scholarly journals Primary Generalized Familial and Sporadic Glucocorticoid Resistance (Chrousos Syndrome) and Hypersensitivity

2013 ◽  
pp. 67-85 ◽  
Author(s):  
Evangelia Charmandari ◽  
Tomoshige Kino ◽  
George P. Chrousos
Keyword(s):  
Glucocorticoid Resistance

Glucocorticoid resistance may be implicated in the emergence of ETV6/RUNX1- positive relapses

2011 ◽  
Vol 223 (03) ◽  
Author(s):  
R Grausenburger ◽  
L Kuster ◽  
A Inthal ◽  
R Panzer-Grümayer
Keyword(s):  
Glucocorticoid Resistance

Glucocorticoid resistance patients exhibit defective cortisol metabolism, responsible for functional hypermineralocorticism

2019 ◽  
Author(s):  
Geraldine Vitellius ◽  
Brigitte Delemer ◽  
Olivier Chabre ◽  
Philippe Caron ◽  
Eric Pussard ◽  
...  
Keyword(s):  
Glucocorticoid Resistance ◽  
Cortisol Metabolism

scholarly journals Glucocorticoid resistance conferring mutation in the C-terminus of GR alters the receptor conformational dynamics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna Kaziales ◽  
Florian Rührnößl ◽  
Klaus Richter
Keyword(s):  
Glucocorticoid Receptor ◽  
Steroid Hormones ◽  
In Silico ◽  
Conformational Dynamics ◽  
Glucocorticoid Resistance ◽  
Physiological Processes ◽  
C Terminus ◽  
Hsp90 Chaperone ◽  
In Silico Methods

AbstractThe glucocorticoid receptor is a key regulator of essential physiological processes, which under the control of the Hsp90 chaperone machinery, binds to steroid hormones and steroid-like molecules and in a rather complicated and elusive response, regulates a set of glucocorticoid responsive genes. We here examine a human glucocorticoid receptor variant, harboring a point mutation in the last C-terminal residues, L773P, that was associated to Primary Generalized Glucocorticoid Resistance, a condition originating from decreased affinity to hormone, impairing one or multiple aspects of GR action. Using in vitro and in silico methods, we assign the conformational consequences of this mutation to particular GR elements and report on the altered receptor properties regarding its binding to dexamethasone, a NCOA-2 coactivator-derived peptide, DNA, and importantly, its interaction with the chaperone machinery of Hsp90.

Sign in / Sign up

Export Citation Format

Share Document