Age-Dependent Role of Vasopressin in Susceptibility of Gastric Mucosa to Indomethacin-Induced Injury

2012 ◽  
pp. 219-229
Author(s):  
D. Zelena ◽  
O. Yu Morozova ◽  
L.P. Filaretova
Keyword(s):  
Gastric Mucosa ◽  
Age Dependent

scholarly journals Chloroplast Hsp70 Isoform Is Required for Age-Dependent Tissue Preference of Bamboo mosaic virus in Mature Nicotiana benthamiana Leaves

2017 ◽  
Vol 30 (8) ◽  
pp. 631-645 ◽  
Author(s):  
Ying Wen Huang ◽  
Chung Chi Hu ◽  
Ching Hsiu Tsai ◽  
Na Sheng Lin ◽  
Yau Heiu Hsu
Keyword(s):  
Mosaic Virus ◽  
Nicotiana Benthamiana ◽  
Transit Peptide ◽  
Plant Viruses ◽  
Age Dependent ◽  
Efficient Replication ◽  
Underlying Mechanisms ◽  
Lines Of Evidence ◽  
Suitable Environment

Plant viruses may exhibit age-dependent tissue preference in their hosts but the underlying mechanisms are not well understood. In this study, we provide several lines of evidence to reveal the determining role of a protein of the Nicotiana benthamiana chloroplast Hsp70 (NbcpHsp70) family, NbcpHsp70-2, involved in the preference of Bamboo mosaic virus (BaMV) to infect older tissues. NbcpHsp70 family proteins were identified in complexes pulled down with BaMV replicase as the bait. Among the isoforms of NbcpHsp70, only the specific silencing of NbcpHsp70-2 resulted in the significant decrease of BaMV RNA in N. benthamiana protopalsts, indicating that NbcpHsp70-2 is involved in the efficient replication of BaMV RNA. We further identified the age-dependent import regulation signal contained in the transit peptide of NbcpHsp70-2. Deletion, overexpression, and substitution experiments revealed that the signal in the transit peptide of NbcpHsp70-2 is crucial for both the import of NbcpHsp70-2 into older chloroplasts and the preference of BaMV for infecting older leaves of N. benthamiana. Together, these data demonstrated that BaMV may exploit a cellular age-dependent transportation mechanism to target a suitable environment for viral replication.

Role of prostaglandins of the gastric mucosa in ulcer development in cirrhosis of the liver

1991 ◽  
Vol 112 (6) ◽  
pp. 1721-1724
Author(s):  
R. A. Vysotskaya ◽  
A. S. Loginov ◽  
Z. D. Kondashova
Keyword(s):  
Gastric Mucosa ◽  
Cirrhosis Of The Liver

Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa

1999 ◽  
Vol 14 (10) ◽  
pp. 967-972 ◽  
Author(s):  
Fumihiro Iwata ◽  
Takashi Joh ◽  
Toyohiro Tada ◽  
Noriko Okada ◽  
B Paul Morgan ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Membrane Proteins ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Rat Gastric Mucosa

Role of the unstirred layer in protecting the murine gastric mucosa from bile salt

1986 ◽  
Vol 91 (4) ◽  
pp. 913-918 ◽  
Author(s):  
William C. Duane ◽  
Michael D. Levitt ◽  
Nancy A. Staley ◽  
Ann P. McHale ◽  
Dorothy M. Wiegand ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Bile Salt ◽  
Unstirred Layer

Acetylsalicylic acid hydrolase of gastric mucosa.

1978 ◽  
Vol 234 (6) ◽  
pp. E606
Author(s):  
J G Spenney
Keyword(s):  
Gastric Mucosa ◽  
Enzymatic Activity ◽  
Acetylsalicylic Acid ◽  
Sodium Dodecyl ◽  
Sodium Cholate ◽  
Acid Hydrolase ◽  
Sulfhydryl Reagents ◽  
Ph Optimum ◽  
Diisopropyl Fluorophosphate

Acetylsalicylic acid hydrolase activity of rabbit fundic gastric mucosa has been isolated from the soluble 100,000 X g supernate. The enzymatic activity was partially purified by ammonium sulfate precipitation. The Km for acetylsalicylate was 2 mM and pH optimum was 8.6. The activity was insensitive to ionic strength, slightly inhibited by inclusion of 100 mM Cl-, and demonstrated no requirement for Ca2+ or Mg2+. Acetylsalicylic acid esterase was markedly inhibited by sodium cholate and sodium dodecyl sulfate. The enzyme was insensitive to sulfhydryl reagents with the exception of p-chloromercuribenzenesulfonic acid, which markedly inhibited the enzyme. Diisopropyl fluorophosphate (DFP) inhibited enzymatic activity with a Ki of 9 X 10(-9)M. Eserine was also inhibitory with a Ki of 0.25 mM. Inhibition by DFP at low concentration and by eserine at millimolar concentrations suggests that this enzyme is related to the group of aliphatic esterases. Identification of potent inhibitors will enable studies to define the role of this enzyme with the use of experimental preparations in which systemic toxicity can be avoided.

scholarly journals Limited Role of Bone Marrow Aspiration and Biopsy in the Initial Staging Work-up of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in Korea

Gut and Liver ◽  
2014 ◽  
Vol 8 (6) ◽  
pp. 637-642 ◽  
Author(s):  
Byung-Hoon Min ◽  
Jun Young Park ◽  
Eun Ran Kim ◽  
Yang Won Min ◽  
Jun Haeng Lee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Bone Marrow Aspiration ◽  
Limited Role ◽  
Work Up ◽  
Initial Staging
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