Lymphogranuloma Venereum: A Concise Outline of an Emerging Infection among Men Who Have Sex with Men

2013 ◽  
pp. 151-157
Author(s):  
Henry J.C. de Vries ◽  
Servaas Morré
Keyword(s):  
Lymphogranuloma Venereum ◽  
Emerging Infection ◽  
Sex With Men

scholarly journals Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men

2016 ◽  
Vol 22 (10) ◽  
pp. 1778-1784 ◽  
Author(s):  
Charussri Leeyaphan ◽  
Jason J. Ong ◽  
Eric P.F. Chow ◽  
Fabian Y.S. Kong ◽  
Jane S. Hocking ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

scholarly journals Lymphogranuloma venereum emerging in men who have sex with men in Germany

2006 ◽  
Vol 11 (9) ◽  
pp. 5-6 ◽  
Author(s):  
V Bremer ◽  
T Meyer ◽  
U Marcus ◽  
O Hamouda
Keyword(s):  
Lymphogranuloma Venereum ◽  
European Countries ◽  
Health Concern ◽  
Probable Case ◽  
Sexually Transmitted ◽  
Lymph Node Swelling ◽  
Male Patients ◽  
Sex With Men ◽  
Omp1 Gene ◽  
Great Public Health

A resurgence of lymphogranuloma venereum (LGV) has been observed in several European countries. LGV is not a mandatorily notifiable disease in Germany. Reports of LGV cases have actively been collected by the Robert Koch-Institut since 2004 to describe the outbreak and estimate the extent of the LGV problem in Germany. Updates on the LGV outbreak were published in the German national epidemiological bulletin. Physicians were asked to send their samples to a laboratory for genotyping. A possible case was defined as a person with symptoms of proctitis and/or inguinal lymph node swelling and a positive chlamydia serology. A probable case had in addition a positive chlamydia rectal or urinary PCR test. A case was confirmed if the genotype L1-L3 was identified based on sequence analysis of omp1 gene sequences. Since 2003, LGV has been reported in 78 male patients in Germany. Of these, 61 patients were confirmed as genotype L2. Fifty eight out of 78 patients (74%) are known to be men who have sex with men (MSM). Fifty five patients (71%) had rectal symptoms and 49 (63%) knew they were HIV positive. Sixty two (79%) of the patients were residents of Berlin or Hamburg. LGV has emerged in MSM in Germany at the same time as in other European countries. It is thought that LGV may become endemic in the MSM community in German metropolitan areas, because the number of reported patients with LGV continues to increase. The increase in the number of LGV cases and the high HIV prevalence in LGV patients are of great public health concern. Clinicians and MSM may not be sufficiently aware of the disease, and existing efforts to promote awareness and prevention of sexually transmitted infections and HIV need to be strengthened.

scholarly journals Lymphogranuloma venereum (LGV) in men who have sex with men (MSM): a re-emerging problem, Malta, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Alastair Donachie ◽  
Gianfranco Spiteri ◽  
Christopher Barbara ◽  
Tanya Melillo ◽  
Ronza Hadad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymphogranuloma Venereum ◽  
Factors Associated ◽  
Sex Parties ◽  
Sex With Men ◽  
Group Sex

From 1 January to 30 June 2018, 11 cases of Lymphogranuloma venereum (LGV; all preserved samples (n = 4) genovar L2b) were identified at the Genitourinary Clinic (GUC), Mater Dei Hospital, Msida, Malta. All cases were diagnosed in men who have sex with men (MSM); six participated in three group-sex parties. Here, we describe the outbreak and risk factors associated with LGV diagnoses in MSM in Malta in 2018.

scholarly journals Analysis of 721 Chlamydia trachomatis-positive urogenital specimens from men and women using LGV L2-specific real-time PCR assay

2006 ◽  
Vol 11 (42) ◽  
Author(s):  
D Goldenberger ◽  
F Dutly ◽  
M Gebhardt
Keyword(s):  
Chlamydia Trachomatis ◽  
Real Time ◽  
Real Time Pcr ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Pcr Assay ◽  
Men And Women ◽  
The World ◽  
Sex With Men

The epidemic of rectal lymphogranuloma venereum among men who have sex with men in western Europe and other parts of the world is ongoing

scholarly journals Lymphogranuloma Venereum in Australia: Anorectal Chlamydia trachomatis Serovar L2b in Men Who Have Sex with Men

2007 ◽  
Vol 45 (3) ◽  
pp. 1029-1031 ◽  
Author(s):  
D. Stark ◽  
S. van Hal ◽  
R. Hillman ◽  
J. Harkness ◽  
D. Marriott
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

scholarly journals P511 Surveillance of Lymphogranuloma venereum among men who have sex with men attending STI clinics in alberta, canada, 2018

2019 ◽  
Author(s):  
Jennifer Gratrix ◽  
John Niruban ◽  
Alberto Severini ◽  
Jennifer Beirnes ◽  
Prenilla Naidu ◽  
...  
Keyword(s):  
Lymphogranuloma Venereum ◽  
Sex With Men

Lymphogranuloma venereum genovariants in men having sex with men in Italy

2020 ◽  
pp. sextrans-2020-054700
Author(s):  
Antonella Marangoni ◽  
Claudio Foschi ◽  
Federico Tartari ◽  
Valeria Gaspari ◽  
Maria Carla Re
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
High Burden ◽  
Total Prevalence ◽  
Sex With Men ◽  
Reference Strains ◽  
Over Time

ObjectivesLymphogranuloma venereum (LGV) is an STI caused by Chlamydia trachomatis serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy.MethodsFrom 2016 to 2020, all the anorectal swabs collected from MSM attending the STI Clinic of St. Orsola-Malpighi Hospital in Bologna and positive for C. trachomatis were stored. LGV infection was confirmed by a pmpH PCR, and, subsequently, a fragment of the ompA gene was amplified and sequenced. Sequences were aligned to reference strains representing different LGV variants.ResultsLGV cases accounted for one-third of all chlamydial rectal infections with a total prevalence of 4.1% (76/1852). Total number of LGV cases per year remained constant. LGV was mainly found in symptomatic patients (>65%), older than 30 years, with a high burden of other STIs (63.7% HIV-positive, 35.5% with concurrent rectal gonorrhoea, 19.7% with early syphilis). A decreasing trend in HIV-LGV co-infection was noticed over time. Three main LGV genovariants were detected (L2f, 46.1%; L2b, 23.0%; L2-L2b/D-Da, 16.9%), together with other known L2b variants (mainly L2bV2 and L2bV4). Two novel L2b ompA variants with non-synonymous single-nucleotide polymorphisms were found. Over time, the percentage of L2f cases dropped gradually, with a significant increase in L2-L2b/D-Da cases (p=0.04).ConclusionsIn our area, LGV is endemic among MSM with different circulating genovariants. Active surveillance and genotyping programmes are needed to reduce re-establishing of LGV infection.

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