scholarly journals Prognosis in Patients with Non-Small Cell Lung Cancer Who Received Erlotinib Treatment and Subsequent Dose Reduction due to Skin Rash

Onkologie ◽  
2012 ◽  
Vol 35 (12) ◽  
pp. 747-752 ◽  
Author(s):  
Naoki Takashima ◽  
Tomoki Kimura ◽  
Naohiro Watanabe ◽  
Takumi Umemura ◽  
Shinya Katsuno ◽  
...  
2016 ◽  
Vol 9 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Jun Osugi ◽  
Yuki Owada ◽  
Takumi Yamaura ◽  
Satoshi Muto ◽  
Naoyuki Okabe ◽  
...  

Crizotinib, the first clinically available inhibitor of anaplastic lymphoma kinase (ALK) gene rearrangement, is generally well tolerated. In contrast, neutropenia induced by crizotinib is a commonly reported grade 3 or 4 adverse event. In such cases, interruption and dose reduction of crizotinib might be necessary for some patients with severe neutropenia. However, information concerning clinical experience and management of severe neutropenia is currently limited. In this report, the successful management of crizotinib-induced neutropenia by dose reduction of crizotinib in a patient with ALK-positive non-small cell lung cancer is described.


2021 ◽  
Vol 85 ◽  
pp. 57-62
Author(s):  
Hidetoshi Shimizu ◽  
Koji Sasaki ◽  
Takahiro Aoyama ◽  
Tohru Iwata ◽  
Tomoki Kitagawa ◽  
...  

2018 ◽  
Vol 56 (11) ◽  
pp. 551-554 ◽  
Author(s):  
Yohei Iimura ◽  
Hitoshi Shimomura ◽  
Takeo Yasu ◽  
Keiko Imanaka ◽  
Ryuichi Ogawa ◽  
...  

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