Gut-Brain Communication in the Regulation of System Metabolism

2013 ◽  
pp. 96-102
Author(s):  
Timo D. Müller ◽  
Paul T. Pfluger ◽  
Matthias H. Tschöp
Keyword(s):  
System Metabolism

Effect of Sleep Loss on Pain

2020 ◽  
pp. 556-608
Author(s):  
Chloe Alexandre ◽  
Alban Latremoliere ◽  
Patrick H. Finan
Keyword(s):  
Cognitive Processing ◽  
Sleep Disturbances ◽  
Inhibitory Pathways ◽  
Inflammatory Processes ◽  
Lack Of Sleep ◽  
Significant Extension ◽  
Neurological Processes ◽  
Dynamic Components ◽  
The Cost ◽  
System Metabolism

With the advent of modern lifestyles, there has been a significant extension of daily activities, mostly at the cost of sleep. Lack of sleep affects many biological systems, including various cognitive functions, the immune system, metabolism, and pain. Both sleep and pain are complex neurological processes that encompass many dynamic components. As a result, defining the precise interactions between these two systems represents a challenge, especially for chronic paradigms. This chapter describes how sleep is measured and how it can be experimentally altered in humans and animal models, and, in turn, how sleep disturbances, either acute or chronic, can affect different aspects of pain. Possible mechanisms involved are discussed, including an increase in inflammatory processes, a loss of nociceptive inhibitory pathways, and a defect in the cognitive processing of noxious inputs.

A model-based approach to measuring denitrification and greenhouse gas production in lakes

2021 ◽  
Author(s):  
Juliet Falco Ajambo-Doherty
Keyword(s):  
Greenhouse Gas ◽  
Atmospheric Pressure ◽  
Schmidt Number ◽  
Spatial Scales ◽  
Gas Production ◽  
System Model ◽  
Biogeochemical Processes ◽  
Model Based ◽  
Temporal And Spatial ◽  
System Metabolism

An existing whole-system model based on changes in dissolved N₂ concentration was modified for lentic systems. Field validations carried out at Christie Lake in Dundas, ON and Turtle Pond in Stoney Creek, ON (Canada). New model inputs included air temperature, atmospheric pressure, relative humidity, wind velocity, and Schmidt number. Mont Carlo analysis was integrated into the model to better constrain error in model estimates of denitrification, whole-system metabolism, and greenhouse gas production. Denitrification rates ranged from -419-4415 µmol N.m-².h-¹ in Christie Lake and from 10-74 µmol N.m-².h-¹ in Turtle Pond. N₂O production ranged from 915-10,635 nmol N.m-².h-¹ in Christie Lake and from -344-131 nmol N.m-².h-¹ in Turtle Pond. The whole-system model allows for the examination of biogeochemical processes at ecologically significant temporal and spatial scales.

scholarly journals Effects of Different Methionine Levels in Low Protein Diets on Production Performance, Reproductive System, Metabolism, and Gut Microbiota in Laying Hens

2021 ◽  
Vol 8 ◽  
Author(s):  
Miaolin Ma ◽  
Shunju Geng ◽  
Meiling Liu ◽  
Lihong Zhao ◽  
Jianyun Zhang ◽  
...  
Keyword(s):  
Reproductive System ◽  
Laying Hens ◽  
Production Performance ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Microbial Composition ◽  
Low Protein ◽  
System Metabolism ◽  
Protein Diets ◽  
Different Levels

