Simultaneous Determination of a Novel Diphenylpiperazine Calcium Channel Blocker and Its Four Metabolites in Rat Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry

Pharmacology ◽  
2012 ◽  
Vol 89 (3-4) ◽  
pp. 201-210 ◽  
Author(s):  
Wei Guo ◽  
Dezhi Kong ◽  
Yingfeng Du ◽  
Xiaowei Shi ◽  
Wei Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Channel Blocker ◽  
Liver Microsomes ◽  
Tandem Mass ◽  
Rat Liver Microsomes ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Validated assay for the evaluation of multiple glucuronidation activities in human liver microsomes via liquid chromatography-tandem mass spectrometry

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56132-56138 ◽  
Author(s):  
Rong Shi ◽  
Yuanyuan Yang ◽  
Jie Zhong ◽  
Tianming Wang ◽  
Yueming Ma
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Human Liver ◽  
Liver Microsomes ◽  
Tandem Mass ◽  
Activity Determination ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

A faster and more accurate LC-MS/MS method was established for the activity determination of multiple UGT isoforms in HLMs.

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