Effectiveness of Low-Frequency rTMS and Intensive Speech Therapy in Poststroke Patients with Aphasia: A Pilot Study Based on Evaluation by fMRI in Relation to Type of Aphasia

2012 ◽  
Vol 68 (4) ◽  
pp. 199-208 ◽  
Author(s):  
Masahiro Abo ◽  
Wataru Kakuda ◽  
Motoi Watanabe ◽  
Azusa Morooka ◽  
Katsuya Kawakami ◽  
...  
Keyword(s):  
Pilot Study ◽  
Speech Therapy ◽  
Low Frequency ◽  
Low Frequency Rtms

Effect of Low-Frequency rTMS and Intensive Speech Therapy Treatment on Patients With Nonfluent Aphasia After Stroke

2020 ◽  
Vol 26 (1) ◽  
pp. 6-9
Author(s):  
Guangtao Bai ◽  
Liang Jiang ◽  
Wenshuai Ma ◽  
Pingping Meng ◽  
Jiang Li ◽  
...  
Keyword(s):  
Speech Therapy ◽  
Low Frequency ◽  
Nonfluent Aphasia ◽  
Low Frequency Rtms ◽  
Therapy Treatment

Therapeutic application of 6-Hz-primed low-frequency rTMS combined with intensive speech therapy for post-stroke aphasia

Brain Injury ◽  
2011 ◽  
Vol 25 (12) ◽  
pp. 1242-1248 ◽  
Author(s):  
Wataru Kakuda ◽  
Masahiro Abo ◽  
Ryo Momosaki ◽  
Azusa Morooka
Keyword(s):  
Speech Therapy ◽  
Low Frequency ◽  
Therapeutic Application ◽  
Post Stroke ◽  
Low Frequency Rtms

Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Cerebrovascular Disease Without Dementia

2008 ◽  
Vol 22 (1) ◽  
pp. 14-19 ◽  
Author(s):  
S. Sedlackova ◽  
I. Rektorova ◽  
Z. Fanfrdlova ◽  
I. Rektor
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Specific Effect ◽  
Frameless Stereotaxy ◽  
Stimulation Site ◽  
Positive Effects ◽  
Vascular Type ◽  
Low Frequency Rtms

Aims: The results of our pilot study suggested that one session of high frequency rTMS applied over the left dorsolateral prefrontal cortex (DLPFC) might induce measurable positive effects on executive functioning in patients with mild cognitive impairment of the vascular type without dementia (MCI-V). The aims of the current study were to replicate the results of our pilot study using a frameless stereotaxy as opposed to the standard and routinely used procedure. We also studied the effects of low frequency rTMS. Patients and method: Seven patients with MCI-V participated in a randomized, controlled, blind study with a crossover design. Each patient received 10 Hz and 1 Hz stimulation over the left DLPFC (an active stimulation site) or the motor cortex (MC; a control stimulation site). Frameless stereotaxy was used to target the DLPFC. The order of sites and frequencies was randomized. A short battery of neuropsychological tests was performed to evaluate executive function, working memory, and psychomotor speed. Results: One session of both high and low frequency rTMS was well tolerated and safe in terms of the cognitive after-effects in patients with MCI-V. We did not observe any significant frequency dependent or stimulation site-dependent cognitive effects of rTMS. Conclusion: We found neither positive nor negative significant effect of either low or high frequency rTMS applied over the DLPFC or the MC, while a mild positive site-specific effect of 10 Hz rTMS was observed in our pilot study on the Stroop interference results. These results suggested that MCI-V is a heterogeneous and poorly defined entity and, thus, rTMS might be useful in a subpopulation of this group of patients.

Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study

2020 ◽  
Vol 32 (6) ◽  
pp. 328-338
Author(s):  
Poul Erik Buchholtz ◽  
Mahmoud Ashkanian ◽  
Simon Hjerrild ◽  
Line Kirstine Hauptmann ◽  
Torben Albert Devantier ◽  
...  
Keyword(s):  
Placebo Group ◽  
Pilot Study ◽  
Major Depression ◽  
Negative Impact ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Double Blind Study ◽  
Depressant Effect ◽  
Significant Difference ◽  
Low Frequency Rtms

AbstractObjective:Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.Methods:In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.

Effects of anodal HD-tDCS or low-frequency rTMS on ipsilateral and contralateral M1 excitability: A pilot study

2017 ◽  
Vol 10 (2) ◽  
pp. 461-462
Author(s):  
V. Cabibel ◽  
J. Froger ◽  
M. Muthalib ◽  
S. Perrey
Keyword(s):  
Pilot Study ◽  
Low Frequency ◽  
Low Frequency Rtms

scholarly journals Individualized Responses to Ipsilesional High-Frequency and Contralesional Low-Frequency rTMS in Chronic Stroke: A Pilot Study to Support the Individualization of Neuromodulation for Rehabilitation

2020 ◽  
Vol 14 ◽  
Author(s):  
John Harvey Kindred ◽  
Elizabeth Carr Wonsetler ◽  
Charalambos Costas Charalambous ◽  
Shraddha Srivastava ◽  
Barbara Khalibinzwa Marebwa ◽  
...  
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Low Frequency ◽  
Chronic Stroke ◽  
Low Frequency Rtms

scholarly journals Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Teresa Leao ◽  
Kathrin Machetanz ◽  
Joey Sandritter ◽  
Marina Liebsch ◽  
Andreas Stengel ◽  
...  
Keyword(s):  
Pilot Study ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Acute Effect ◽  
Term Effect ◽  
Long Term Effect ◽  
The Right ◽  
Low Frequency Rtms ◽  
Present Pilot Study

Background: Vestibular schwannomas (VS) are brain tumors affecting the vestibulocochlear nerve. Thus, VS patients suffer from tinnitus (TN). While the pathophysiology is mainly unclear, there is an increasing interest in repetitive transcranial magnetic stimulation (rTMS) for TN treatment. However, the results have been divergent. In addition to the methodological aspects, the heterogeneity of the patients might affect the outcome. Yet, there is no study evaluating rTMS exclusively in VS-associated tinnitus. Thus, the present pilot study evaluates low-frequency rTMS to the right dorsolateral pre-frontal cortex (DLPFC) in a VS-associated tinnitus.Methods: This prospective pilot study enrolled nine patients with a monoaural VS-associated tinnitus ipsilateral to the tumor. Patients were treated with a 10-day rTMS regime (1 Hz, 100% RMT, 1,200 pulses, right DLPFC). The primary endpoint of the study was the reduction of TN distress (according to the Tinnitus Handicap Inventory, THI). The secondary endpoint was a reduction of TN intensity (according to the Tinnitus Matching Test, TMT) and the evaluation of factors predicting tinnitus outcome (i.e., hearing impairment, TN duration, type of tinnitus).Results: No complications or side effects occurred. There was one drop-out due to a non-responsiveness of the complaint. There was a significant acute effect of rTMS on the THI and TMT. However, there was no significant long-term effect after 4 weeks. While the THI failed to detect any clinically relevant acute effect of rTMS in 56% of the patients, TMT revealed a reduction of TN intensity for more than 20 in 89% and for more than 50 in 56% of the patients. Notably, the acute effect of rTMS was influenced by the TN type and duration. In general, patients with a tonal TN and shorter TN duration showed a better response to the rTMS therapy.Conclusion: The present pilot study is the first one to exclusively evaluate the effect of low-frequency rTMS to the right DLPFC in a VS-associated tinnitus. Our results prove the feasibility and the efficacy of rTMS in this patient cohort. There is a significant acute but a limited long-term effect. In addition, there is evidence that patients with a tonal tinnitus and shorter tinnitus duration might have the strongest benefit. A larger, randomized controlled study is necessary to prove these initial findings.

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