scholarly journals The Role of the Host Defense System in the Development of Cerebral Vasospasm: Analogies between Atherosclerosis and Subarachnoid Hemorrhage

2012 ◽  
Vol 68 (6) ◽  
pp. 329-343 ◽  
Author(s):  
Hiroji Yanamoto ◽  
Hiroharu Kataoka ◽  
Yukako Nakajo ◽  
Koji Iihara
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Host Defense ◽  
Defense System ◽  
Host Defense System

A role of uroleuconaphins, polyketide red pigments in aphid, as a chemopreventor in the host defense system against infection with entomopathogenic fungi

2018 ◽  
Vol 71 (12) ◽  
pp. 992-999
Author(s):  
Mitsuyo Horikawa ◽  
Mitsuaki Shimazu ◽  
Maki Aibe ◽  
Hiroto Kaku ◽  
Makoto Inai ◽  
...  
Keyword(s):  
Host Defense ◽  
Entomopathogenic Fungi ◽  
Defense System ◽  
Red Pigments ◽  
Host Defense System

scholarly journals The Two-Faced Cytokine IL-6 in Host Defense and Diseases

2018 ◽  
Vol 19 (11) ◽  
pp. 3528 ◽  
Author(s):  
Masashi Narazaki ◽  
Tadamitsu Kishimoto
Keyword(s):  
Host Defense ◽  
Blood Stream ◽  
Castleman Disease ◽  
Whole Body ◽  
Off Label Use ◽  
Defense System ◽  
New Era ◽  
Pathological Conditions ◽  
Host Defense System

Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to the whole body via the blood stream, promptly activating the host defense system to perform diverse functions. However, excessive or sustained production of IL-6 is involved in various diseases. In diseases, the IL-6 inhibitory strategy begins with the development of the anti-IL-6 receptor antibody, tocilizumab (TCZ). This antibody has shown remarkable effects on Castleman disease, rheumatoid arthritis and juvenile idiopathic arthritis. In 2017, TCZ was proven to work effectively against giant cell arteritis, Takayasu arteritis and cytokine releasing syndrome, initiating a new era for the treatment of these diseases. In this study, the defensive functions of IL-6 and various pathological conditions are compared. Further, the diseases of which TCZ has been approved for treatment are summarized, the updated results of increasing off-label use of TCZ for various diseases are reviewed and the conditions for which IL-6 inhibition might have a beneficial role are discussed. Given the involvement of IL-6 in many pathologies, the diseases that can be improved by IL-6 inhibition will expand. However, the important role of IL-6 in host defense should always be kept in mind in clinical practice.

scholarly journals Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections

2015 ◽  
Vol 8 (1) ◽  
pp. 5 ◽  
Author(s):  
Chisa Abe ◽  
Sachi Tanaka ◽  
Maki Nishimura ◽  
Fumiaki Ihara ◽  
Xuenan Xuan ◽  
...  
Keyword(s):  
Host Defense ◽  
Chemokine Receptor ◽  
Neospora Caninum ◽  
Defense System ◽  
Chemokine Receptor Ccr5 ◽  
Host Defense System ◽  
Receptor Ccr5

scholarly journals Role of the Host Defense System and Intestinal Microbial Flora in the Pathogenesis of Necrotizing Enterocolitis

2009 ◽  
Vol 10 (5) ◽  
pp. 407-417 ◽  
Author(s):  
Claudia N. Emami ◽  
Mikael Petrosyan ◽  
Stefano Giuliani ◽  
Monica Williams ◽  
Catherine Hunter ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Host Defense ◽  
Microbial Flora ◽  
Defense System ◽  
Intestinal Microbial Flora ◽  
Host Defense System

scholarly journals Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System

1995 ◽  
Vol 108 (4) ◽  
pp. 1353-1358 ◽  
Author(s):  
W. F. Broekaert ◽  
FRG. Terras ◽  
BPA. Cammue ◽  
R. W. Osborn
Keyword(s):  
Antimicrobial Peptides ◽  
Host Defense ◽  
Defense System ◽  
Plant Defensins ◽  
Host Defense System
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