Gender Influences Short-Term Growth Hormone Treatment Response in Children

2012 ◽  
Vol 77 (3) ◽  
pp. 188-194 ◽  
Author(s):  
Lars Sävendahl ◽  
Oliver Blankenstein ◽  
Isabelle Oliver ◽  
Henrik Thybo Christesen ◽  
Peter Lee ◽  
...  
2017 ◽  
Vol 187 (3) ◽  
pp. 553-569 ◽  
Author(s):  
Peggy Stock ◽  
Maximilian Bielohuby ◽  
Martin S. Staege ◽  
Mei-Ju Hsu ◽  
Martin Bidlingmaier ◽  
...  

2021 ◽  
Vol 50 (1) ◽  
pp. 47-56
Author(s):  
Katarina Božić ◽  
Tatjana Milenković ◽  
Srđan Pašić ◽  
Katarina Mitrović ◽  
Slađana Todorović ◽  
...  

Introduction/Aim: Spondylodysplastic Ehlers-Danlos Syndrome (sdEDS) is a rare genetic disorder of collagen synthesis, caused by a mutation in the B4GALT7, B3GALT6, or SLC39A13 gene. Features of this very rare disorder are short stature, hypotonia, hyperflexible joints, soft, thin, and overly stretchable skin, sparse hair and eyebrows, elderly face, wide forehead and prolonged wound healing. Molecular genetic analysis is needed for definite confirmation of the diagnosis. So far, only three case reports describing growth hormone treatment response in patients with sdEDS have been published. All of these patients had growth hormone (GH) deficiency. We present the first case report regarding growth hormone treatment response in a patient with sdEDS and normal GH secretion (without GH deficiency). Case report: Patient was a girl with short stature and normal GH secretion. Having in mind that the girl was born small for the gestational age, due to her short stature, she started using HR, before the diagnosis of sdEDS was made. Based on the lack of improvement in growth velocity as well as the girl's phenotype, genetic analyses were performed and the diagnosis of sdEDS due to biallelic mutations of the B4GALT7 gene was established. After the diagnosis of sdEDS was made and due to suboptimal response in growth velocity to the GH treatment, the GH therapy was stopped at the age of 11 years. Conclusion: This is a first case report regarding GH treatment in a child with sdEDS and normal GH secretion, demonstrating a very limited therapeutic effect of GH on linear growth in the presented patient.


2000 ◽  
Vol 151 (1) ◽  
pp. 205
Author(s):  
S. Coşkun ◽  
B. Ersoy ◽  
C. Şekuri ◽  
K. Özbilgin ◽  
M. Yurtseven ◽  
...  

2009 ◽  
Vol 78 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Richard Nissel ◽  
Dagmar-Christiane Fischer ◽  
Andreas Puhlmann ◽  
Birgit Holdt-Lehmann ◽  
Andrea Mitzner ◽  
...  

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