Vitamin E Alters Inflammatory Gene Expression in Alcoholic Chronic Pancreatitis

2012 ◽  
Vol 5 (2) ◽  
pp. 94-105 ◽  
Author(s):  
Thaís Helena Monteiro ◽  
Camila Siqueira Silva ◽  
Livia Maria Cordeiro Simões Ambrosio ◽  
Sergio Zucoloto ◽  
Helio Vannucchi
Keyword(s):  
Gene Expression ◽  
Chronic Pancreatitis ◽  
Vitamin E ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Alcoholic Chronic Pancreatitis

scholarly journals The Effects of Antioxidant Supplements on the Inflammatory Gene Expression of Osteoarthritis-Like Chondrocytes

2020 ◽  
Vol 11 (1) ◽  
pp. 239
Author(s):  
Chen-Ying Su ◽  
Yongxiang Luo ◽  
Chi-Hau Fang ◽  
Hsu-Wei Fang
Keyword(s):  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Vitamin E ◽  
Cell Viability ◽  
Combined Treatment ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Tnf Α ◽  
Osteoarthritis Treatment ◽  
Antioxidant Supplements

Osteoarthritis patients often experience pain and inflammation in joints. To understand whether antioxidant supplements could reduce inflammation and could potentially be applied for osteoarthritis treatment, vitamin E and resveratrol were investigated in this study. Hydrogen peroxide was used for inducing inflammation in porcine chondrocytes, and the lumen density was measured for the level of oxygen-derived free radicals. In total, 5, 50, 100, and 200 μM of vitamin E and resveratrol were analyzed for cell viability and the effect of lumen density. In addition, the expressions of IL-1β, TNF-α, MMP-1, MMP-13, and COL2A1 were investigated when treating chondrocytes with 100 μM vitamin E, 5 μM resveratrol, or their combination before or after hydrogen peroxide induction. Inducing chondrocytes with hydrogen peroxide for 30 min increased the level of lumen density sufficiently and stimulated the expression of inflammatory genes. All the concentrations of vitamin E and resveratrol showed good cell viability. Single treatment with either vitamin E or resveratrol reduced inflammatory gene expression, and combined treatment increased the expression of collagen type II. The results suggested that post-treatment with both vitamin E and resveratrol has a better effect on the reduction in inflammation in osteoarthritis-like chondrocytes.

Dysregulation of inflammatory gene expression in lesional and nonlesional skin of patients with pyoderma gangrenosum

2017 ◽  
Vol 178 (1) ◽  
Author(s):  
A.G. Ortega‐Loayza ◽  
W.H. Nugent ◽  
O.M. Lucero ◽  
S.L. Washington ◽  
J.R. Nunley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pyoderma Gangrenosum ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene

scholarly journals Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Diego Guerrieri ◽  
Luis Re ◽  
Jorgelina Petroni ◽  
Nella Ambrosi ◽  
Roxana E. Pilotti ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Factors ◽  
Kidney Transplantation ◽  
Inflammatory Markers ◽  
Graft Function ◽  
Deceased Donor ◽  
Specific Pattern ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Recipient Age

Background.Delayed graft function (DGF) remains an important problem after kidney transplantation and reduced long-term graft survival of the transplanted organ. The aim of the present study was to determine if the development of DGF was associated with a specific pattern of inflammatory gene expression in expanded criteria of deceased donor kidney transplantation. Also, we explored the presence of correlations between DGF risk factors and the profile that was found.Methods.Seven days after kidney transplant, a cDNA microarray was performed on biopsies of graft from patients with and without DGF. Data was confirmed by real-time PCR. Correlations were performed between inflammatory gene expression and clinical risk factors.Results.From a total of 84 genes analyzed, 58 genes were upregulated while only 1 gene was downregulated in patients with DGF compared with no DGF (P=0.01). The most relevant genes fold changes observed was IFNA1, IL-10, IL-1F7, IL-1R1, HMOX-1, and TGF-β. The results were confirmed for IFNA1, IL-1R1, HMOX-1 and TGF-β. A correlation was observed between TGF-β, donor age, and preablation creatinine, but not body mass index (BMI). Also, TGF-βshowed an association with recipient age, while IFNA1 correlated with recipient BMI. Furthermore, TGF-β, IFNA1 and HMOX-1 correlated with several posttransplant kidney function markers, such as diuresis, ultrasound Doppler, and glycemia.Conclusions.Overall, the present study shows that DGF is associated with inflammatory markers, which are correlated with donor and recipient DGF risk factors.

Manganese modulates pro-inflammatory gene expression in activated glia

2006 ◽  
Vol 49 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Chun-Jung Chen ◽  
Yen-Chuan Ou ◽  
Shih-Yi Lin ◽  
Su-Lan Liao ◽  
Shih-Yun Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene
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