Molecular Mechanisms of Muscle Stem Cell Aging

2012 ◽  
pp. 100-111
Author(s):  
Ali Hyder Baig ◽  
Stefan Tümpel
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Cell Aging ◽  
Muscle Stem Cell ◽  
Stem Cell Aging

scholarly journals Muscle stem cell aging: identifying ways to induce tissue rejuvenation

2020 ◽  
Vol 188 ◽  
pp. 111246
Author(s):  
Pedro Sousa-Victor ◽  
Joana Neves ◽  
Pura Muñoz-Cánoves
Keyword(s):  
Stem Cell ◽  
Cell Aging ◽  
Muscle Stem Cell ◽  
Stem Cell Aging

scholarly journals The ins and outs of muscle stem cell aging

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Andrew S. Brack ◽  
Pura Muñoz-Cánoves
Keyword(s):  
Stem Cell ◽  
Cell Aging ◽  
Muscle Stem Cell ◽  
Stem Cell Aging

scholarly journals Molecular Mechanisms of Stem Cell Aging

2019 ◽  
Vol 56 (1) ◽  
Author(s):  
Katerina Jazbec ◽  
Mojca Jež ◽  
Mojca Justin ◽  
Primož Rožman
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Cell Aging ◽  
Stem Cell Aging

scholarly journals Aging of hematopoietic stem cells

Blood ◽  
2018 ◽  
Vol 131 (5) ◽  
pp. 479-487 ◽  
Author(s):  
Gerald de Haan ◽  
Seka Simone Lazare
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Blood Cells ◽  
Aging Process ◽  
Molecular Mechanisms ◽  
Cell Aging ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Aging

Abstract Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. We argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. Because many hematological pathologies are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.

Muscle stem cell aging: regulation and rejuvenation

2015 ◽  
Vol 26 (6) ◽  
pp. 287-296 ◽  
Author(s):  
Pedro Sousa-Victor ◽  
Laura García-Prat ◽  
Antonio L. Serrano ◽  
Eusebio Perdiguero ◽  
Pura Muñoz-Cánoves
Keyword(s):  
Stem Cell ◽  
Cell Aging ◽  
Muscle Stem Cell ◽  
Stem Cell Aging

scholarly journals The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Pei Zhu ◽  
Chunping Zhang ◽  
Yongxing Gao ◽  
Furen Wu ◽  
Yalu Zhou ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Aging ◽  
Muscle Stem Cell ◽  
Stem Cell Aging

scholarly journals The Mechanism of Stem Cell Aging

2022 ◽  
Author(s):  
Liangyu Mi ◽  
Junping Hu ◽  
Na Li ◽  
Jinfang Gao ◽  
Rongxiu Huo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Cell Aging ◽  
Therapeutic Application ◽  
Differentiation Potential ◽  
Stem Cell Aging ◽  
New Directions ◽  
Aging Mechanisms

AbstractStem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, revealing the molecular mechanisms of stem cell aging will set new directions for the therapeutic application of stem cells, the study of aging mechanisms, and the prevention and treatment of aging-related diseases. This review comprehensively describes the molecular mechanisms related to stem cell aging and provides the basis for further investigations aimed at developing new anti-stem cell aging strategies and promoting the clinical application of stem cells.

Sign in / Sign up

Export Citation Format

Share Document