Stromal Cell-Derived Factor-1 Enhances Wound Healing through Recruiting Bone Marrow-Derived Mesenchymal Stem Cells to the Wound Area and Promoting Neovascularization

2013 ◽  
Vol 197 (2) ◽  
pp. 103-113 ◽  
Author(s):  
Xiang Xu ◽  
Fangqiang Zhu ◽  
Meng Zhang ◽  
Dengfen Zeng ◽  
Donglin Luo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Stromal Cell ◽  
Wound Area ◽  
Stromal Cell Derived Factor

scholarly journals Enhanced wound healing by topical administration of mesenchymal stem cells transfected with stromal cell-derived factor-1

Biomaterials ◽  
2013 ◽  
Vol 34 (37) ◽  
pp. 9393-9400 ◽  
Author(s):  
Yoko Nakamura ◽  
Hidefumi Ishikawa ◽  
Katsuya Kawai ◽  
Yasuhiko Tabata ◽  
Shigehiko Suzuki
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Stromal Cell ◽  
Topical Administration ◽  
Stromal Cell Derived Factor

scholarly journals Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome

Blood ◽  
2012 ◽  
Vol 120 (15) ◽  
pp. 3142-3151 ◽  
Author(s):  
Junji Xu ◽  
Dandan Wang ◽  
Dayong Liu ◽  
Zhipeng Fan ◽  
Huayong Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stromal Cell ◽  
Sjogren Syndrome ◽  
Stromal Cell Derived Factor ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

Abstract Sjögren syndrome (SS) is a systemic autoimmune disease characterized by dry mouth and eyes, and the cellular and molecular mechanisms for its pathogenesis are complex. Here we reveal, for the first time, that bone marrow mesenchymal stem cells in SS-like NOD/Ltj mice and human patients were defective in immunoregulatory functions. Importantly, treatment with mesenchymal stem cells (MSCs) suppressed autoimmunity and restored salivary gland secretory function in both mouse models and SS patients. MSC treatment directed T cells toward Treg and Th2, while suppressing Th17 and Tfh responses, and alleviated disease symptoms. Infused MSCs migrated toward the inflammatory regions in a stromal cell–derived factor-1–dependent manner, as neutralization of stromal cell–derived factor-1 ligand CXCR4 abolished the effectiveness of bone marrow mesenchymal stem cell treatment. Collectively, our study suggests that immunologic regulatory functions of MSCs play an important role in SS pathogenesis, and allogeneic MSC treatment may provide a novel, effective, and safe therapy for patients with SS. This study was registered at www.clinicaltrials.gov as NCT00953485.

scholarly journals Stromal Cell-Derived Factor-1β Mediates Cell Survival through Enhancing Autophagy in Bone Marrow-Derived Mesenchymal Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58207 ◽  
Author(s):  
Samuel Herberg ◽  
Xingming Shi ◽  
Maribeth H. Johnson ◽  
Mark W. Hamrick ◽  
Carlos M. Isales ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Survival ◽  
Stromal Cell ◽  
Stromal Cell Derived Factor
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