Fine Needle Aspiration Diagnosis of Malignant Mixed Tumor (Carcinosarcoma) Arising in Pleomorphic Adenoma of the Salivary Gland

1998 ◽  
Vol 42 (4) ◽  
pp. 1027-1031 ◽  
Author(s):  
Taeyub Kim ◽  
Ghil Suk Yoon ◽  
Onja Kim ◽  
Gyungyub Gong
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Mixed Tumor ◽  
Fine Needle ◽  
Malignant Mixed Tumor

Glial Fibrillary Acidic Protein and CD57 Immunolocalization in Cell Block Preparations Is a Useful Adjunct in the Diagnosis of Pleomorphic Adenoma

2007 ◽  
Vol 131 (9) ◽  
pp. 1373-1377 ◽  
Author(s):  
Sejal S. Shah ◽  
Vishal S. Chandan ◽  
David C. Wilbur ◽  
Kamal K. Khurana
Keyword(s):  
Salivary Gland ◽  
Glial Fibrillary Acidic Protein ◽  
Pleomorphic Adenoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Acidic Protein ◽  
Cell Block ◽  
Cytologic Diagnosis ◽  
Fine Needle

Abstract Context.—The cytologic distinction between pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) can be diagnostically challenging in aspirate smears. Hence a cytologic diagnosis of “atypical cytology” with a differential diagnosis including PA and ACC is occasionally rendered in a subset of salivary gland fine-needle aspirations. Objective.—To evaluate the role of glial fibrillary acidic protein (GFAP) and CD57 expression in cell block material obtained during fine-needle aspiration procedure in differentiating PA from ACC. Design.—We performed GFAP and CD57 immunostains on formalin-fixed, paraffin-embedded cell block sections of 26 salivary gland fine-needle aspiration cases with the following cytologic diagnoses: (1) PA (10 cases); (2) atypical cytology, cannot exclude ACC (8 cases); and (3) ACC (8 cases). Results.—All 10 (100%) cases with cytologic diagnoses of PA were positive for GFAP, and 8 (80%) of 10 cases were positive for CD57; tissue follow-up confirmed the diagnosis of PA in all cases. All 8 (100%) cases with cytologic diagnosis of ACC were negative for both GFAP and CD57; tissue follow-up confirmed the diagnoses of ACC in all cases. Of the 8 cases with diagnoses of atypical cytology, 4 (50%) were negative and 4 (50%) were positive for both GFAP and CD57. Subsequent tissue follow-up in these cases revealed 4 cases of ACC (all negative for GFAP and CD57) and 4 cases of PA (all positive for GFAP and CD57). Conclusions.—Our results show that positive staining for GFAP and CD57 serves as a useful adjunct for the diagnosis of PA and helps to reduce the uncertainty in challenging cases.

Submandibular salivary gland tumors: a clinicopathologic review of 58 cases

2018 ◽  
Vol 7 (1) ◽  
pp. 54-58
Author(s):  
Marcin Jarosław Kubiak ◽  
Dariusz Kaczmarczyk ◽  
Aleksandra Oleśna ◽  
Alina Morawiec-Sztandera
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Pleomorphic Adenoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Objectives: Salivary gland tumors account for only 3% of head and neck tumors. Their character is mostly benign, although tumors of the submandibular gland are more often malignant. The purpose of this article was to evaluate the structure of patients operated due to submandibular gland tumor and to study the correlation between fine-needle aspiration cytology and postoperative histopathological examination. Methodology: We retrospectively analyzed the medical records of all patients with submandibular gland tumors. The collected data included the demographic structure, results of preoperative fine-needle aspiration cytology and postoperative histopathologic examination. Results: We analyzed 58 patients – 35 women and 23 men with a mean age of 56.6 years. The character of the lesion was benign in 45 cases and malignant in 13. The most frequent benign tumors were pleomorphic adenoma, inflammatory tumor and Warthin’s tumor, whereas most common malignancies were carcinoma planoepitheliale and lymphoma . There were four recurrences. Moreover, we compared results of preoperative fine-needle aspiration cytology and histopathological findings. The accuracy of this examination was almost 83%; 56% of incorrect results involved nondetection of malignancies. The sensitivity and specificity in the diagnosis of those tumors were 58.3% and 97.5%, respectively. Conclusions: The most common types of submandibular gland are pleomorphic adenoma and carcinoma planoepitheliale and lymphoma amongst malignancies. Fine-needle aspiration cytology is accurate in the preoperative diagnosis, mistakes are mostly caused by underdiagnosis of malignant tumors.

scholarly journals Fine needle aspiration cytology diagnosed Pleomorphic adenoma of Soft Palate- A rare case report

2020 ◽  
Vol 4 (12) ◽  
pp. 01-02
Author(s):  
Anju Khairwa
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Soft Palate ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Rare Case ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Pleomorphic adenoma (PA) is benign tumor of salivary gland. Pleomorphic adenoma contains both epithelial and myoepithelial elements and it arises from myoepithelial cells of salivary gland. The index study to describe rare case of pleomorphic adenoma of soft palate diagnosed by FNAC (fine needle aspiration cytology).

scholarly journals Fine Needle Aspiration of an Unusual Malignant Mixed Tumor in the Parotid Gland

2014 ◽  
Vol 45 (2) ◽  
pp. 141-146
Author(s):  
Xiu Yang ◽  
Adam Cole ◽  
Maja Oktay ◽  
Richard Smith ◽  
Antonio Cajigas ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Mixed Tumor ◽  
Fine Needle ◽  
Malignant Mixed Tumor

scholarly journals Evaluation of Fine Needle Aspiration Cytology in Diagnosis of Salivary Gland Lesions: A Teaching Hospital Based Study

2020 ◽  
Vol 9 (1) ◽  
pp. PT06-PT08
Author(s):  
Santanu Kumar ◽  
Wakil Ahmad
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Reliable Technique ◽  
Fine Needle ◽  
Careful Clinical Examination ◽  
Needle Aspiration Cytology

Background: FNAC is a cytodiagnostic method based on the morphological findings of individual cells, group of cells, and microparticles of tissue, acquired using a needle. The role of FNAC for the diagnosis of salivary gland masses is well documented. The traditional open biopsy is no longer justified because of the risk of tumor spillage and damage to the facial nerve.Subjects and Methods:FNAC procedure was explained to the patient and patient was placed in a comfortable position. They were then subjected to fine needle aspiration cytology. Aspirations were carried out with 21 or 22 gauge needles of varying lengths with 10 ml syringes in a syringe holder after careful clinical examination of the lesion.Results:Chronic sialadenitis was the most common non-neoplastic lesion (13.2%) followed by cystic lesions (5.3%), acute on chronic sialadenitis (3.9%) and chronic granulomatous inflammation (2.6%). Pleomorphic adenoma (57.9%) was the most common benign neoplasm. Warthin’stumour accounted for (6.6%). Mucoepidermoid carcinoma was the most common malignant lesion (5.3%) followed by acinic cell carcinoma (1.3%), carcinoma-ex pleomorphic adenoma (1.3%) and adenoid cystic carcinoma (2.6%).Conclusion: Fine needle aspiration cytology of the salivary gland is a safe and reliable technique in the primary diagnosis of salivary gland lesions. Although, limitations are encountered while predicting specific lesions on cytology, especially when dealing with cystic and some malignant lesions.

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