Association of Clusterin Gene Polymorphisms with Late-Onset Alzheimer’s Disease

2011 ◽  
Vol 32 (3) ◽  
pp. 198-201 ◽  
Author(s):  
Huiying Gu ◽  
Xing Wei ◽  
Shirley Chen ◽  
Alexander Kurz ◽  
Ulrich Müller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Late Onset

scholarly journals Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer’s Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0125186 ◽  
Author(s):  
Zhuling Yu ◽  
Wei Li ◽  
Deren Hou ◽  
Lin Zhou ◽  
Yanyao Deng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Late Onset ◽  
Adiponectin Gene

scholarly journals Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer’s disease

Bioimpacts ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 219-225 ◽  
Author(s):  
Elham Mehdizadeh ◽  
Mohammad Khalaj-Kondori ◽  
Zeinab Shaghaghi-Tarakdari ◽  
Saeed Sadigh-Eteghad ◽  
Mahnaz Talebi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Neurodegenerative Disorder ◽  
Late Onset ◽  
Salting Out ◽  
Age And Gender ◽  
Blood Samples ◽  
Significant Difference ◽  
And Gender

Introduction: Alzheimer’s disease (AD), which is a progressive neurodegenerative disorder, causes structural and functional brain disruption. MS4A6A, TREM2, and CD33 gene polymorphisms loci have been found to be associated with the pathobiology of late-onset AD (LOAD). In the present study, we tested the hypothesis of association of LOAD with rs983392, rs75932628, and rs3865444 polymorphisms in MS4A6A, TREM2, CD33 genes, respectively.Methods: In the present study, 113 LOAD patients and 100 healthy unrelated age- and gender-matched controls were selected. DNA was extracted from blood samples by the salting-out method and the genotyping was performed by RFLP-PCR. Electrophoresis was carried out on agarose gel. Sequencing was thereafter utilized for the confirmation of the results. Results: Only CD33 rs3865444 polymorphism revealed a significant difference in the genotypic frequencies of GG (P = 0.001) and GT (P = 0.001), and allelic frequencies of G (P = 0.033) and T (P = 0.03) between LOAD patients and controls. Conclusion: The evidence from the present study suggests that T allele of CD33 rs3865444 polymorphism is associated with LOAD in the studied Iranian population.

scholarly journals Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population

2017 ◽  
Vol 14 (1) ◽  
pp. 81 ◽  
Author(s):  
Young Jong Kim ◽  
Jin Kyung Park ◽  
Won Sub Kang ◽  
Su Kang Kim ◽  
Changsu Han ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Late Onset ◽  
Korean Population ◽  
Mitofusin 2

P3-083: Effects of Apoe Gene Polymorphisms on Late Onset Alzheimer’s Disease in a Korean Population

2016 ◽  
Vol 12 ◽  
pp. P850-P850
Author(s):  
Kyu Yeong Choi ◽  
Tamil Iniyan Gunasekaran ◽  
Ji Su Lee ◽  
Jang Jae Lee ◽  
Na Hyeon Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Late Onset ◽  
Apoe Gene ◽  
Korean Population

scholarly journals Association between Interleukin 16 Gene Polymorphisms (rs1131445, rs4072111) and Late Onset of Alzheimer’s Disease in Iranian Patients

Salmand ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 64-71
Author(s):  
Nazanin Esmaeili Anvar ◽  
Niloofar Bazazzadegan ◽  
Mina Ohadi ◽  
Kourosh Kamali ◽  
Hamidreza Khorram Khorshid
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Late Onset ◽  
Iranian Patients

Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease

2008 ◽  
Vol 441 (2) ◽  
pp. 233-236 ◽  
Author(s):  
Seppo Helisalmi ◽  
Timo Tarvainen ◽  
Saila Vepsäläinen ◽  
Anne Mari Koivisto ◽  
Mikko Hiltunen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Gene Polymorphisms ◽  
Late Onset ◽  
Pparg Gene

Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: A genetic association study

2009 ◽  
Vol 465 (3) ◽  
pp. 272-275 ◽  
Author(s):  
Kyungsook Ahn ◽  
Ju Hee Song ◽  
Doh Kwan Kim ◽  
Moon Ho Park ◽  
Sangmee A. Jo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genetic Association ◽  
Gene Polymorphisms ◽  
Genetic Association Study ◽  
Late Onset ◽  
Korean Population
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