Importance of Early Microbial Colonization for Intestinal Immune Development

Author(s):  
P. Brandtzaeg
2014 ◽  
Vol 77 (1-2) ◽  
pp. 189-195 ◽  
Author(s):  
Joann Romano-Keeler ◽  
Jörn-Hendrik Weitkamp

2020 ◽  
Author(s):  
C Urbschat ◽  
S Schepanski ◽  
M.E Solano ◽  
I Stelzer ◽  
N Fischer ◽  
...  

2020 ◽  
Vol 91 (8) ◽  
pp. 651-661
Author(s):  
Joshua T. Davis ◽  
Hilary A. Uyhelji

INTRODUCTION: Although the impact of microorganisms on their hosts has been investigated for decades, recent technological advances have permitted high-throughput studies of the collective microbial genomes colonizing a host or habitat, also known as the microbiome. This literature review presents an overview of microbiome research, with an emphasis on topics that have the potential for future applications to aviation safety. In humans, research is beginning to suggest relationships of the microbiome with physical disorders, including type 1 and type 2 diabetes mellitus, cardiovascular disease, and respiratory disease. The microbiome also has been associated with psychological health, including depression, anxiety, and the social complications that arise in autism spectrum disorders. Pharmaceuticals can alter microbiome diversity, and may lead to unintended consequences both short and long-term. As research strengthens understanding of the connections between the microbiota and human health, several potential applications for aerospace medicine and aviation safety emerge. For example, information derived from tests of the microbiota has potential future relevance for medical certification of pilots, accident investigation, and evaluation of fitness for duty in aerospace operations. Moreover, air travel may impact the microbiome of passengers and crew, including potential impacts on the spread of disease nationally and internationally. Construction, maintenance, and cleaning regimens that consider the potential for microbial colonization in airports and cabin environments may promote the health of travelers. Altogether, the mounting knowledge of microbiome effects on health presents several opportunities for future research into how and whether microbiome-based insights could be used to improve aviation safety.Davis JT, Uyhelji HA. Aviation and the microbiome. Aerosp Med Hum Perform. 2020; 91(8):651–661.


2019 ◽  
pp. 32-37
Author(s):  
L.N. BAKAEVA ◽  
A.S. KARAMAEVA ◽  
S.V. KARAMAEV

Работа  посвящена изучению особенностей формирования иммунитета у новорожденных телят. Объектом исследований служили коровы бестужевской, черно-пестрой, голштинской, айрширской пород и их потомство, разводимые в природно-климатической зоне Среднего Поволжья и Южного Урала. Установлено, что за последний месяц перед отелом в сыворотке крови коров происходит снижение содержания иммуноглобулинов, у бестужевской породы на 19,3%, черно-пестрой — на 15,8%, голштинской — на 13,4%, айрширской — на 15,0%. Это обусловлено тем, что иммуноглобулины интенсивно перемещаются в клетки секреторного эпителия альвеолярной ткани вымени. В молозиве первого удоя содержится от 57,86 г/л (голштинская порода) до 106,78 г/л (бестужевская порода) иммуноглобулинов. В молозиве второго удоя содержание иммуноглобулинов снижается у бестужевской породы на 18,9%, черно-пестрой — на 25,1%, голштинской — на 29,3%, айрширской — на 21,7%, а при четвертом доении, соответственно, на 45,4; 51,6; 52,4; 49,2%. Через 6 ч после первого выпаивания молозивом, содержание иммуноглобулинов в сыворотке крови телят всех пород, за исключением голштинской, было выше 10 мг/мл, что считается физиологической нормой. Исследования показали, что в каждой породе есть телята, не воспринимающие иммуноглобулины из молозива матери, доля которых составляет, соответственно 20; 16; 30; 10%. Наиболее опасными для здоровья теленка являются первые 5 дней жизни. В этот период в бестужевской породе заболело 6% телят, черно-пестрой — 24, голштинской — 42, айрширской — 14%. Всего за первый месяц жизни заболеваемость телят в группах составила, соответственно, 16; 48; 76; 26%.The article presents the study of peculiarities of immune development in newborn calves. The objects of interest were Bestuzhev, Black-and-White, Holstein and Ayrshire cows and their progeny raised in the environmental and climatic zone of Middle Volga and Southern Ural. The study has shown that during the last month prior to calving there was a decrease of immunoglobulin content in the cows’ blood serum: in Bestuzhev cows by 19.3%, in Black-and-White cows by 15.8%, in Holstein cows by 13.4% and in Ayrshire cows by 15.0%. This is due to the fact that immunoglobulins massively migrate to secretory epithelium cells of the udder alveolar tissue. Immunoglobulin concentration in the first milking colostrum was from 57.86 g/l (Holstein cows) up to 106.78 g/l (Bestuzhev cows). In the second milking colostrum the content of immunoglobulins was decreased by 18.9% in Bestuzhev cows, by 25.1% in Black-and-White cows, by 29.3% in Holstein cows and by 21.7% in Ayrshire cows, in the forth milking colostrum the decrease was respectively by 45.4; 51.6; 52.4 and 49.2%. 6 hours after the first colostrum feeding immunoglobulin content in blood serum of calves of all breeds except for Holstein one exceeded 10 mg/ml, what was within the physiological norm. The study has shown that there were calves in every breed who did not accept immunoglobulins from the mother’s colostrum, their percentage was respectively 20; 16; 30 and 10%. The first five days of life were the most dangerous for the health of calves. During the period 6% Bestuzhev calves, 24% Black-and-White calves, 42 Holstein calves and 14% Ayrshire calves fell ill. During the fist month of life the morbidity rate of calves was respectively 16; 48; 76 and 26%.


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