scholarly journals Comment on the Study ‘Long-Term Efficacy of Stereotactic Bilateral Anterior Cingulotomy and Bilateral Anterior Capsulotomy as a Treatment for Refractory Obsessive-Compulsive Disorder' by Zhang et al.

2013 ◽  
Vol 91 (4) ◽  
pp. 264-264 ◽  
Author(s):  
G. Rees Cosgrove
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Term Efficacy ◽  
Anterior Capsulotomy

Bilateral stereotactic anterior capsulotomy for obsessive-compulsive disorder: long-term follow-up

2013 ◽  
Vol 84 (11) ◽  
pp. 1208-1213 ◽  
Author(s):  
Myreille D'Astous ◽  
Sylvine Cottin ◽  
Martin Roy ◽  
Claude Picard ◽  
Léo Cantin
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Follow Up ◽  
Anterior Capsulotomy

Long-term efficacy of Internet-based cognitive behavior therapy for obsessive–compulsive disorder with or without booster: a randomized controlled trial

2014 ◽  
Vol 44 (13) ◽  
pp. 2877-2887 ◽  
Author(s):  
E. Andersson ◽  
S. Steneby ◽  
K. Karlsson ◽  
B. Ljótsson ◽  
E. Hedman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Behavior Therapy ◽  
Cognitive Behavior Therapy ◽  
Cognitive Behavior ◽  
Long Term Effects ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Term Efficacy

BackgroundAs relapse after completed cognitive behavior therapy (CBT) for obsessive–compulsive disorder (OCD) is common, many treatment protocols include booster programs to improve the long-term effects. However, the effects of booster programs are not well studied. In this study, we investigated the long-term efficacy of Internet-based CBT (ICBT) with therapist support for OCD with or without an Internet-based booster program.MethodA total of 101 participants were included in the long-term follow-up analysis of ICBT. Of these, 93 were randomized to a booster program or no booster program. Outcome assessments were collected at 4, 7, 12 and 24 months after receiving ICBT.ResultsThe entire sample had sustained long-term effects from pre-treatment to all follow-up assessments, with large within-group effect sizes (Cohen's d = 1.58–2.09). The booster group had a significant mean reduction in OCD symptoms compared to the control condition from booster baseline (4 months) to 7 months, but not at 12 or 24 months. Participants in the booster group improved significantly in terms of general functioning at 7, 12 and 24 months, and had fewer relapses. Kaplan–Meier analysis also indicated a significantly slower relapse rate in the booster group.ConclusionsThe results suggest that ICBT has sustained long-term effects and that adding an Internet-based booster program can further improve long-term outcome and prevent relapse for some OCD patients.

Tractography-Guided Anterior Capsulotomy for Major Depression and Obsessive-Compulsive Disorder: Targeting the Emotion Network

2021 ◽  
Author(s):  
Josue M Avecillas-Chasin ◽  
Trevor A Hurwitz ◽  
Nicholas M Bogod ◽  
Christopher R Honey
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Internal Capsule ◽  
Treatment Resistant ◽  
High Definition ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Anterior Capsulotomy ◽  
Term Benefit

Abstract BACKGROUND Bilateral anterior capsulotomy (BAC) is an effective surgical option for patients with treatment-resistant major depression (TRMD) and treatment-resistant obsessive-compulsive disorder (TROCD). The size of the lesion and its precise dorsal-ventral location within the anterior limb of the internal capsule (ALIC) remain undefined. OBJECTIVE To present a method to identify the trajectories of the associative and limbic white matter pathways within the ALIC for targeting in BAC surgery. METHODS Using high-definition tractography, we prospectively tested the feasibility of this method in 2 patients with TRMD and TROCD to tailor the capsulotomy lesion to their limbic pathway. RESULTS The trajectories of the associative and limbic pathways were identified in the ALIC of both patients and we targeted the limbic pathways by defining the dorsal limit of the lesion in a way to minimize the damage to the associative pathways. The final lesions were smaller than those that have been previously published. This individualized procedure was associated with long-term benefit in both patients. CONCLUSION Tractography-guided capsulotomy is feasible and was associated with long-term benefit in patients with TRMD and TROCD.

Unilateral right anterior capsulotomy for refractory major depression with comorbid obsessive–compulsive disorder

Neurocase ◽  
2011 ◽  
Vol 17 (6) ◽  
pp. 491-500 ◽  
Author(s):  
Alonso R. Riestra ◽  
Jaime Aguilar ◽  
Gerardo Zambito ◽  
Gabriela Galindo y Villa ◽  
Fernando Barrios ◽  
...  
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Anterior Capsulotomy

Augmentation strategy with olanzapine in resistant obsessive compulsive disorder: an Italian long-term open-label study

2005 ◽  
Vol 19 (4) ◽  
pp. 392-394 ◽  
Author(s):  
Donatella Marazziti ◽  
Chiara Pfanner ◽  
Bernardo Dell’osso ◽  
Antonio Ciapparelli ◽  
Silvio Presta ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Compulsive Disorder ◽  
Augmentation Strategy
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