Serum Ferritin and Vitamin D in Female Hair Loss: Do They Play a Role?

2013 ◽  
Vol 26 (2) ◽  
pp. 101-107 ◽  
Author(s):  
H. Rasheed ◽  
D. Mahgoub ◽  
R. Hegazy ◽  
M. El-Komy ◽  
R. Abdel Hay ◽  
...  
Keyword(s):  
Author(s):  
Amal O. Al balbeesi

<p class="abstract"><strong>Background:</strong> Female pattern hair loss is a problematic condition. The availability of a rapid indicator is crucial. The current study compared female pattern hair loss patients with healthy controls regarding hematological parameters and vitamin D levels.</p><p class="abstract"><strong>Methods:</strong> We included 78 females with female pattern hair loss and 50 healthy subjects in the control group. We collected a detailed medical history and performed a systematic clinical examination. Blood samples were collected including complete blood count, serum ferritin, and vitamin D.<strong></strong></p><p class="abstract"><strong>Results:</strong> A significant increase in positive family history and acne among the study than the control group. Most patients had mild disease (55.1%). Female pattern hair loss was significantly associated with a reduction in red blood cell count, hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, red cell distribution width, serum ferritin and serum vitamin D. Among the patient’s group, the disease severity was positively correlated with disease duration and patient age. The correlation with duration was moderate (r=0.366). The disease duration was positively correlated with body mass index and negatively correlated with red blood cell count, hemoglobin concentration, hematocrit, red cell indices, ferritin and vitamin D. Disease duration was also inversely correlated with vitamin D levels.</p><p class="abstract"><strong>Conclusions:</strong> Family history, body mass index, acne, hirsutism and irregular period were high among Saudi women. The disease was moderately severe. FPHL was associated with a significant reduction in hematological parameters and lower serum ferritin that indicated iron deficiency could play a crucial role in the development or progression of the disease. As a preventable etiology, restoring iron stores may provide at least an adjunct therapeutic option.</p>


Author(s):  
V. A. Belgaumkar ◽  
R. B. Chavan ◽  
N. S. Deshmukh ◽  
P. Patil ◽  
N. Bhatt ◽  
...  

<p class="abstract"><strong>Background: </strong>Diffuse hair loss is a common complaint encountered by dermatologists in clinical practice and can be alarming to the patients. Chronic telogen effluvium (CTE) is characterized by an abrupt onset of diffuse loss of scalp hair persisting for more than six months, predominantly affecting healthy women in their fourth to fifth decade of life. Although CTE is considered to be associated with various nutritional deficiencies, currently the evidence to substantiate this assertion is conflicting.</p><p class="abstract"><strong>Methods: </strong>A cross-sectional study was conducted on 100 adult non-pregnant women with CTE to document serum ferritin, B12 and vitamin D levels in an attempt to validate their role as biochemical markers using Statistical package for social sciences (SPSS) version 25:0 and Fisher’s exact test.</p><p class="abstract"><strong>Results:</strong> Mean ferritin level was 31.17 ng/dL. 23% patients had serum ferritin levels lower than the normal range (13-150 ng/dL). Vitamin D levels (normal range 5.2-60.4 ng/ml, mean 21.41 ng/ml) were low (deficiency range) in 2%. Vitamin B12 levels (normal range 191-663 pg/ml, mean 239.79) were low in 35.7% patients. Other parameters like duration, family history, past history of treatment did not demonstrate any statistically significant correlation.</p><p class="abstract"><strong>Conclusions: </strong>Our study detected low levels of serum ferritin and vitamin B12 in approximately one-fourth and a third of females with chronic telogen effluvium respectively with vitamin D deficiency found in only a small proportion. Although a statistically significant correlation could not be established between these nutrients and participant age or other parameters; we concur with most authors who recommend that all females with diffuse hair loss deserve a thorough screening for nutritional deficiencies to facilitate prompt recognition and timely supplementation.</p>


2021 ◽  
Vol 8 (3) ◽  
pp. 1-8
Author(s):  
Samar Tahlawy ◽  
Mohammed Alkhayat ◽  
Hassan Ali ◽  
Eman Samhoud

Author(s):  
Kriteeka Saini ◽  
Venkataram Mysore
Keyword(s):  

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Nan-Hee Kang ◽  
Ha-Neul Choi ◽  
Jung-Eun Yim