This study investigated the effects of different levels of methionine (Met) in a low protein diet on the production performance, reproductive system, metabolism, and gut microbial composition of laying hens to reveal the underlying molecular mechanism of Met in a low protein diet on the host metabolism and gut microbial composition and function of hens. A total of 360 healthy 38-week-old Peking Pink laying hens with similar body conditions and egg production (EP) were randomly divided into four groups with nine replicates per treatment and 10 hens per replicate. The hens in each treatment group were fed low protein diets containing different levels of Met (0.25, 0.31, 0.38, and 0.47%, respectively) for 12 weeks. Feed and water were provided ad libitum throughout the trial period. The results showed that, compared with the 0.25% Met group, the final body weight (FBW), average daily gain (ADG), EP, egg weight (EW), and average daily feed intake (ADFI) in the other groups were significantly increased and feed egg ratio (FER) was decreased. Meanwhile, the EW and yield of abdominal fat (AFY) in the 0.47% Met group were higher than those in other groups. The triglyceride (TG), estradiol (E2), total protein (TP), albumin (ALB), and immunoglobulin A (IgA) in the 0.38 and 0.47% Met groups were higher than those in other groups. In addition, 16S rRNA gene sequencing revealed that there was no difference in the Sobs index, ACE index, and Shannon index among all groups. However, it is worth noting that feeding low protein diets with Met changed the gut microbial composition (e.g., the supplementation of Met increased the level of Lactobacillus and decreased the proportion of Faecalibacterium). Also, our results showed that the changes in gut microbial composition induced by the diets with different levels of Met were closely related to the changes of key parameters: ADFI, EW, FBW, TG, EM, EP, ADG, FER, and uric acid (UA). Our results highlight the role of adding an appropriate amount of Met to the low protein diet in laying hens, which could improve the gut microbial composition, production performance, reproductive system, and nutrient metabolism of laying hens. In conclusion, this study suggested that when the Met level was 0.38%, the production performance of the laying hens was pretty good.

scholarly journals Bioactive Cembranoid Composition in the Soft Coral of Sarcophyton glaccum on The Response to Changing pH

2017 ◽  
Vol 22 (1) ◽  
pp. 25
Author(s):  
Hedi Indra Januar ◽  
Neviaty Putri Zamani ◽  
Dedi Soedharma ◽  
Ekowati Chasanah
Keyword(s):  
Ocean Acidification ◽  
Soft Coral ◽  
Resonance Spectroscopy ◽  
Moderate Increase ◽  
Tumor Cell Lines ◽  
Defense System ◽  
Seawater Acidification ◽  
Quantitative Nuclear Magnetic Resonance ◽  
Acidic Conditions ◽  
System Metabolism

Soft coral is predicted to outcompete with hard coral in future ocean acidification scenarios. Beside the biological resilience shown in acidic conditions, soft corals ability to maintain or compete for space is shown to relate with their ability to produce cytotoxic cembranoid-type compounds. The aim of this study was to investigate composition of cytotoxic cembranoid compounds of Sarcophyton glaccum soft coral exposed to current and predicted future ocean acidification scenarios. Sarcophyton glaccum colonies were acclimated along a pH gradient to simulate predicted increases in ocean acidification: natural/current (pH 8,2), slight increase in acidification (pH 8.0 year-1 2060), and moderate increase in acidification (pH 7,8 year­-1 2100). Cembranoid composition was determined by quantitative Nuclear Magnetic Resonance spectroscopy while cytotoxic activity was determined against tumor cell lines. Results of the study showed cytotoxicity and sarcophytoxide (the most active cembranoid compound in observed Sarcophyton glaccum) were both found to be higher at pH 8,0. However, a further increase of acidification resulted on a reduction of both the cytotoxicity and sarcophytoxide production. This suggests that acidification pressures affect directly the defense system metabolism of Sarcophyton glaccum and that while they may be resilient to small decreases in pH, their ability to compete for space may be hampered by more pronounced changes. Keywords: Cembranoids; Cytotoxic; Sarcophyton glaccum; Seawater Acidification; Soft Coral.

