Phosphorylation of ERK1/2 in Dorsal Root Ganglia following Sequential Mustard Oil and Thermal Stimulation of the Rat Hind Paw

Pharmacology ◽  
2012 ◽  
Vol 89 (1-2) ◽  
pp. 7-12 ◽  
Author(s):  
Josef Donnerer ◽  
Ingrid Liebmann
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Thermal Stimulation ◽  
Mustard Oil ◽  
Stimulation Of

Stimulation of Dorsal Root Ganglia for the Management of Complex Regional Pain Syndrome: A Prospective Case Series

Pain Practice ◽  
2014 ◽  
Vol 15 (3) ◽  
pp. 208-216 ◽  
Author(s):  
Jean-Pierre Van Buyten ◽  
Iris Smet ◽  
Liong Liem ◽  
Marc Russo ◽  
Frank Huygen
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Case Series ◽  
Pain Syndrome ◽  
Prospective Case Series ◽  
Stimulation Of

Dorsal root ganglia grafts stimulate regeneration of denervated urodele forelimbs: timing of graft implantation with respect to denervation

Development ◽  
1987 ◽  
Vol 99 (2) ◽  
pp. 173-186
Author(s):  
B.L. Tomlinson ◽  
R.A. Tassava
Keyword(s):  
Cell Cycle ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Relative Number ◽  
Blastema Cell ◽  
Neurotrophic Activity ◽  
Adult Newt ◽  
Timing Strategies ◽  
Graft Implantation ◽  
Stimulation Of

Amphibian forelimb regeneration is a nerve-dependent process; nerves presumably release one or more neurotrophic factors that stimulate blastema cell division. To date several candidate molecules/factors have been shown to stimulate macromolecular synthesis and/or mitosis but sustained cell cycle activity and blastema development have not been achieved. Because dorsal root ganglia (DRG) implants are capable of promoting regeneration of denervated adult newt limbs (Kamrin & Singer, 1959), we have evaluated the DRG stimulation of regeneration in denervated limbs of adult newts and larval axolotls; two alternative timing strategies were tested as a step toward defining bioassay parameters that best reflect neurotrophic activity. The frequency of regeneration in denervated adult newt limbs was compared after providing DRG before or at the time of denervation (to maintain neurotrophic and cell cycle activity) versus DRG implantation at various postdenervation times (to resupply neurotrophic activity and restimulate suppressed cell cycle activity). The results show that denervated adult newt limbs regenerated most frequently using the maintenance strategy, but as the denervation interval was extended in the restimulation strategy, the frequency of regeneration declined. Larval axolotl limbs responded positively in both maintenance and restimulation DRG-grafting protocols. These results suggest that the efficacy of DRG stimulation of regeneration in adult newts was related to the relative number of blastema cells present at the time of denervation and the proliferative status of the blastema cells; bioassays with denervated adult newt limbs should be designed with these constraints in mind. Because such constraints are not as problematic with the larval axolotl, this species may provide the best opportunity for further defining bioassay parameters related to the neurotrophic stimulation of regeneration.

Mechanical Stimulation of Dorsal Root Ganglia Induces Increased Production of Substance P: A Mechanism for Pain Following Nerve Root Compromise?

Spine ◽  
1987 ◽  
Vol 12 (6) ◽  
pp. 552-555 ◽  
Author(s):  
MARIE A. BADALAMENTE ◽  
ROGER DEE ◽  
RICHARD GHILLANI ◽  
PU-FAN CHIEN ◽  
KENNEDY DANIELS
Keyword(s):  
Substance P ◽  
Dorsal Root Ganglia ◽  
Mechanical Stimulation ◽  
Nerve Root ◽  
Dorsal Root ◽  
Stimulation Of

Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back

Pain Practice ◽  
2017 ◽  
Vol 18 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Frank Huygen ◽  
Liong Liem ◽  
William Cusack ◽  
Jeffery Kramer
Keyword(s):  
Pain Relief ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Low Back ◽  
Effective Pain Relief ◽  
Stimulation Of

scholarly journals Electroacupuncture and Moxibustion Modulate the BDNF and TrkB Expression in the Colon and Dorsal Root Ganglia of IBS Rats with Visceral Hypersensitivity

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Duiyin Jin ◽  
Yanan Liu ◽  
Siyi Lv ◽  
Qin Qi ◽  
Mei Li ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
The Body ◽  
Visceral Hypersensitivity ◽  
Mustard Oil ◽  
Rat Colon ◽  
Tyrosine Kinase Receptor ◽  
Once Daily ◽  
Mild Moxibustion ◽  
Pinaverium Bromide

Objective. To evaluate the effects of electroacupuncture and moxibustion on brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptor B (TrkB) protein and mRNA expressions in the colon and dorsal root ganglia of IBS rats with visceral hypersensitivity and to explore their underlying therapeutic mechanisms. Method. Forty Sprague Dawley rats were randomly divided into normal, model, model + mild moxibustion (MM), model + electroacupuncture (EA), and model + pinaverium bromide (PB) groups, with eight rats in each group. Chronic visceral hypersensitive IBS rat models were established by colorectal distension (CRD) with mustard oil clyster. Rats in the MM and EA groups, respectively, received moxibustion and electroacupuncture treatments on the Tianshu (ST25) and Shangjuxu (ST37) acupoints once daily for 7 days, and rats in the PB group received pinaverium bromide by oral gavage once daily for 7 consecutive days. After treatment, rats underwent abdominal withdrawal reflex (AWR) scoring under CRD and colon histopathological examination. Immunohistochemistry and real-time quantitative PCR (RT-qPCR) were used to study the protein and mRNA expressions of BDNF and TrkB in the rat colon and dorsal root ganglia. Results. Compared with the normal group, AWR scores and body weight were clearly increased in the model group rats (both P < 0.01 ). The body weights were significantly elevated ( P < 0.01 , P < 0.05 ), but the AWR scores were reduced ( P < 0.05 , P < 0.01 ), after electroacupuncture and mild moxibustion treatment. Compared with levels in normal rats, BDNF and TrkB protein and mRNA expressions were significantly elevated in the IBS model rats ( P < 0.01 ) but were downregulated after mild moxibustion, electroacupuncture, and Western medicine treatment ( P < 0.01 ). Conclusion. Electroacupuncture and moxibustion improved visceral hypersensitivity of IBS rats possibly by reducing BDNF and TrkB protein and mRNA expressions in the colon and dorsal root ganglia.

Nicotinic receptor mediated stimulation of NO-generation in neurons of rat thoracic dorsal root ganglia

2004 ◽  
Vol 361 (1-3) ◽  
pp. 32-35 ◽  
Author(s):  
S. Papadopolou ◽  
P. Hartmann ◽  
K.S. Lips ◽  
W. Kummer ◽  
R.V. Haberberger
Keyword(s):  
Dorsal Root Ganglia ◽  
Nicotinic Receptor ◽  
Dorsal Root ◽  
Stimulation Of

Stimulation of Dorsal Root Ganglia and Degradation of Rabbit Annulus Fibrosus

Spine ◽  
1990 ◽  
Vol 15 (12) ◽  
pp. 1252-1256 ◽  
Author(s):  
A. PEDRINI-MILLE ◽  
J. N. WEINSTEIN ◽  
E. M. FOUND ◽  
C. B. CHUNG ◽  
V. K. GOEL
Keyword(s):  
Dorsal Root Ganglia ◽  
Annulus Fibrosus ◽  
Dorsal Root ◽  
Stimulation Of
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