scholarly journals Late-Onset Neurodegeneration with Brain Iron Accumulation with Diffusion Tensor Magnetic Resonance Imaging

2012 ◽  
Vol 4 (3) ◽  
pp. 216-223 ◽  
Author(s):  
Syed Omar Shah ◽  
Hasit Mehta ◽  
Robert Fekete
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Late Onset ◽  
Iron Accumulation ◽  
Resonance Imaging ◽  
Brain Iron

scholarly journals Neurodegeneration with Brain Iron Accumulation in an Eleven-Year-Old Jamaican Male

2014 ◽  
Vol 2014 ◽  
pp. 1-2 ◽  
Author(s):  
Peter Johnson ◽  
Roxanne Melbourne-Chambers ◽  
Nilesh Desai ◽  
Emma Greenaway
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Inborn Error ◽  
Autosomal Recessive ◽  
Iron Accumulation ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Brain Iron ◽  
Extrapyramidal Signs ◽  
The Caribbean

We present a case of an eleven-year-old boy presenting with progressive extrapyramidal signs and dementia. His imaging findings demonstrated the classic eye-of-the-tiger sign on T2W magnetic resonance imaging. He was diagnosed with pantothenate kinase-associated neurodegeneration (PKAN). This is a rare autosomal recessive inborn error of coenzyme A metabolism, caused by mutations inPANK2. This is the first reported case of PKAN from the Caribbean.

Eye of the Tiger: Looking Beyond Neurodegeneration with Brain Iron Accumulation Disorders

2021 ◽  
Author(s):  
Prajnya Ranganath ◽  
Mallikarjun Patil
Keyword(s):  
Magnetic Resonance Imaging ◽  
Basal Ganglia ◽  
Magnetic Resonance ◽  
Neurodegenerative Disorders ◽  
Brain Magnetic Resonance Imaging ◽  
Iron Accumulation ◽  
Resonance Imaging ◽  
Brain Iron ◽  
Mri Brain ◽  
Magnetic Resonance Imaging Mri

AbstractThe “eye-of-the-tiger” sign in brain magnetic resonance imaging (MRI) is typically associated with neurodegeneration with brain iron accumulation disorders, especially pantothenate kinase-associated neurodegeneration. However, very similar neuroimaging findings may be seen in other neurodegenerative disorders involving the basal ganglia. We report here a patient with fucosidosis who had MRI brain findings closely resembling the “eye-of-the-tiger” sign.

scholarly journals Diffusion tensor magnetic resonance imaging of optic pathway in cases of suprasellar masses

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Nada Ashraf Abd El-Hady ◽  
Mohammad Mahmoud Alhousini Alashwah ◽  
Haitham Haroun Emam ◽  
Ashraf Mohamed Farid Rahil
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Optic Pathway ◽  
Resonance Imaging

scholarly journals Demyelination and remyelination detected in an alternative cuprizone mouse model of multiple sclerosis with 7.0 T multiparameter magnetic resonance imaging

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuang Ding ◽  
Yu Guo ◽  
Xiaoya Chen ◽  
Silin Du ◽  
Yongliang Han ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Blue Staining ◽  
Resonance Imaging ◽  
The Mean ◽  
Underlying Mechanisms

AbstractThe aim of this study was to investigate the mechanisms underlying demyelination and remyelination with 7.0 T multiparameter magnetic resonance imaging (MRI) in an alternative cuprizone (CPZ) mouse model of multiple sclerosis (MS). Sixty mice were divided into six groups (n = 10, each), and these groups were imaged with 7.0 T multiparameter MRI and treated with an alternative CPZ administration schedule. T2-weighted imaging (T2WI), susceptibility-weighted imaging (SWI), and diffusion tensor imaging (DTI) were used to compare the splenium of the corpus callosum (sCC) among the groups. Prussian blue and Luxol fast blue staining were performed to assess pathology. The correlations of the mean grayscale value (mGSV) of the pathology results and the MRI metrics were analyzed to evaluate the multiparameter MRI results. One-way ANOVA and post hoc comparison showed that the normalized T2WI (T2-nor), fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) values were significantly different among the six groups, while the mean phase (Φ) value of SWI was not significantly different among the groups. Correlation analysis showed that the correlation between the T2-nor and mGSV was higher than that among the other values. The correlations among the FA, RD, MD, and mGSV remained instructive. In conclusion, ultrahigh-field multiparameter MRI can reflect the pathological changes associated with and the underlying mechanisms of demyelination and remyelination in MS after the successful establishment of an acute CPZ-induced model.

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