Less Invasive Surfactant Administration in Extremely Preterm Infants: Impact on Mortality and Morbidity

Neonatology ◽  
2013 ◽  
Vol 103 (4) ◽  
pp. 252-258 ◽  
Author(s):  
Katrin Klebermass-Schrehof ◽  
Martin Wald ◽  
Jens Schwindt ◽  
Agnes Grill ◽  
Andrea-Romana Prusa ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Mortality And Morbidity ◽  
Less Invasive ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Surfactant Administration

scholarly journals Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 420
Author(s):  
Claudia Ioana Borțea ◽  
Florina Stoica ◽  
Marioara Boia ◽  
Emil Radu Iacob ◽  
Mihai Dinu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Surfactant Administration ◽  
Stage 1

Background and Objectives: Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm infants. We studied the relationship between different perinatal characteristics, i.e., sex; gestational age (GA); birth weight (BW); C-reactive protein (CRP) and lactate dehydrogenase (LDH) concentrations; ventilation, continuous positive airway pressure (CPAP), and surfactant administration; and the incidence of Stage 1–3 ROP. Materials and Methods: This study included 247 preterm infants with gestational age (GA) < 32 weeks that were successfully screened for ROP. Univariate and multivariate binary analyses were performed to find the most significant risk factors for ROP (Stage 1–3), while multivariate multinomial analysis was used to find the most significant risk factors for specific ROP stages, i.e., Stage 1, 2, and 3. Results: The incidence of ROP (Stage 1–3) was 66.40% (164 infants), while that of Stage 1, 2, and 3 ROP was 15.38% (38 infants), 27.53% (68 infants), and 23.48% (58 infants), respectively. Following univariate analysis, multiple perinatal characteristics, i.e., GA; BW; and ventilation, CPAP, and surfactant administration, were found to be statistically significant risk factors for ROP (p < 0.001). However, in a multivariate model using the same characteristics, only BW and ventilation were significant ROP predictors (p < 0.001 and p < 0.05, respectively). Multivariate multinomial analysis revealed that BW was only significantly correlated with Stage 2 and 3 ROP (p < 0.05 and p < 0.001, respectively), while ventilation was only significantly correlated with Stage 2 ROP (p < 0.05). Conclusions: The results indicate that GA; BW; and the use of ventilation, CPAP, and surfactant were all significant risk factors for ROP (Stage 1–3), but only BW and ventilation were significantly correlated with ROP and specific stages of the disease, namely Stage 2 and 3 ROP and Stage 2 ROP, respectively, in multivariate models.

SNAP-II for prediction of mortality and morbidity in extremely preterm infants

2018 ◽  
Vol 32 (16) ◽  
pp. 2694-2701 ◽  
Author(s):  
Marc Beltempo ◽  
Prakesh S. Shah ◽  
Xiang Y. Ye ◽  
Jehier Afifi ◽  
Shoo Lee ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Mortality And Morbidity ◽  
Prediction Of Mortality ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

2018 ◽  
Vol 192 ◽  
pp. 53-59.e2 ◽  
Author(s):  
Abbot R. Laptook ◽  
Edward F. Bell ◽  
Seetha Shankaran ◽  
Nansi S. Boghossian ◽  
Myra H. Wyckoff ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Mortality And Morbidity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Samuel J. Gentle ◽  
Amelia Freeman ◽  
Rakesh P. Patel ◽  
Namasivayam Ambalavanan ◽  
Charitharth V. Lal
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Predictive Biomarkers ◽  
University Of Alabama ◽  
Common Complication ◽  
Mortality And Morbidity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
The University ◽  
Tracheal Aspirates

Abstract Rationale Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity and significantly contributes to mortality and morbidity with few predictive biomarkers. Given that nitrites have been implicated in pathways associated with lung disease, we hypothesized that nitrite levels would be altered in the airways of premature infants diagnosed with BPD. Methods This was a prospective cohort study of extremely low birth infants (< 28 weeks’ gestation) at the University of Alabama at Birmingham. Nitrite levels from tracheal aspirates (TAs) were compared between intubated and ventilated infants with BPD and gestation matched full term (FT) controls. TA derived nitrite levels from day one after birth were also compared between preterm infants who did and did not develop BPD. Results Infants with BPD were found to have significantly elevated nitrite levels in their tracheal aspirates compared to gestation matched FT controls (p < 0.05). There was a trend for increased nitrite levels on postnatal day one in infants that developed BPD compared to infants that did not develop BPD (p = 0.05). Conclusions In conclusion, nitrite levels are significantly increased in airways of infants with BPD. Data from a larger cohort are needed to further support the utility of nitrite for BPD prediction. Trial registration Not applicable.

scholarly journals Association of Gastric Residual Volumes With Necrotising Enterocolitis in Extremely Preterm Infants

2021 ◽  
Author(s):  
gajanan purohit ◽  
Mehkarkar Puja ◽  
Athalye-Jape Gayatri ◽  
Nathan Elizabeth ◽  
Patole Sanjay
Keyword(s):  
Birth Weight ◽  
Preterm Infants ◽  
Necrotising Enterocolitis ◽  
Stage Ii ◽  
Mortality And Morbidity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Significant Difference ◽  
Median Maximum ◽  
Control Study

Abstract Necrotising enterocolitis (NEC) is a potentially serious illness with significant mortality and morbidity in preterm infants. Previous studies have reported association of volume and colour (bile and blood stained) of gastric residuals (GR) with NEC. We aimed to study this association in our cohort of extremely preterm (EP) infants. In a case-control study using retrospective data (January 2006-December 2011), EP (Gestation <28 weeks) infants with confirmed NEC ≥ Stage II (Cases) were compared with infants without NEC (Controls) matched for birth weight (BW) and gestational age (GA). Forty cases of NEC ≥ Stage II diagnosed at a median (IQR) age of 16.5 (10.3-23) days were compared with 40 controls matched for gestation (±3 days), and birth weight (±680 g). Median maximum GR volume (GRV) from birth to the day of occurrence of NEC was significantly higher in cases vs. controls (5.9 vs.3.7 ml; p<0.001). Increased maximum GRV was associated with NEC ≥ Stage II in adjusted analysis (aOR 1.36, 95%CI 1.06-1.75, p=0.017). There was no significant difference in GRV between cases and controls throughout the clinical course, including 72, 48 and 24 hours before the onset of NEC. However, green (65.0% vs. 27.5%, p=0.001) and haemorrhagic GRs (45.0% vs. 27.5%, p=0.092) were higher 24 hours before the diagnosis of NEC.Conclusion: GRV was not associated with NEC ≥ Stage II. However, green and haemorrhagic GRs were significantly higher 24 hours before the diagnosis of the illness. Adequately powered prospective studies are needed to confirm the significance of our findings.

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