The Beneficial Impact of Fasudil and Sildenafil on Monocrotaline-Induced Pulmonary Hypertension in Rats: A Hemodynamic and Biochemical Study

Pharmacology ◽  
2013 ◽  
Vol 91 (3-4) ◽  
pp. 178-184 ◽  
Author(s):  
Magdalena Jasinska-Stroschein ◽  
Jacek Owczarek ◽  
Anna Lucza ◽  
Daria Orszulak-Michalak
Keyword(s):  
Pulmonary Hypertension ◽  
Biochemical Study ◽  
Beneficial Impact

scholarly journals The changing landscape of chronic thromboembolic pulmonary hypertension management

2017 ◽  
Vol 26 (146) ◽  
pp. 170105 ◽  
Author(s):  
Michael Madani ◽  
Takeshi Ogo ◽  
Gérald Simonneau
Keyword(s):  
Pulmonary Hypertension ◽  
Treatment Options ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Standard Of Care ◽  
Surgical Removal ◽  
Pulmonary Endarterectomy ◽  
Current Standard ◽  
Beneficial Impact ◽  
Background Therapy ◽  
Thromboembolic Pulmonary Hypertension

For patients with chronic thromboembolic pulmonary hypertension (CTEPH), the current standard of care involves surgical removal of fibro-thrombotic obstructions by pulmonary endarterectomy. While this approach has excellent outcomes, significant proportions of patients are not eligible for surgery or suffer from persistent/recurrent pulmonary hypertension after the procedure. The availability of balloon pulmonary angioplasty and the approval of the first medical therapy for use in CTEPH have significantly improved the outlook for patients ineligible for pulmonary endarterectomy. In this comprehensive review, we discuss the latest developments in the rapidly evolving field of CTEPH. These include improvements in imaging modalities and advances in surgical and interventional techniques, which have broadened the range of patients who may benefit from such procedures. The efficacy and safety of targeted medical therapies in CTEPH patients are also discussed, particularly the encouraging data from the recent MERIT-1 trial, which demonstrated the beneficial impact of using macitentan to treat patients with inoperable CTEPH, including those on background therapy. As the treatment options for CTEPH improve, hybrid management involving more than one intervention in the same patient may become a viable option in the near future.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

Porto-pulmonary hypertension in decompensated cirrhosis and refractory ascites

2001 ◽  
Vol 120 (5) ◽  
pp. A377-A377
Author(s):  
F BENJAMINOV ◽  
K SNIDERMAN ◽  
S SIU ◽  
P LIU ◽  
M PRENTICE ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Refractory Ascites ◽  
Decompensated Cirrhosis

Biochemical Study of the Large Molecular Constituents of Gastric Juice

1955 ◽  
Vol 29 (6) ◽  
pp. 1017-1023 ◽  
Author(s):  
Virginia Richmond ◽  
Ranwel Caputto ◽  
Stewart Wolf
Keyword(s):  
Gastric Juice ◽  
Biochemical Study

725 Immunomodulatory effects of thymulin in monocrotalin-induced pulmonary hypertension

2006 ◽  
Vol 5 (1) ◽  
pp. 168-169
Author(s):  
S OLIVEIRA ◽  
T HENRIQUESCOELHO ◽  
F LAFUENTECARVALHO ◽  
A BRANDAONOGUEIRA ◽  
M SANTOS ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Immunomodulatory Effects
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