Neuropsychological Outcome after Deep Brain Stimulation in the Ventral Capsule/Ventral Striatum for Highly Refractory Obsessive-Compulsive Disorder or Major Depression

2013 ◽  
Vol 91 (6) ◽  
pp. 374-378 ◽  
Author(s):  
Cynthia S. Kubu ◽  
Donald A. Malone ◽  
Gordon Chelune ◽  
Paul Malloy ◽  
Ali R. Rezai ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Neuropsychological Outcome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

scholarly journals Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder

2019 ◽  
Vol 9 (9) ◽  
pp. 220 ◽  
Author(s):  
Baldermann ◽  
Bohn ◽  
Hammes ◽  
Schüller ◽  
Visser-Vandewalle ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Brain Metabolism ◽  
Ventral Striatum ◽  
Small Sample ◽  
Global Changes ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

Recent approaches have suggested that deep brain stimulation (DBS) for obsessive-compulsive disorder relies on distributed networks rather than local brain modulation. However, there is insufficient data on how DBS affects brain metabolism both locally and globally. We enrolled three patients with treatment-refractory obsessive-compulsive disorder with ongoing DBS of the bilateral ventral capsule/ventral striatum. Patients underwent resting-state 18F-fluorodeoxyglucose and positron emission tomography in both stimulation ON and OFF conditions. All subjects showed relative hypometabolism in prefronto-basal ganglia-thalamic networks compared to a healthy control cohort when stimulation was switched OFF. Switching the stimulation ON resulted in differential changes in brain metabolism. Locally, volumes of activated tissue at stimulation sites (n = 6) showed a significant increase in metabolism during DBS ON compared to DBS OFF (Mean difference 4.5 % ± SD 2.8; p = 0.012). Globally, differential changes were observed across patients encompassing prefrontal increase in metabolism in ON vs. OFF condition. Bearing in mind limitations of the small sample size, we conclude that DBS of the ventral capsule/ventral striatum for obsessive-compulsive disorder increases brain metabolism locally. Across distributed global networks, DBS appears to exert differential effects, possibly depending on localization of stimulation sites and response to the intervention.

Characterizing Effects of Ventral Striatum Deep Brain Stimulation in Obsessive-Compulsive Disorder With Resting Magnetoencephalography

2021 ◽  
Vol 89 (9) ◽  
pp. S287-S288
Author(s):  
Nithya Ramakrishnan ◽  
Jay R. Gavvala ◽  
Gregory S. Vogt ◽  
Michelle Avendano-Ortega ◽  
Nicole R. Provenza ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain
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