Site-Specific Effects of Intracranial Estradiol Administration on Recurrent Insulin-Induced Hypoglycemia in the Ovariectomized Female Rat

2012 ◽  
Vol 96 (4) ◽  
pp. 311-323 ◽  
Author(s):  
T. Prashant Nedungadi ◽  
Karen P. Briski
Keyword(s):  
Female Rat ◽  
Site Specific ◽  
Specific Effects

scholarly journals Site-specific effects on respiratory rhythm and pattern of ibotenic acid injections in the pontine respiratory group of goats

2010 ◽  
Vol 109 (1) ◽  
pp. 171-188 ◽  
Author(s):  
J. M. Bonis ◽  
S. E. Neumueller ◽  
K. L. Krause ◽  
T. Kiner ◽  
A. Smith ◽  
...  
Keyword(s):  
Pulmonary Ventilation ◽  
Respiratory Rhythm ◽  
Ibotenic Acid ◽  
Pattern Generation ◽  
Respiratory Pattern ◽  
Breathing Patterns ◽  
Site Specific ◽  
Specific Effects ◽  
Tegmental Nuclei ◽  
Pontine Respiratory Group

To probe further the contributions of the rostral pons to eupneic respiratory rhythm and pattern, we tested the hypothesis that ibotenic acid (IA) injections in the pontine respiratory group (PRG) would disrupt eupneic respiratory rhythm and pattern in a site- and state-specific manner. In 15 goats, cannulas were bilaterally implanted into the rostral pontine tegmental nuclei (RPTN; n = 3), the lateral (LPBN; n = 4) or medial parabrachial nuclei (MPBN; n = 4), or the Kölliker-Fuse nucleus (KFN; n = 4). After recovery from surgery, 1- and 10-μl injections (1 wk apart) of IA were made bilaterally through the implanted cannulas during the day. Over the first 5 h after the injections, there were site-specific ventilatory effects, with increased ( P < 0.05) breathing frequency in RPTN-injected goats, increased ( P < 0.05) pulmonary ventilation (V̇i) in LPBN-injected goats, no effect ( P < 0.05) in MPBN-injected goats, and a biphasic V̇i response ( P < 0.05) in KFN-injected goats. This biphasic response consisted of a hyperpnea for 30 min, followed by a prolonged hypopnea and hypoventilation with marked apneas, apneusis-like breathing patterns, and/or shifts in the temporal relationships between inspiratory flow and diaphragm activity. In the awake state, 10–15 h after the 1-μl injections, the number of apneas was greater ( P < 0.05) than during other studies at night. However, there were no incidences of terminal apneas. Breathing rhythm and pattern were normal 22 h after the injections. Subsequent histological analysis revealed that for goats with cannulas implanted into the KFN, there were nearly 50% fewer neurons ( P < 0.05) in all three PRG subnuclei than in control goats. We conclude that in awake goats, 1) IA injections into the PRG have site-specific effects on breathing, and 2) the KFN contributes to eupneic respiratory pattern generation.

scholarly journals MO046NON-ACTIVATABLE MUTANT OF INHIBITOR OF KAPPA B KINASE α (IKKα) EXERTS SITE-SPECIFIC EFFECTS ON ATHEROSCLEROSIS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i48-i48
Author(s):  
Pathricia V. Tilstam ◽  
Wendy Theelen ◽  
Setareh Alampour-Sarabi ◽  
Lukas Pawig ◽  
Yaw Asare ◽  
...  
Keyword(s):  
Site Specific ◽  
Specific Effects

Site-specific effects on productivity of an upper trophic-level marine predator: Bottom-up, top-down, and mismatch effects on reproduction in a colonial seabird

2006 ◽  
Vol 68 (2-4) ◽  
pp. 303-328 ◽  
Author(s):  
Robert M. Suryan ◽  
David B. Irons ◽  
Evelyn D. Brown ◽  
Patrick G.R. Jodice ◽  
Daniel D. Roby
Keyword(s):  
Trophic Level ◽  
Top Down ◽  
Bottom Up ◽  
Site Specific ◽  
Marine Predator ◽  
Specific Effects ◽  
Colonial Seabird

scholarly journals Carbon dioxide ion dissociations after inner shell excitation and ionization: The origin of site-specific effects

2014 ◽  
Vol 140 (18) ◽  
pp. 184305 ◽  
Author(s):  
J. H. D. Eland ◽  
S. Zagorodskikh ◽  
R. J. Squibb ◽  
M. Mucke ◽  
S. L. Sorensen ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Site Specific ◽  
Specific Effects

Analysis of spatial osteochondral heterogeneity in advanced knee osteoarthritis exposes influence of joint alignment

2020 ◽  
Vol 12 (562) ◽  
pp. eaba9481 ◽  
Author(s):  
Sophie Haberkamp ◽  
Tamás Oláh ◽  
Patrick Orth ◽  
Magali Cucchiarini ◽  
Henning Madry
Keyword(s):  
Weight Loss ◽  
Structural Changes ◽  
Scientific Basis ◽  
Strong Correlations ◽  
Varus Knee ◽  
Varus Malalignment ◽  
Compensatory Mechanisms ◽  
Site Specific ◽  
Knee Oa ◽  
Specific Effects

Osteoarthritis (OA) is considerably affected by joint alignment. Here, we investigate the patterns of spatial osteochondral heterogeneity in patients with advanced varus knee OA together with clinical data. We report strong correlations of osteochondral parameters within individual topographical patterns, highlighting their fundamental and location-dependent interactions in OA. We further identify site-specific effects of varus malalignment on the lesser loaded compartment and, conversely, an unresponsive overloaded compartment. Last, we trace compensatory mechanisms to the overloaded subarticular spongiosa in patients with additional high body weight. We therefore propose to consider and to determine axial alignment in clinical trials when selecting the location to assess structural changes in OA. Together, these findings broaden the scientific basis of therapeutic load redistribution and weight loss in varus knee OA.

scholarly journals Site-specific effects of 17β-estradiol in hornyhead turbot (Pleuronichthys verticalis) collected from a wastewater outfall and reference location

2009 ◽  
Vol 109 (5) ◽  
pp. 552-558 ◽  
Author(s):  
Mary Ann Rempel-Hester ◽  
Haizheng Hong ◽  
Yinsheng Wang ◽  
Xin Deng ◽  
Jeff Armstrong ◽  
...  
Keyword(s):  
Site Specific ◽  
Reference Location ◽  
Specific Effects ◽  
17Β Estradiol ◽  
Wastewater Outfall ◽  
Pleuronichthys Verticalis
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