Breast Cancers Detected by Breast MRI Screening and Ultrasound in Asymptomatic Asian Women: 8 Years of Experience in Taiwan

Oncology ◽  
2012 ◽  
Vol 82 (2) ◽  
pp. 98-107 ◽  
Author(s):  
Yu-Chen Cheng ◽  
Nai-Yuan Wu ◽  
James S. Ko ◽  
Po-Wei Lin ◽  
Wei-Chan Lin ◽  
...  
Author(s):  
Col (Dr.) Puneet Takkar ◽  
◽  
Surg Lt Cdr (Dr.) Hari JP ◽  
Surg Lt Cdr (Dr.) Khushdeep Kaur ◽  
◽  
...  

2019 ◽  
Vol 58 ◽  
pp. 84-89 ◽  
Author(s):  
Amy N. Melsaether ◽  
Eric Kim ◽  
Eralda Mema ◽  
James Babb ◽  
Sungheon Gene Kim

2011 ◽  
Vol 77 (10) ◽  
pp. 1361-1363 ◽  
Author(s):  
Lindi H. Vanderwalde ◽  
Catherine M. Dang ◽  
Catherine Bresee ◽  
Edward H. Phillips

Preoperative breast MRI does not decrease re-excision rates in patients who undergo lumpectomy. We evaluated concordance of tumor size on MRI and pathologic size in patients who underwent re-excision of margins after lumpectomy. A retrospective review of patients at the Cedars-Sinai Breast Center who received breast MRI was performed. We found that MRI was performed before lumpectomy in 136 patients. Mean age was 55.2 years (standard deviation ± 12.6). Re-excision occurred in 34 per cent (n = 46). Of those undergoing re-excision, 35 per cent (16/46) were re-excised for ductal carcinoma in situ (DCIS) at the lumpectomy margin. There was no significant difference between radiologic and pathologic size of the tumor (1.94 vs 2.12 cm; P = 0.159). In those who underwent re-excision, the radiologic size was underestimated compared with the pathologic size (2.01 vs 2.66 cm; P = 0.032). Patients with pure DCIS lesions (n = 9) also had smaller radiologic tumor size compared with pathologic (0.64 vs 2.88 cm; P = 0.039), and this difference trended toward significance in those who underwent re-excision (0.55 vs 3.50 cm; P = 0.059). Discordance between tumor size on MRI and pathologic size may contribute to re-excisions in patients who undergo lumpectomy. The limitations of breast MRI to evaluate the extent of DCIS surrounding many breast cancers, and the impact on re-excision rates, should be further evaluated.


2019 ◽  
Vol 5 (3) ◽  
pp. 20190026
Author(s):  
Oshaani Abeyakoon ◽  
Arash Latifoltojar ◽  
Fiona Gong ◽  
Marianthi-Vasiliki Papoutsaki ◽  
Rafat Chowdhury ◽  
...  

Hyperpolarised 13C MRI (HP-MRI) is a novel imaging technique that allows real-time analysis of metabolic pathways in vivo. 1 The technology to conduct HP-MRI in humans has recently become available and is starting to be clinically applied. As knowledge of molecular biology advances, it is increasingly apparent that cancer cell metabolism is related to disease outcomes, with lactate attracting specific attention. 2 Recent reviews of breast cancer screening programs have raised concerns and increased public awareness of over treatment. The scientific community needs to shift focus from improving cancer detection alone to pursuing novel methods of distinguishing aggressive breast cancers from those which will remain indolent. HP-MRI offers the opportunity to identify aggressive tumour phenotypes and help monitor/predict therapeutic response. Here we report one of the first cases of breast cancer imaged using HP-MRI alongside correlative conventional imaging, including breast MRI.


2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 58-58
Author(s):  
Christiane K. Kuhl ◽  
Heribert Bieling ◽  
Kevin Strobel ◽  
Eva Wardelmann ◽  
Walter Kuhn ◽  
...  

58 Background: DCIS-components of invasive breast-cancers are a major cause for positive margins and reoperations in women undergoing breast-conserving-surgery. We investigated whether breast-MRI, through improved diagnosis of such DCIS-components, combined with MR-guided needle biopsy and pre-operative MR-guided lesion bracketing where appropriate, would help reduce reoperation-rates for invasive breast cancers. Our hypothesis was that with improved diagnosis of local disease extent through MRI and MR-guided surgery, reoperation rates should be low, and should be independent of the presence or absence of a DCIS-component. Methods: Prospective study in two academic breast-centers on consecutive patients with newly-diagnosed invasive breast-cancer. Women underwent breast-MRI in addition to conventional imaging (CI; digital-mammography/breast-ultrasound), and MR-guided needle-biopsy and preoperative MR-guided lesion bracketing where appropriate. Accuracy of breast-MRI for diagnosing DCIS-components was compared with that of CI, stratified by nuclear-grade and relative size of DCIS-components. Surgical outcomes (reoperation and mastectomy-rates) were recorded, stratified by presence or absence of DCIS-components. Results: 593 women were included. Surgical-pathology documented DCIS-components in 139/593 (23.4%) women. Sensitivity of MRI (84.9%) for demonstrating DCIS-components was significantly higher than that of CI (36.7%) (p < 0.0001); over half (51.1%) of DCIS-components were only detected by MRI. The sensitivity advantage of MRI over CI increased significantly with increasing relative size and nuclear-grade of the DCIS-component. Reoperation-rates were equivalent for women with vs. without DCIS-components (10.1% vs. 9.9%); mastectomy rates were 10.8% and 8.1%, respectively. Similar Positive-Predictive-Values were achieved with CI and MRI. Conclusions: Breast-MRI significantly improves depiction of DCIS-components of invasive breast-cancers prior to surgery. Use of breast-MRI and MR-guided surgery translates into low reoperation rates for women with operable invasive breast-cancer, which were similar for women with or without DCIS-components.


2018 ◽  
Vol 92 ◽  
pp. S143
Author(s):  
Y.S. Yap ◽  
A. Singh ◽  
J.H.C. Lim ◽  
J.H. Ahn ◽  
K.H. Jung ◽  
...  

2015 ◽  
Vol 33 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Ji Youn Kim ◽  
Sung Hun Kim ◽  
Yun Ju Kim ◽  
Bong Joo Kang ◽  
Yeong Yi An ◽  
...  

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