Non-Natriuretic Doses of Furosemide: Potential Use for Decreasing the Workload of the Renal Outer Medulla with Minimal Magnesium Wasting in the Rat

2012 ◽  
Vol 122 (1-2) ◽  
pp. 7-12 ◽  
Author(s):  
Namhee Kim ◽  
Surinder Cheema-Dhadli ◽  
Gregory M.T. Hare ◽  
Chee Kiong Chong ◽  
Mitchell L. Halperin ◽  
...  
Keyword(s):  
Outer Medulla ◽  
Potential Use ◽  
Renal Outer Medulla

Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II

2003 ◽  
Vol 284 (5) ◽  
pp. R1219-R1230 ◽  
Author(s):  
Baozhi Yuan ◽  
Mingyu Liang ◽  
Zhizhang Yang ◽  
Elizabeth Rute ◽  
Norman Taylor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Western Blot ◽  
Renal Injury ◽  
Interstitial Fibrosis ◽  
Control Period ◽  
Renal Medulla ◽  
Differentially Expressed ◽  
Ang Ii ◽  
Outer Medulla ◽  
Renal Outer Medulla

The present study was designed to determine whether nonhypertensive elevations of plasma ANG II would modify the expression of genes involved in renal injury that could influence oxidative stress and extracellular matrix formation in the renal medulla using microarray, Northern, and Western blot techniques. Sprague-Dawley rats were infused intravenously with either ANG II (5 ng · kg−1 · min−1) or vehicle for 7 days ( n = 6/group). Mean arterial pressure averaged 110 ± 0.6 mmHg during the control period and 113 ± 0.4 mmHg after ANG II. The mRNA of 1,751 genes (∼80% of all currently known rat genes) that was differentially expressed (ANG II vs. saline) in renal outer and inner medulla was determined. The results of 12 hybridizations indicated that in response to ANG II, 11 genes were upregulated and 25 were downregulated in the outer medulla, while 11 were upregulated and 13 were downregulated in the inner medulla. These differentially expressed genes, most of which were not known previously to be affected by ANG II in the renal medulla, were found to group into eight physiological pathways known to influence renal injury and kidney function. Particularly, expression of several genes would be expected to increase oxidative stress and interstitial fibrosis in the outer medulla. Western blot analyses confirmed increased expression of transforming growth factor-β1 and collagen type IV proteins in the outer medulla. Results demonstrate that nonhypertensive elevations of plasma ANG II can significantly alter the expression of a variety of genes in the renal outer medulla and suggested the vulnerability of the renal outer medulla to the injurious effect of ANG II.

scholarly journals Ureteral obstruction decreases ATP dependent H+-pump activity of rabbit renal outer medulla.

1990 ◽  
Vol 160 (3) ◽  
pp. 223-229
Author(s):  
HIROYOSHI KANEMITSU ◽  
SET SASAKI ◽  
TAKASHI AKIBA ◽  
FUMIAKI MARUMO
Keyword(s):  
Ureteral Obstruction ◽  
Outer Medulla ◽  
Pump Activity ◽  
Renal Outer Medulla

scholarly journals Stimulatory effect of guanine nucleotides on prostaglandin E1 binding to murine renal outer medulla.

1991 ◽  
Vol 14 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Kazuhiro KIMURA ◽  
Nobuko FUJIWARA ◽  
Manabu NEGISHI ◽  
Kimio YATSUNAMI ◽  
Atsushi ICHIKAWA
Keyword(s):  
Prostaglandin E1 ◽  
Guanine Nucleotides ◽  
Outer Medulla ◽  
Renal Outer Medulla

Metabolism of lactate and pyruvate in dog renal outer medulla

1979 ◽  
Vol 10 (9) ◽  
pp. xxiv-xxv
Author(s):  
G. Baverel ◽  
M. Forissier ◽  
M. Pellet ◽  
G. Baverel
Keyword(s):  
Outer Medulla ◽  
Lactate And Pyruvate ◽  
Renal Outer Medulla
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