Organic and inorganic whole system metabolism in two acidified coastal systems in Ireland

2020 ◽  
Author(s):  
Maria Teresa Guerra ◽  
Carlos Rocha
Keyword(s):  
Ocean Acidification ◽  
Dissolved Inorganic Carbon ◽  
Total Alkalinity ◽  
Carbonate System ◽  
Net Community Production ◽  
Coastal Acidification ◽  
Autumn And Winter ◽  
System Metabolism ◽  
Internal Buffer ◽  
Community Production

<p>Organic and inorganic whole system metabolism for two Irish coastal areas were compared to evaluate carbonate system resilience to acidification. The two systems are characterized by contrasting watershed input types and composition. Kinvara Bay is fed by Submarine Groundwater Discharge (SGD) derived from a karstic catchment while Killary Harbour is fed by river discharge draining a siliciclastic catchment. Freshwater sources to sea have distinct Total Alkalinity (TA) and Dissolved Inorganic Carbon (DIC) concentrations, higher and lower than the open ocean, respectively, but both evidence seasonally variable low pH, ranging from 6.20 to 7.50. Retention of TA and DIC was calculated for the two areas using LOICZ methodology. In Kinvara bay, annually averaged retention of DIC was greater than for TA (5 × 10<sup>4</sup> and 1.5 × 10<sup>5</sup> mol d<sup>-1</sup>), suggesting the system is acidifying further. Conversely, Killary Harbour shows negative TA and DIC retention, with DIC:TA <1, suggesting an internal buffer against ocean acidification is operating.</p><p>Net Community Production (NCP) was calculated for both systems using Dissolved Oxygen data. Subsequently, we estimated Net Community Calcification (NCC) from the ratio between TA and DIC. NCP was always positive in Killary Harbour with an average of 318 mmol O<sub>2</sub> m<sup>-2 </sup>d<sup>-1</sup> (equivalent to 89 mol C m<sup>-2</sup> y<sup>-1</sup>). However, Kinvara Bay shows relatively lower positive NCP in spring and summer (average of 46 mmol O<sub>2</sub> m<sup>-2</sup> d<sup>-1</sup>), but negative NCP in autumn and winter. Therefore, Kinvara Bay’s Total Organic Carbon (TOC) production was low, at ~21 g m<sup>-2</sup> y<sup>-1</sup> and not enough to overcome acidification driven by the SGD source composition. These results emphasize the complexity of interactions between the drivers of coastal acidification rate, affecting our ability to accurately assess the resilience of the carbonate system in these areas to ocean acidification pressure in the future.</p>

The relationship between testosterone deficiency and frailty in elderly men

2010 ◽  
Vol 4 (1) ◽  
Author(s):  
Farid Saad
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Adverse Outcomes ◽  
Mineral Density ◽  
Elderly Men ◽  
Clinical Investigations ◽  
Younger Men ◽  
System Metabolism

AbstractThe vulnerable health status usually preceding the onset of overt disability is often referred to as frailty. A stringent definition is elusive but it can be viewed as a physiological syndrome, characterized by decreased reserve and diminished resistance to stressors, resulting from a cumulative decline across multiple physiological systems and causing vulnerability to adverse outcomes. Elements of frailty are related to the neurological system, metabolism, joints, bones, and muscles. Sarcopenia seems to be the major determinant of frailty. Several components of the frailty syndrome are related to loss of physiological actions of testosterone (T). T and/or its aromatized metabolite, estradiol, are necessary for maintenance of bone mineral density. Furthermore, T stimulates erythrocyte formation. T has a profound effect on body composition. Androgens promote differentiation of mesenchymal pluripotent cells into the myogenic lineage and inhibit differentiation into the adipogenic lineage. Skeletal muscles of older men are as responsive to the anabolic effects of T as of younger men. Thus, although frailty is obviously a complex syndrome, some elements are androgen-associated and these can improve in men with subnormal T levels when treated with T. Evidence suggests that T treatment in frail elderly men with low T improves body composition, quality of life, and physical function, including increased axial bone mineral density and body composition. The data available to date strongly suggest a relationship between T-deficiency and frailty and warrant further basic and clinical investigations to extend these observations to the management of elderly men with frailty.

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