scholarly journals Tracking of Leptin, Soluble Leptin Receptor, and the Free Leptin Index during Weight Loss and Regain in Children

Obesity Facts ◽  
2011 ◽  
Vol 4 (6) ◽  
pp. 461-468 ◽  
Author(s):  
Jens-Christian Holm ◽  
Michael Gamborg ◽  
Leigh C. Ward ◽  
Steen Gammeltoft ◽  
Karsten Kaas-Ibsen ◽  
...  
Keyword(s):  
Weight Loss ◽  
Leptin Receptor ◽  
Soluble Leptin Receptor

Weight Loss Increases Soluble Leptin Receptor Levels and the Soluble Receptor Bound Fraction of Leptin

2002 ◽  
Vol 10 (7) ◽  
pp. 597-601 ◽  
Author(s):  
Markus Laimer ◽  
Christoph F. Ebenbichler ◽  
Susanne Kaser ◽  
Anton Sandhofer ◽  
Helmut Weiss ◽  
...  
Keyword(s):  
Weight Loss ◽  
Leptin Receptor ◽  
Soluble Receptor ◽  
Soluble Leptin Receptor

scholarly journals Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Beata Kulik-Rechberger ◽  
Anna Maria Bury ◽  
Anna Rakuś-Kwiatosz ◽  
Iwona Beń-Skowronek
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Birth Weight ◽  
Negative Correlation ◽  
Leptin Receptor ◽  
Later Life ◽  
Study Group ◽  
Soluble Leptin Receptor ◽  
Term Newborns ◽  
Positive Correlations

Abstract Background Birth weight and leptin seem to be the factors responsible for early programming of body weight in later life. A marker for leptin action is free leptin index (FLI), which depends on soluble leptin receptor (Ob-Re) (FLI = leptin/Ob-Re). In the present article, we suggest that FLI is modulated partly by cortisol variations observed in newborns in the first days of life and is connected with their postnatal weight loss. Methods The study group consisted of 44 full-term newborns. Leptin, cortisol and Ob-Re concentrations were determined in the umbilical cord blood (UCB) and in the newborns’ blood (NB) on the fourth day of life, free leptin index (FLI = leptin/Ob-Re) was calculated. Correlations between the assessed parameters and the somatic features of the newborns were examined. Results Birth weight, length and chest circumference of newborns were positively correlated with leptin concentration in the UCB but not with FLI in the UCB. Cortisol and leptin concentrations, as well as FLI values declined concomitantly with body weight, and were lower on the fourth day of life than on the first one; however, Ob-Re concentration increased (p < 0.0001). There was a positive correlation between the newborns’ birth weight loss percentage evaluated on the fourth day of life and FLI in newborns (R = 0.39; p < 0.01). Positive correlations between cortisol and Ob-Re in UCB (R = 0.35; p < 0.02) and in NB (R = 0.36; p < 0.01), as well as a negative correlation between cortisol and FLI (R = -0.32; p < 0.03) in NB were noted. Conclusions Our data suggest a possible relationship between cortisol and a soluble leptin receptor (Ob-Re), which changes free leptin index (FLI) and is connected with birth weight loss in newborns. Whether these observations are important for programming of future body weight of children requires further research.

Effect of valproic acid treatment on body composition, leptin and soluble leptin receptor in epileptic children

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
M Rauchenzauner ◽  
E Haberlandt ◽  
S Scholl-Bürgi ◽  
D Karall ◽  
E Schönherr ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Body Composition ◽  
Acid Treatment ◽  
Leptin Receptor ◽  
Soluble Leptin Receptor ◽  
Epileptic Children

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

2018 ◽  
Author(s):  
Clément K ◽  
Biebermann H ◽  
Farooqi IS ◽  
Van der Ploeg L ◽  
Wolters B ◽  
...  
Keyword(s):  
Weight Loss ◽  
Leptin Receptor

Effects of Dexamethasone Administration on Free Leptin, Bound Leptin and Soluble Leptin Receptor

1999 ◽  
Vol 96 (s40) ◽  
pp. 1P-1P
Author(s):  
K Lewandowski ◽  
H Randeva ◽  
E Hillhouse ◽  
G Brabant ◽  
P O'Hare
Keyword(s):  
Leptin Receptor ◽  
Soluble Leptin Receptor
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