scholarly journals Cockroach Allergen per a 7 Down-Regulates Expression of Toll-Like Receptor 9 and IL-12 Release from P815 Cells Through PI3K and MAPK Signaling Pathways

2012 ◽  
Vol 29 (3-4) ◽  
pp. 561-570 ◽  
Author(s):  
Haiwei Yang ◽  
Xue Kong ◽  
Jifu Wei ◽  
Chengcheng Liu ◽  
Weijuan Song ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Toll Like Receptor ◽  
Cockroach Allergen ◽  
Mapk Signaling Pathways

scholarly journals Engelharquinone suppresses lipopolysaccharide-induced inflammation and proliferation of human liver cancer SMCC7721 cells via inhibition of NF-κB and MAPK signaling pathway

2020 ◽  
Vol 19 (4) ◽  
pp. 699-706
Author(s):  
Shan Li ◽  
Yan Zhang ◽  
Aishe Gao ◽  
Yue Zhang ◽  
Jiong Zhang
Keyword(s):  
Liver Cancer ◽  
Tumor Growth ◽  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Human Liver ◽  
Mapk Signaling ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Human Liver Cancer ◽  
Mapk Signaling Pathways

Purpose: To investigate the anti-tumor effect of engelharquinone (Eng) on human liver cancer SMCC7721 cells.Methods: GFP-labeled SMCC7721 cells were used to establish a tumor-bearing mice model used for determination of the effect of different  concentrations of Eng on tumor growth. The effect of Eng on SMCC7721 cell viability was determined with MTT assay and cell cycle analysis. The anti-inflammatory effect of Eng on lipopolysaccharide (LPS)-treated SMCC7721 cells were determined through assay of pro-inflammatory cytokines. Besides, the effect of Eng on the expressions of mitogen-activated protein kinase (MAPK), toll-like receptor 4 (TLR4), and nuclear factor kappa B (NF-κB) was determined.Results: Cell proliferation was suppressed by different concentrations of Eng in LPS-treated SMCC7721 cells. Treatment of nude mice with Eng at high and low doses resulted in significant suppression of tumor growth and marked increases in percentage survival. Treatment of SMCC7721 cells with LPS upregulated the expressions of NF-κB, p65 and MAPK. However, pre-treatment of the cells with Eng suppressed the LPS-induced upregulation of the NF-κB, p65 and MAPK signaling pathways, and further downregulated the production of inflammatory cytokines in SMCC7721 cells.Conclusion: These results indicate that Eng inhibits LPS-induced inflammation and proliferation of human liver cancer SMCC7721 cells via a mechanism involving regulation of NF-κB and MAPK signaling pathways. Thus, Eng has potentials for the clinical management of inflammatory diseases and liver cancer. Keywords: Inflammation, Engelharquinone, Lipopolysaccharide, SMCC7721 cells, Toll-like receptor 4

scholarly journals Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways

2021 ◽  
Vol 83 ◽  
pp. 104547
Author(s):  
Zhenzhen Cheng ◽  
Jingjing Tu ◽  
Hongpan Zhang ◽  
Yi zhang ◽  
Benhong Zhou
Keyword(s):  
Signaling Pathways ◽  
Renal Fibrosis ◽  
Mapk Signaling ◽  
Urolithin A ◽  
Mapk Signaling Pathways ◽  
Tgf Β1

6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 2192-2204 ◽  
Author(s):  
Chang Liu ◽  
Xin Tang ◽  
Wenjing Zhang ◽  
Guohong Li ◽  
Yingyu Chen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152104 ◽  
Author(s):  
Francesco Pappalardo ◽  
Giulia Russo ◽  
Saverio Candido ◽  
Marzio Pennisi ◽  
Salvatore Cavalieri ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Melanoma Cancer ◽  
Mapk Signaling Pathways

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 ◽  
Vol 20 (4) ◽  
pp. 151-156 ◽  
Author(s):  
J INGLESE ◽  
W KOCH ◽  
K TOUHARA ◽  
R LEFKOWITZ
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Ph Domains ◽  
Mapk Signaling Pathways
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