AbstractIntroductionIn Korean women, the prevalence rate of severe obesity (BMI ≥ 30.0 kg/m2) increased from 2.8% in 2005 to 4.7% in 2015. It is reported that clinically severe obesity has more serious health problems than moderate obesity and creates additional challenges. Vitamin D was suggested a beneficial effect on inflammatory response, but serum ferritin was has been known as a biomarker of inflammation. The objective of this study is to compare the levels of vitamin D and ferritin in Korean women with moderate and severe obesity.Materials and Methods44 Korean women with obese and severely obese were recruited. The participants were classified as obese (BMI 25.0–29.9 kg/m2, n = 23) and severely obese (BMI ≥ 30.0 kg/m2, n = 21) group. The informed clinical data, including general information, anthropometric data, body composition, and blood analysis results, were obtained from the participants. Serum vitamin D [25(OH)D3] and ferritin were measured. Statistical analyses were performed using the SPSS Statistics for Windows version 24.0.ResultsThere was a difference in eating habits, severely obese group ate more irregularly and consumed more snacks than obese group. The levels of alanine aminotransferase, aspartate aminotransferase, hemoglobin Alc, total cholesterol, and triglyceride were not significantly different in obese and severely obese group. And, the levels of serum 25(OH)D3 and ferritin were almost normal and there was no significant difference between the two groups.ConclusionThis study showed that there is a difference in eating habits between obese group and severely obese group. The level of serum 25(OH)D3 was not declined while the level of serum ferritin was not elevated in Korean obese and severely obese women. This study has been performed with the limitation that the number of samples was not enough.


2017 ◽  
Vol 49 (5S) ◽  
pp. 713
Author(s):  
Brigid Byrd ◽  
Jeffrey Martin ◽  
Kristin Landis-Piwowar ◽  
Carrie Aprik ◽  
Tamara Hew-Butler

2014 ◽  
Vol 133 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Basavraj Sooragonda ◽  
Sanjay Kumar Bhadada ◽  
Viral N. Shah ◽  
Pankaj Malhotra ◽  
Jasmina Ahluwalia ◽  
...  

Background: The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. Methods: We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum ferritin <15 µg/l) were randomized to an intervention arm (cholecalciferol, i.e. vitamin D3, 0.6 million units i.m. once) or placebo. In all subjects, iron deficiency was corrected with parental iron. Other causes of anemia were excluded with appropriate investigation. The primary end point was a rise in Hb concentration. Results: Baseline parameters of age, BMI, hemogram values and levels of serum ferritin, 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) were similar in the 2 arms. Twelve weeks after vitamin D replacement, there was a significant increase in 25 (OH)D levels (57.7 ± 20.5 vs. 14.1 ± 6.2 ng/ml, p < 0.0001) and a decrease in PTH levels (32.4 ± 16.4 vs. 52.9 ± 18.4 pg/ml, p = 0.003) in subjects in the intervention arm when compared to the placebo arm. However, the increments in serum ferritin and Hb concentration in the intervention and placebo arm did not differ. Conclusion: Vitamin D replacement in subjects with iron-deficiency anemia after iron correction does not improve Hb concentration further.


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 674-674
Author(s):  
Ximena Palma Molina ◽  
Julia Finkelstein ◽  
Saurabh Mehta ◽  
Teresa Shamah-Levy ◽  
Juan RIvera-Dommarco ◽  
...  

Abstract Objectives To examine the associations between micronutrient status and child growth, as part of the National Health and Nutrition Survey in Mexico. Methods Data from the National Health and Nutrition Survey (ENSANUT 2018) were analyzed to examine the association between micronutrient status and child growth in 1,656 children 36 to 59 months of age. Micronutrient biomarkers (serum ferritin (SF), vitamin B12, vitamin D, serum zinc) were measured in venous blood samples via immunoassays. Child weight and height were measured using standardized procedures, and indicators weight-for-age (WAZ), height-for-age (HAZ), weight-for-height (WHZ), and body mass index (BMI) Z-scores were calculated using the WHO Anthro V3.1 and categorized as per WHO Child Growth Standards. Micronutrient biomarkers were natural logarithmically transformed prior to analyses. Iron deficiency was defined as SF &lt; 12.0 μg/L and iron insufficiency was defined as SF &lt; 20.0 μg/L. Vitamin B12 deficiency and insufficiency were defined as &lt; 148 and &lt; 221 pmol/L, respectively. Vitamin D deficiency was defined as &lt; 50 nmol/L, and zinc deficiency was defined as &lt; 65μg/dL. Survey linear regression models were used to examine associations of micronutrient status with WHO Z-scores. Results Serum ferritin concentrations (β [SE]: 0.096 [0.001], p &lt; 0.0001) and vitamin B12 (0.092 [0.003], p &lt; 0.0001) concentrations were associated with higher WHZ. Vitamin B12 (0.171 [0.004], p &lt; 0.0001), vitamin D (0.358 [0.007], p &lt; 0.0001), and zinc (0.122 [0.006], p &lt; 0.0001) concentrations were associated with higher HAZ. Iron deficiency (β [SE]: -0.469 [0.004], p &lt; 0.0001) and zinc deficiency (-0.203 [0.01], p &lt; 0.0001) were associated with lower WHZ, and vitamin B12 (-0.449 [0.002], p &lt; 0.0001), vitamin D (-0.215 [0.001], p &lt; 0.0001) and zinc (-0.216 [0.01], p &lt; 0.0001) deficiencies were associated with lower HAZ. Conclusions Micronutrient deficiencies of vitamin B12, vitamin D, and zinc were associated with lower linear growth in young children in Mexico. Funding Sources ENSANUT was funded by The Ministry of Health of Mexico.


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