Primary Squamous Cell Carcinoma of the Thyroid Diagnosed by Fine Needle Aspiration Cytology

1999 ◽  
Vol 43 (4) ◽  
pp. 659-662 ◽  
Author(s):  
Perikala V. Kumar ◽  
Seyed Ali Malekhusseini ◽  
Abdol Rasool Talei
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Primary Squamous Cell Carcinoma ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Squamous Cell Carcinoma in the Third Eyelid of a Dog

2021 ◽  
Vol 49 ◽  
Author(s):  
Beatriz Crepaldi Aléssio ◽  
Juliana Paniago Lordello de Paula ◽  
Gustavo Gomes de Oliveira ◽  
Silvana Marques Caramalac ◽  
Alda Izabel de Souza ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
The Third ◽  
Needle Aspiration Cytology

Background: Squamous cell carcinoma is a malignant neoplasm that originates from the keratinized stratified squamous epithelium and predominantly affect light-skinned animals. In dogs, breeds such as American Staffordshire Terriers, white or speckled Bull Terriers, and Beagles have a higher predisposition. Squamous cell carcinoma presents in the skin, at slightly pigmented or hairy sites, especially in digits, but also may occur in the nasal planum, oral mucosa, and rarely, in the eye. Considering that few reports have been published on eye neoplasms, the aim of this paper is to describe a dog with a lesion in the third eyelid of his right eye which was diagnosticated with squamous cell carcinoma. Case: A 10-year-old male American Staffordshire dog was admitted to the Veterinary Medical Teaching Hospital of the Veterinary Medicine and Zootechnics College, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Brazil with injury to the right eye. During the physical examination, there was also a non-adhered lump near the foreskin, measuring 1.5 cm in diameter. In addition, there was another lump in the third eyelid of the right eye, approximately 3 mm in diameter. Cytology of the dermal nodule was performed by fine-needle aspiration cytology; however, the sample was insufficient for cytological evaluation. Therefore, the animal was placed under general anesthesia for skin lump excision and for fine-needle aspiration cytology of the third eyelid nodule. The histopathological exam revealed high cellularity of epithelial cells, intense anisocytosis and pleomorphism, cytoplasmic basophilia and vacuolation, multiple evident nucleoli, and anisocariosis and coarse chromatin. These finds were compatible with squamous cell carcinoma, which was the same result suggested by fine-needle aspiration cytology of the third eyelid sample. Based on these results, the dog underwent a surgical procedure for enucleation and subsequent histopathological evaluation of the nodule in the third eyelid, which confirmed the squamous cell carcinoma diagnosis.Discussion: Squamous cell carcinoma is an extremely aggressive tumor with low metastatic potential, characterized by invasion of the dermis by proliferation of malignant epithelial cells from the prickly layer. It is most common in elderly animals, and American Staffordshires are among the breeds that are predisposed to develop this tumor. The clinical presentation is highly variable, depending on the tissue involved. In this case, the dermal nodule was an elevated area on the skin and the third eyelid nodule resembled an ulcerative mass. Cytological examination from the lesion located on the third eyelid, showed malignancies cytoplasmic changes frequently found in carcinomas such as anisocytosis, cytoplasmic basophilia, and cell pleomorphism. In addition, nuclear changes had also occurred, such as crass chromatin, multiple evident nucleoli, and multinucleated cells. A presumptive diagnosis was made based on cytology and was confirmed after biopsy and histopathological examination. Because it is uncommon in dogs, squamous cell carcinoma of the third eyelid may be misdiagnosed, delaying correct treatment, and accelerating the development of the tumor. Currently, various therapeutic approaches are available, such as surgical excision, electrosurgery, cryosurgery, radiation, and hyperthermia. The choice of treatment depends on the location and stage of the lesions. Surgical treatment should be aimed at removing sufficient tissue to leave surgical margins free of neoplastic cells.

p16INKa Immunocytochemistry in Fine-Needle Aspiration Cytology Smears of Metastatic Head and Neck Squamous Cell Carcinoma

2013 ◽  
Vol 57 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Reni Grimes ◽  
Monica T. Garcia-Buitrago ◽  
Merce Jorda ◽  
Parvin Ganjei-Azar ◽  
Annapoorna Ferrell ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Diagnostic Reliability of Fine Needle Aspiration Cytology against Histopathology for the Diagnosis of Oral Squamous Cell Carcinoma and Oral Leukoplakia

2012 ◽  
Vol 13 (4) ◽  
pp. 545-549 ◽  
Author(s):  
Santosh T Olekar ◽  
T Sangeeta ◽  
YS Prasanna Kumar ◽  
M Gururaj
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

ABSTRACT Aim The purpose of this study was to determine the possibility of using fine needle aspiration cytology (FNAC) as a primary diagnostic test in oral leukoplakia and squamous cell carcinoma. Materials and methods This study consisted of clinically diagnosed 15 cases of leukoplakia and 15 cases of oral squamous cell carcinomas. FNAC and biopsy were done on all the cases. A cytological and histopathological correlation was undertaken to determine the proportion of cancers. A 23-gauge sterile disposable needle was attached to a disposable syringe and introduced into the lesion at the proposed biopsy site in one movement. In leukoplakias, the center of the lesion or erythroplakic areas and, in squamous cell carcinomas, proliferative areas and edges of the ulcers were chosen. Results In leukoplakia group, out of 15 biopsy samples, one (6.67%) sample was negative and 14 (93.33%) were positive. Whereas out of 15 FNAC samples, 14 (93.33%) were negative and one (6.67%) sample was positive. In squamous cell carcinoma, out of 15 biopsy samples, no sample was negative and all (100.00%) were positive. Whereas out of 15 FNAC samples, two (13.33%) were negative and 13 (86.67%) sample were positive. Conclusion It is noted that FNAC can be employed as a sound diagnostic tool for rapid diagnosis of oral squamous cell carcinoma. It may be particularly useful in cases, where formal biopsy procedure is difficult or contraindicated due to medical reasons or in cases of advanced malignancy. Clinical significance FNAC has been shown to be reliable and safe technique in the diagnosis of malignant in the head and neck. When the aspirations are performed by cytopathologists, it is easy to perform a rapid staining of the first smear and within 10 to 15 minutes to ensure that the material is sufficient and diagnosable and to suggest a preliminary diagnosis. How to cite this article Olekar ST, Sangeeta T, Kumar YSP, Gururaj M. Diagnostic Reliability of Fine Needle Aspiration Cytology against Histopathology for the Diagnosis of Oral Squamous Cell Carcinoma and Oral Leukoplakia. J Contemp Dent Pract 2012;13(4):545-549.

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