scholarly journals Stem Cell-Derived Vascular Endothelial Cells and Their Potential Application in Regenerative Medicine

2012 ◽  
Vol 195 (1-2) ◽  
pp. 41-47 ◽  
Author(s):  
Hera Chaudhury ◽  
Eric Raborn ◽  
Lauren C. Goldie ◽  
Karen K. Hirschi
Keyword(s):  
Endothelial Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Potential Application ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals TMIC-39. CROSSTALK WITH VASCULAR ENDOTHELIAL CELLS DRIVES PRONEURAL GLIOMA STEM CELL PROLIFERATION THROUGH THE UPREGULATED NTF3/TrkB PATHWAY

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi251-vi251
Author(s):  
Suojun Zhang ◽  
Hai Yu ◽  
Soniya Bastola ◽  
Mutsuko Minata ◽  
Heba Allah Alsheikh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Stem Cell ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Glioma Stem Cell ◽  
Stem Cell Proliferation

scholarly journals Hair follicle germs containing vascular endothelial cells for hair regenerative medicine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatsuto Kageyama ◽  
Yang-Sook Chun ◽  
Junji Fukuda
Keyword(s):  
Endothelial Cells ◽  
Regenerative Medicine ◽  
Hair Follicle ◽  
Vascular Endothelial Cells ◽  
Morphological Characteristics ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Vascular Endothelial ◽  
Dermal Papilla Cells

AbstractHair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an approach for fabricating HFGs containing vascular endothelial cells. Epithelial, dermal papilla, and vascular endothelial cells initially formed a single aggregate, which subsequently became a dumbbell-shaped HFG, wherein the vascular endothelial cells localized in the region of dermal papilla cells. The HFGs containing vascular endothelial cells exhibited higher expression of hair morphogenesis-related genes in vitro, along with higher levels of hair shaft regeneration upon transplantation to the dorsal side of nude mice, than those without vascular endothelial cells. The generated hair follicles represented functional characteristics, such as piloerection, as well as morphological characteristics comparable to those of natural hair shafts. This approach may provide a promising strategy for fabricating tissue grafts with higher hair inductivity for hair regenerative medicine.

Sign in / Sign up

Export Citation Format

Share Document