scholarly journals Staphylococcus aureusProteases Degrade Lung Surfactant Protein A Potentially Impairing Innate Immunity of the Lung

2013 ◽  
Vol 5 (3) ◽  
pp. 251-260 ◽  
Author(s):  
Tomasz Kantyka ◽  
Krzysztof Pyrc ◽  
Milosz Gruca ◽  
Jan Smagur ◽  
Karolina Plaza ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Lung Surfactant Protein

Phagocyte-Bacteria Interactions

1997 ◽  
Vol 11 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Y. Keisari ◽  
K. Kabha ◽  
L. Nissimov ◽  
J. Schlepper-Schafer ◽  
I. Ofek
Keyword(s):  
Innate Immunity ◽  
Klebsiella Pneumoniae ◽  
Lung Surfactant ◽  
Protein A ◽  
Immunocompromised Host ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Capsular Polysaccharides ◽  
Lung Surfactant Protein ◽  
Mannose Receptors

Recognition and phagocytosis of microorganisms in a serum-poor environment represent innate immunity against many extracellular pathogens. As a paradigm for such processes, we discuss the recognition of Klebsiella pneumoniae by alveolar macrophages and monocyte-derived macrophages in the absence of serum. Macrophages recognize and subsequently kill Klebsiella expressing Man-a2/3-Man or Rha-a2/3-Rha sequences in their capsular polysaccharides by two mechanisms: (a) recognition of the capsular structures by macrophage mannose receptors, and (b) opsonization by the lung surfactant protein A (SP-A), which binds to the capsular polysaccharides of Klebsiella and to SP-A receptors on the macrophages. Sp-A may also enhance phagocytosis by increasing the activity of macrophage mannose receptors. We conclude that a specific microbial surface structure may be a target for recognition by macrophages via several mechanisms, as exemplified in the case of Klebsiella capsular polysaccharides. Multiple recognition mechanisms of pathogens by macrophages may be essential to provide innate immunity to reduce the frequency of infections caused by a relatively less virulent bacterium in the immunocompromised host.

scholarly journals Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 ◽  
Vol 168 (12) ◽  
pp. 5989-5992 ◽  
Author(s):  
Loïc Guillot ◽  
Viviane Balloy ◽  
Francis X. McCormack ◽  
Douglas T. Golenbock ◽  
Michel Chignard ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Immunostimulatory Activity ◽  
Toll Like Receptor 4 ◽  
Lung Surfactant Protein

Expression and Localization of Lung Surfactant Protein A in Human Tissues

2003 ◽  
Vol 29 (5) ◽  
pp. 591-597 ◽  
Author(s):  
Jens Madsen ◽  
Ida Tornøe ◽  
Ole Nielsen ◽  
Claus Koch ◽  
Wolfram Steinhilber ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Human Tissues ◽  
Lung Surfactant Protein

scholarly journals Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry ◽  
2016 ◽  
Vol 55 (26) ◽  
pp. 3692-3701 ◽  
Author(s):  
Boon Chong Goh ◽  
Huixing Wu ◽  
Michael J. Rynkiewicz ◽  
Klaus Schulten ◽  
Barbara A. Seaton ◽  
...  
Keyword(s):  
Binding Sites ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Lipid Binding ◽  
Surfactant Protein A ◽  
X Ray ◽  
X Ray Crystallography ◽  
Lung Surfactant Protein ◽  
Dynamics Simulations

scholarly journals Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A

2021 ◽  
pp. 112551
Author(s):  
Susana Carregal-Romero ◽  
Hugo Groult ◽  
Olga Cañadas ◽  
Noelia A-Gonzalez ◽  
Ana Victoria Lechuga-Vieco ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Coating Composition ◽  
Lung Surfactant Protein
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