Short-Chain Fatty Acids Induce Apoptosis in Colon Cancer Cells Associated with Changes to Intracellular Redox State and Glucose Metabolism

Chemotherapy ◽  
2012 ◽  
Vol 58 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Geoffrey M. Matthews ◽  
Gordon S. Howarth ◽  
Ross N. Butler
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Glucose Metabolism ◽  
Cancer Cells ◽  
Redox State ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Colon Cancer Cells ◽  
Chain Fatty Acids ◽  
Intracellular Redox

Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells

1998 ◽  
Vol 275 (1) ◽  
pp. G85-G94 ◽  
Author(s):  
Chau P. Tran ◽  
Mary Familari ◽  
Lorraine M. Parker ◽  
Robert H. Whitehead ◽  
Andrew S. Giraud
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Trefoil Factor ◽  
Colon Cancer Cells ◽  
Intestinal Trefoil Factor ◽  
Response Element

Intestinal trefoil factor (ITF) gene expression was detected in five colon cancer cell lines. ITF was synthesized by mucous cells of LIM 1215 and LIM 1863 lines, from which it is secreted constitutively. The ITF mRNA transcript was estimated to be 0.6 kb. In LIM 1215 cells, the expression of ITF was potently and dose-dependently inhibited by short-chain fatty acids (butyrate > propionate > acetate) within 8 h of application. The inhibitory effect of butyrate was ablated by actinomycin D and preceded its effects on differentiation of LIM 1215 cells as indicated by induction of alkaline phosphatase activity and counting of periodic acid-Schiff-positive cells. The human ITF promoter contained an 11-residue consensus sequence with high homology to the butyrate response element of the cyclin D1 gene. Mobility shift assays show specific binding of this response element to nuclear protein extracts of LIM 1215 cells. We conclude that butyrate inhibits ITF expression in colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation.

A proteomic analysis of differential cellular responses to the short-chain fatty acids butyrate, valerate and propionate in colon epithelial cancer cells

2012 ◽  
Vol 8 (4) ◽  
pp. 1146-1156 ◽  
Author(s):  
Josephine Kilner ◽  
Jennifer S. Waby ◽  
Joanna Chowdry ◽  
Abdul Q. Khan ◽  
Josselin Noirel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cancer Cells ◽  
Proteomic Analysis ◽  
Cellular Responses ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Epithelial Cancer ◽  
Chain Fatty Acids

scholarly journals Short Chain Fatty Acids and Colon Cancer

2002 ◽  
Vol 132 (12) ◽  
pp. 3804S-3808S ◽  
Author(s):  
Leonard H. Augenlicht ◽  
John M. Mariadason ◽  
Andrew Wilson ◽  
Diego Arango ◽  
WanCai Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids
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