failure. Fifty-five syngenic adult Swiss female mice of approximately the same age and body weight were divided into three groups. Group-1 (n = 15), which received mineral oil, served as a negative control. Group-II (n = 15) received CCl4 (3 mL/kg) 40% vol/vol in mineral oil, by gavage served as positive control for hepatic failure. Group-III (n = 25) received intrasplenic transplantation of syngenic single cell suspension of hepatocytes in Hanks medium, after 30 h of CCl4 administration. Male Swiss adult mice (n = 15) served as donors of hepatocytes. The overall survival of animals in groups I to III was 100, 0, and 70%, respectively, by 2 wk of the study period. Transplanted hepatocytes were identified by Periodic Acid Schiff (PAS) staining and confirmed with a FISH technique using the Y-chromosome probe. The majority of exogenously transplanted hepatocytes were found in the liver and spleen sections even after 1 wk of hepatocyte transplantation. Transplanted cells were mostly found to be translocated into the sinusoids of the liver. Transplanted hepatocytes were found to be beneficial as a temporary liver support in a failing liver, significantly improving the survival of the animals. In the present study, the FISH technique was used to unequivocally distinguish the transplanted cells from the host, and thus describes a model for studying the distribution and survival of the transplanted cells.

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