scholarly journals Unusual Presentation of Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Mimicking Poorly Differentiated Gastric Adenocarcinoma

2012 ◽  
Vol 6 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Yutaka Tomizawa ◽  
Michiharu Seki ◽  
Masaya Mori
Keyword(s):  
Gastric Mucosa ◽  
Gastric Adenocarcinoma ◽  
Lymphoid Tissue ◽  
Unusual Presentation ◽  
Poorly Differentiated

scholarly journals A Case Report of Synchronous Early Gastric Adenocarcinoma and Gastric Mucosa Associated with a Lymphoid Tissue Lymphoma

2013 ◽  
Vol 74 (6) ◽  
pp. 1523-1528
Author(s):  
Hiroki ARAI ◽  
Takeshi MATSUTANI ◽  
Hiroshi YOSHIDA ◽  
Koji SASAJIMA ◽  
Eiji UCHIDA
Keyword(s):  
Case Report ◽  
Gastric Mucosa ◽  
Gastric Adenocarcinoma ◽  
Lymphoid Tissue

Premalignant gastric lesions in patients with gastric mucosa-associated lymphoid tissue lymphoma and metachronous gastric adenocarcinoma

2012 ◽  
Vol 24 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Lisette G. Capelle ◽  
Caroline M. den Hoed ◽  
Annemarie C. de Vries ◽  
Katharina Biermann ◽  
Mariel K. Casparie ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Gastric Adenocarcinoma ◽  
Lymphoid Tissue ◽  
Gastric Lesions

Unusual presentation of multiple pathologic bone fractures in a patient with gastric mucosa-associated lymphoid tissue lymphoma

2009 ◽  
Vol 89 (4) ◽  
pp. 431-436 ◽  
Author(s):  
Sung-Hsin Kuo ◽  
Ruoh-Fang Yen ◽  
Chung-Wu Lin ◽  
Li-Tzong Chen ◽  
Hwei-Fang Tien ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Bone Fractures ◽  
Unusual Presentation

HER2 OVEREXPRESSION IN ENDOSCOPIC BIOPSY SAMPLE OF GASTRIC ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY

2012 ◽  
pp. 109-118
Author(s):  
Viet Nho Le ◽  
Van Huy Tran ◽  
Cong Thuan Dang ◽  
Van To Ta
Keyword(s):  
Gastric Adenocarcinoma ◽  
Undifferentiated Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Endoscopic Biopsy ◽  
Her2 Overexpression ◽  
Tubular Adenocarcinoma ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Well Differentiated

Background and aim: HER2 overexpression by immunohistochemistry is a prognostic maker in gastric cancer and helps to select candidates benefitted from targeted therapy with trastuzumab. This study is aimed at the assessing HER2 overexpression and its relationship with endoscopic and histopathological findings of gastric adenocarcinoma. Objectives and methods: Biopsy samples from 92 gastric cancer patients were examined for HER2 status by immunohistochemical staining. Results: 6.5% of tumors were cardia tumors and 93.5% were non-cardia tumors. Using the Lauren classification, 51.1% were intestinal type and 48.9% were diffuse type. Using WHO classification, 54.3% were tubular adenocarcinoma, 7.6% were mucinous adenocarcinoma, 15.2% were signet-ring cell carcinoma, and 22.8% were undifferentiated carcinoma. 32.6% were well-differentiated, 15.2% were moderately-differentiated, and 52.2% were poorly-differentiated carcinoma. HER2 was positive in 20.7% of gastric carcinomas, 50% cardia tumors and 18.6% non-cardia tumors. HER2 positivity among polypoid, fungating, ulcerated, and infiltrative types were 38.5%, 29.7%, 9.1% and 0%, respectively. HER2 overexpression in intestinal type was higher than that in diffuse type (31.9% vs. 8.9%, p = 0.009). HER2 overexpression in tubular adenocarcinoma, mucinous adenocarcinoma, signet-ring cell carcinoma, and undifferentiated carcinoma was 28.0%, 14.3%, 7.1% and 14.3%, respectively. HER2 overexpressions were different between differentiation degrees: 30% of well-differentiated tumors, 35.7% moderately-differentiated tumors, and 10.4% of poorly-differentiated tumors (p = 0.037). Conclusions: HER2 overexpression was found in 20.7% of endoscopic biopsy sample of gastric adenocarcinoma and was associated with endoscopic gross characteristic, Lauren histologic type and differentiation degree.

scholarly journals Genetic Characterization and Clinical Features of Helicobacter pylori Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2993
Author(s):  
Barbara Kiesewetter ◽  
Christiane Copie-Bergman ◽  
Michael Levy ◽  
Fangtian Wu ◽  
Jehan Dupuis ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Signaling Pathways ◽  
Clinical Features ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Targeted Sequencing ◽  
Clinicopathological Parameters ◽  
Gastric Malt Lymphoma ◽  
Genetic Changes ◽  
H Pylori

Background: In Western countries, the prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma has declined over the last three decades. Contemporaneously, H. pylori negative gastric MALT lymphoma is increasingly encountered, and their genetic basis and clinical features remain elusive. Methods: A total of 57 cases of H. pylori negative gastric MALT lymphoma were reviewed and investigated for chromosome translocation by fluorescence in-situ hybridization and for somatic mutations by the targeted sequencing of 93 genes. Results: MALT1 translocation, most likely t(11;18)(q21;q21)/BIRC3-MALT1, was detected in 39% (22/57) cases, and IGH translocation was further seen in 12 MALT1-negative cases, together accounting for 60% of the cohort. Targeted sequencing was successful in 35 cases, and showed frequent mutations in NF-κB signaling pathways (TNFAIP3 = 23%, CARD11 = 9%, MAP3K14 = 9%), together affecting 14 cases (40%). The NF-κB pathway mutations were mutually exclusive from MALT1, albeit not IGH translocation, altogether occurring in 86% of cases. There was no significant correlation between the genetic changes and clinicopathological parameters. The patients showed a median of progression-free survival (PFS) of 66.3 months, and a significant superior PFS when treated with systemic versus antibiotic therapy (p = 0.004). Conclusion: H. pylori negative gastric MALT lymphoma is characterized by highly frequent genetic changes in the NF-κB signaling pathways.

Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma

2017 ◽  
Vol 58 (9) ◽  
pp. 2057-2064 ◽  
Author(s):  
Aurelien Amiot ◽  
Valerie Jooste ◽  
Charlotte Gagniere ◽  
Michaël Lévy ◽  
Christiane Copie-Bergman ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Second Primary ◽  
Second Primary Malignancies

Bone marrow involvement is rare in superficial gastric mucosa-associated lymphoid tissue lymphoma

2016 ◽  
Vol 48 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Jae Yong Park ◽  
Sang Gyun Kim ◽  
Joo Sung Kim ◽  
Hyun Chae Jung
Keyword(s):  
Bone Marrow ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Bone Marrow Involvement
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