BRAF Mutation Testing of Thyroid Fine-Needle Aspiration Specimens Enhances the Predictability of Malignancy in Thyroid Follicular Lesions of Undetermined Significance

2011 ◽  
Vol 55 (6) ◽  
pp. 570-575 ◽  
Author(s):  
Adebowale J. Adeniran ◽  
Pei Hui ◽  
David C. Chhieng ◽  
Manju L. Prasad ◽  
Kevin Schofield ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Mutation Testing ◽  
Fine Needle ◽  
Follicular Lesions ◽  
Thyroid Fine Needle Aspiration ◽  
Undetermined Significance

Diagnosing atypia of undetermined significance in thyroid fine needle aspiration samples using nuclear scoring

2019 ◽  
Vol 41 ◽  
pp. 112-115
Author(s):  
Aysegul Aksoy Altinboga ◽  
Canan Altunkaya ◽  
Hilal Ahsen ◽  
Berrak Gumuskaya ◽  
Oya Topaloglu ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Thyroid Fine Needle Aspiration ◽  
Undetermined Significance

Thyroid fine-needle aspiration with atypia of undetermined significance

2009 ◽  
Vol 117 (5) ◽  
pp. 298-304 ◽  
Author(s):  
Yan Shi ◽  
Xin Ding ◽  
Melissa Klein ◽  
Chiara Sugrue ◽  
Sandra Matano ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Thyroid Fine Needle Aspiration ◽  
Undetermined Significance

The Role of Telecytology in the Primary Diagnosis of Thyroid Fine-Needle Aspiration Specimens

2019 ◽  
Vol 64 (4) ◽  
pp. 323-331 ◽  
Author(s):  
Sule Canberk ◽  
Kemal Behzatoglu ◽  
Can K. Caliskan ◽  
Serkan Gelmez ◽  
Kerem C. Kayhan ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Digital Pathology ◽  
Daily Practice ◽  
Needle Aspiration ◽  
Primary Diagnosis ◽  
Daily Routine ◽  
Fine Needle ◽  
Advantages And Disadvantages ◽  
Thyroid Fine Needle Aspiration ◽  
Undetermined Significance

Introduction: The Acibadem Health Group (AHG) has been using telepathology/digital pathology stations since 2006. In 2013, the system was changed from videoconferencing to digital pathology (whole-slide imaging) utilizing 3DHISTECH scanners and software. In 2017, digital cytology started to be used for routine cytopathologic diagnosis for thyroid fine-needle aspiration (FNA) cases. Material and Methods: Two hundred and twenty-seven thyroid cases were received for analysis using telecytology (TC) during the period from November 2017 to May 2018. Rapid on-site evaluation was performed at the Atakent Hospital of the AHG by a cytotechnologist and scanned on the same day. For every case, there were Diff-Quik- and Papanicolaou-stained FNA smears. Each glass slide was digitized with a 3DHISTECH whole-slide scanner in 1 focal Z-plane at ×40 magnification. Results: Two hundred and twenty-seven thyroid FNA specimens were retrieved, of which 25 had histologic follow-up. Samples were classified as nondiagnostic in 3%, benign in 74%, atypia of undetermined significance/follicular lesion of undetermined significance in 13%, suspicious for follicular neoplasia/follicular neoplasia in 3%, suspicious for malignancy in 4%, and malignant in 3%. When only the “suspicious for malignancy” and “malignancy” categories were considered positive tests, cytology sensitivity and specificity using TC for diagnosis was 100%. Conclusions: Our data demonstrate that TC is suitable to provide a primary diagnosis in daily routine cytology practice. Despite the promising results, there were some challenges stemming from the novelty of using TC for the primary diagnosis. The study also addresses both advantages and disadvantages of TC in daily practice to increase the efficiency of the technique in primary diagnosis.

scholarly journals Malignancy Risk and Related Factors of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance in Thyroid Fine Needle Aspiration

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
So-hyeon Hong ◽  
Hyejin Lee ◽  
Min-Sun Cho ◽  
Jee Eun Lee ◽  
Yeon-Ah Sung ◽  
...  
Keyword(s):  
Clinical Features ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Related Factors ◽  
Fine Needle ◽  
Malignancy Risk ◽  
Thyroid Fine Needle Aspiration ◽  
Risk Of Malignancy ◽  
Undetermined Significance

Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in thyroid fine needle aspiration (FNA) is a challenging category. The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. Therefore, we analyzed the malignancy risk of AUS/FLUS according to radiological and clinical features. A total of 687 nodules that had been initially diagnosed as AUS/FLUS were retrospectively reviewed from 6365 thyroid FNAs between 2011 and 2014. The ultrasonographic (US) features were categorized using the Korean Thyroid Imaging Reporting and Data System. Radiological and clinical features were compared according to the second FNA results or histologically confirmed results from surgery. Repeat FNA was performed on 248 (36%) nodules, and 49 (7%) nodules underwent immediate surgery. Among the 248 nodules subjected to repeated FNA, 49 (20%) nodules were diagnosed again as AUS/FLUS, 123 (50%) were found to be benign, and 47 (19%) were diagnosed as follicular neoplasm, suspicious for malignancy or malignant. Among histologically confirmed nodules, the US features were more unfavorable in malignant nodules, and hypo- or anechogenicity was associated with a higher risk of malignancy after adjusting for age, size, and other US features (P<0.01). In conclusion, we observed that malignant nodules tended to show unfavorable US features, especially hypo- or anechogenicity. Age, sex, and thyroid function were not significantly associated with malignancy risk. We also found out that malignancy risk was not different between the group which underwent immediate operation following the AUS/FLUS diagnosis and the group which underwent repeated FNA after the initial diagnosis.

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