The Impact of Adverse Life Events on Clinical Features and Interaction with Gene Variants in Mood Disorder Patients

2013 ◽  
Vol 46 (6) ◽  
pp. 384-389 ◽  
Author(s):  
Alessandro Serretti ◽  
Daniel Souery ◽  
Niki Antypa ◽  
Raffaella Calati ◽  
Othman Sentissi ◽  
...  
2017 ◽  
Vol 40 (4) ◽  
pp. 676-683 ◽  
Author(s):  
E Prayogo ◽  
A Chater ◽  
S Chapman ◽  
M Barker ◽  
N Rahmawati ◽  
...  

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Deva Rangarajan ◽  
Michael Peasley ◽  
Bert Paesbrugghe ◽  
Rajesh V. Srivastava ◽  
Geoffrey T. Stewart

Purpose This study aims to examine the impact of stress as a result of adverse life events on a salesperson’s ability to effectively manage customer relationships. The framework identifies burnout as a key mediating variable and salesperson grit as a coping mechanism. Design/methodology/approach Survey data is gathered from 364 B2B salespeople and investigated using structural equation modeling in Mplus 8.2. Findings The findings reveal adverse life events and their corresponding stress diminish a salesperson’s ability to manage customer relationships effectively through the mediators of reduced personal accomplishment and depersonalization. Thus, negative events of a personal nature can have a significant impact on salesperson outcomes and should be taken with the same level of seriousness as job-related stress. Furthermore, results show that salesperson grit provides mixed results as a coping mechanism. Practical implications The findings indicate that practitioners should be mindful of the negative impact adverse life events can have on work-related outcomes. Organizations and sales managers must be intentional in managing relationships with their salespeople and strategic in the structure they use to manage customer relationships. Recommendations include the use of regular one-on-one meetings to open up a dialogue about work or personal issues the salesperson is experiencing and assigning multiple resources or staff to service valuable customers, thereby not relying on solitary salespeople. Originality/value Employee well-being contributes to firm value; yet, this is the first study in sales to explore the impact of adverse life events on salesperson outcomes.


2003 ◽  
Vol 33 (7) ◽  
pp. 1169-1175 ◽  
Author(s):  
ANNE E. FARMER ◽  
PETER McGUFFIN

Background. It has been proposed that adverse life events involving loss or humiliation are particularly potent in provoking depressive episodes. We have also previously suggested that experiencing high rates of non-severe events may play a role in the development of resilience to the impact of severe threatening events when these occur.Method. The Life Events and Difficulties Schedule (LEDS) (Brown & Harris, 1978) was used to record the life events experienced by 108 depressed probands and their nearest aged siblings as well as 105 healthy control subjects and their nearest aged siblings. All subjects were interviewed using the Schedule for the Clinical Assessment of Neuropsychiatry (SCAN) (Wing et al. 1990).Results. Depressed probands were significantly more likely to have experienced a severe threatening event, loss event, or a humiliation event compared to the other subjects. These events also made up a greater proportion of the total number of events, in the depressed probands. Humiliation events were more frequent in depressed men than depressed women. There were no differences between the four groups for experiencing a non-severe event, although depressed probands also experienced more difficulties than the other three groups. Fifty-six healthy subjects who had not become depressed despite having experienced at least one severe and threatening event, had significantly more non-severe events, than the 116 subjects who were depressed at the time of interview.Conclusions. The findings support the hypothesis that loss and humiliation events are particularly depressogenic. Experiencing a high rate of non-severe events may be associated with resilience to becoming depressed in the face of a threatening event.


2021 ◽  
Vol 8 ◽  
Author(s):  
Vjenka Garms-Homolová ◽  
Anja Declercq ◽  
Harriet Finne-Soveri ◽  
Nanna Notthoff ◽  
Henriëtte G. van der Roest ◽  
...  

Objectives: Research on life stressors and adverse life events has a long tradition. Few studies have addressed this topic in connection to very old people. Life stressors, especially major life stressors (MLSs) experienced by clients of home care services in the community have rarely been the subject of studies. Considering this gap, we investigated the prevalence of MLSs in home care clients. We examined the effects that MLSs have on their mood and health status as well as the impact of clients' social resources on MLSs and their outcomes.Method: We used assessment data from 2,884 home care clients in six European countries. The methodological basis was the comprehensive and standardized interRAI Home Care Assessment (interRAI HC).Results: Fifteen point four percent of the sample—that consisted of women and men with an average age of 82.89 years–experienced an MLS in the last 6 months before the assessment. They were more depressed than persons without these experiences, and their health status indicated a higher level of instability and deterioration. At reassessment after 6 months, the situation changed. Despite the fact that both outcomes of the MLSs, depression and health status became worse in the reassessment-sample, home care clients without MLS were more affected by the worsening, especially that of depression. The expected buffering impact of social resources was low.Discussion: Although this study worked with limited information on MLSs, it could contribute to closing various knowledge gaps. The study shows that the MLSs represent a prevalent problem in a population of home care clients and that this problem has negative consequences for their mood and the stability of their health status. Furthermore, this research took up the situation of very old and vulnerable adults, who have previously rarely been considered in studies on major critical life events and stressors.Conclusion and Research Perspective: Future research on MLSs has to take up the issue of the time passage between the MLS and the impact on health and well-being of individuals dependent on care. It has to determine immediate as well as later consequences and identify those factors that are appropriate to reduce the MLS-effects on very old people dependent on care.


2016 ◽  
Vol 209 (6) ◽  
pp. 483-490 ◽  
Author(s):  
Kamaldeep Bhui ◽  
Maria Joao Silva ◽  
Raluca A. Topciu ◽  
Edgar Jones

BackgroundRadicalisation is proposed to explain why some individuals begin to support and take part in violent extremism. However, there is little empirical population research to inform prevention, and insufficient attention to the role of psychiatric vulnerabilities.AimsTo test the impact of depressive symptoms, adverse life events and political engagement on sympathies for violent protest and terrorism (SVPT).MethodA cross-sectional survey of a representative sample of Pakistani and Bangladeshi men and women from two English cities. Weighted, multivariable, logistic regression yielded population estimates of association (odds ratio (OR) and 95% confidence intervals) against a binary outcome of SVPT derived from a three-group solution following cluster analysis.ResultsDepressive symptoms were associated with a higher risk of SVPT (OR = 2.59, 95% CI 1.59–4.23,P<0.001), but mediated little of the overall effects of life events and political engagement, which were associated with a lower risk of SVPT (death of a close friend: OR = 0.24, 95% CI 0.07–0.74; donating money to a charity: OR = 0.52, 95% CI 0.3–0.9).ConclusionsIndependent of SVPT associations with depressive symptoms, some expressions of social connectedness (measured as life events and political engagement) are associated with a lower risk of SVPT.


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