scholarly journals Double Mutation at the Putative Protein Kinase C Phosphorylation Sites Thr151Plus Thr323in the Mouse LeukotrieneD4Receptor Eliminates Homologous Desensitization

2013 ◽  
Vol 31 (2-3) ◽  
pp. 366-378 ◽  
Author(s):  
Sune T. Jørgensen ◽  
Heidi N. Eriksen ◽  
Janni Dausell ◽  
Thomas Jespersen ◽  
Ian H. Lambert ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phosphorylation Sites ◽  
Double Mutation ◽  
Putative Protein ◽  
Kinase C ◽  
Homologous Desensitization ◽  
Putative Protein Kinase

scholarly journals The Acidic Region and Conserved Putative Protein Kinase C Phosphorylation Site in Nef Are Important for SIV Replication in Rhesus Macaques

Virology ◽  
1999 ◽  
Vol 257 (1) ◽  
pp. 138-155 ◽  
Author(s):  
Silke Carl ◽  
A.John Iafrate ◽  
Sabine M. Lang ◽  
Christiane Stahl-Hennig ◽  
Eva M. Kuhn ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rhesus Macaques ◽  
Phosphorylation Site ◽  
Putative Protein ◽  
Kinase C ◽  
Acidic Region ◽  
Putative Protein Kinase

Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle

1993 ◽  
Vol 264 (4) ◽  
pp. H1300-H1306 ◽  
Author(s):  
Y. Shimamoto ◽  
H. Shimamoto ◽  
C. Y. Kwan ◽  
E. E. Daniel
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Kinases ◽  
Induced Response ◽  
Dependent Manner ◽  
Contractile Responses ◽  
Putative Protein ◽  
Calphostin C ◽  
Kinase C ◽  
Putative Protein Kinase

We investigated effects of three kinds of putative protein kinase C (PKC) inhibitors, calphostin C, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and stauro-sporine, on aortic muscle contractions induced by KCl, phenylephrine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and phorbol 12, 13-dibutyrate (PDBu). Calphostin C noncompetitively inhibited TPA-induced contractions in a concentration-dependent manner. At 10(-6) M, calphostin C completely abolished responses to TPA and also effectively inhibited PDBu-induced contractions. Such a concentration of calphostin C had no effect on KCl-induced contractions but decreased the maximal tension of phenylephrine-induced response curve by 35.3 +/- 6.6% H-7 (10(-5) M had little effect on TPA-induced contraction but significantly inhibited contractile responses to phenylephrine and KCl. Staurosporine (10(-8) M, 3 x 10(-8) M) inhibited contractile responses to KCl, phenylephrine, and TPA. We suggest that staurosporine and H-7, which are known to act on the catalytic domain of PKC carrying high degree of sequence homology with other protein kinases, are relatively nonselective for PKC. On the other hand, calphostin C acting on the regulatory domain of PKC, which is distinct from other protein kinases, may serve as a relatively more selective PKC inhibitor.

scholarly journals Phospholipase C-eta Enzymes as Putative Protein Kinase C and Ca2+ Signalling Components in Neuronal and Neuroendocrine Tissues

2007 ◽  
Vol 86 (4) ◽  
pp. 243-248 ◽  
Author(s):  
Alan J. Stewart ◽  
Kevin Morgan ◽  
Colin Farquharson ◽  
Robert P. Millar
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Putative Protein ◽  
Kinase C ◽  
Putative Protein Kinase

Role of a geminivirus AV2 protein putative protein kinase C motif on subcellular localization and pathogenicity

2008 ◽  
Vol 135 (1) ◽  
pp. 115-124 ◽  
Author(s):  
R.V. Chowda-Reddy ◽  
Fidelis Achenjang ◽  
Christian Felton ◽  
Marie T. Etarock ◽  
Marie-Therese Anangfac ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Subcellular Localization ◽  
Putative Protein ◽  
Kinase C ◽  
Putative Protein Kinase
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