Second-Trimester Screening for Trisomy-21 Using Prefrontal Space Ratio

2013 ◽  
Vol 34 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Petya Chaveeva ◽  
Maria Agathokleous ◽  
Leona C.Y. Poon ◽  
Desislava Markova ◽  
Kypros H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening ◽  
Space Ratio

scholarly journals Prefrontal Space Ratio—A Novel Ultrasound Marker in the Second Trimester Screening for Trisomy 21: Systematic Review and Meta-Analysis

2017 ◽  
Vol 33 (4) ◽  
pp. 269-277
Author(s):  
Mohammad Zare Mehrjardi ◽  
Elham Keshavarz
Keyword(s):  
Trisomy 21 ◽  
Meta Analysis ◽  
False Positive Rate ◽  
Ultrasound Screening ◽  
Second Trimester ◽  
Likelihood Ratios ◽  
Second Trimester Screening ◽  
Trimester Screening ◽  
Soft Marker ◽  
Space Ratio

To determine the value of prefrontal space ratio (PFSR) as a novel soft marker in the second-trimester screening for trisomy 21, PubMed and two other databases were searched electronically for the relevant materials published between January 2000 and December 2015. Four studies were included in the mini meta-analysis. All of the studies were retrospective and of high quality. Overall sample size was 293 trisomy 21 and 609 euploid fetuses. The pooled mean PFSR was 0.322 (95% confidence interval [CI], 0.256-0.388) and 1.205 (95% CI, 0.997-1.413) in trisomy 21 and euploid fetuses, respectively. This ratio was found to be significantly lower in trisomy 21 fetuses compared to euploid ones ( P < .0001). The pooled detection rate was 87.2% at a false-positive rate of 5%. Pooled positive and negative likelihood ratios measured 17.2 and 0.146, respectively. In conclusion, PFSR is an efficient marker that may be investigated in the second-trimester ultrasound screening for trisomy 21.

SECOND TRIMESTER SCREENING FOR TRISOMY 21

The Lancet ◽  
1989 ◽  
Vol 334 (8653) ◽  
pp. 52 ◽  
Author(s):  
R. Osathanondh ◽  
J.A. Canick ◽  
K.B. Abell ◽  
L.D. Stevens ◽  
G.E. Palomaki ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Assessment of the ductus venosus, tricuspid blood flow and the nasal bone in second-trimester screening for trisomy 21

2010 ◽  
Vol 37 (4) ◽  
pp. 444-449 ◽  
Author(s):  
R. Stressig ◽  
P. Kozlowski ◽  
S. Froehlich ◽  
H. J. Siegmann ◽  
R. Hammer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Trisomy 21 ◽  
Nasal Bone ◽  
Ductus Venosus ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

scholarly journals P25.03: Effect of IVF/ICSI on second trimester screening markers

2012 ◽  
Vol 40 (S1) ◽  
pp. 264-264
Author(s):  
E. Colantuono ◽  
F. D'Antonio ◽  
M. Recchi ◽  
L. Marrone ◽  
B. Matarrelli ◽  
...  
Keyword(s):  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Agenesis of ductus venosus in sequential first and second trimester screening

2014 ◽  
Vol 34 (11) ◽  
pp. 1099-1105 ◽  
Author(s):  
D. G. Iliescu ◽  
M. L. Cara ◽  
S. Tudorache ◽  
P. Antsaklis ◽  
L. V. Novac ◽  
...  
Keyword(s):  
Ductus Venosus ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

scholarly journals VP18.10: What is the benefit of using an ultrasound checklist during a second trimester screening exam?

2021 ◽  
Vol 58 (S1) ◽  
pp. 175-175
Author(s):  
B. Deloison ◽  
G. Benoit ◽  
C. Bernabe Dupont ◽  
A. Sabine ◽  
F. Jacquemard ◽  
...  
Keyword(s):  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

scholarly journals The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

2020 ◽  
Author(s):  
AYSE OZBAN
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tests ◽  
Second Trimester ◽  
Study Results ◽  
Second Trimester Screening ◽  
Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

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